VEGFC
Summary: The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family. The encoded protein promotes angiogenesis and endothelial cell growth, and can also affect the permeability of blood vessels. The proprotein is further cleaved into a fully processed form that can bind and activate VEGFR-2 and VEGFR-3 receptors. [provided by RefSeq, Apr 2014].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| vascular endothelial growth factor C | MIM:601528 | Ensembl:ENSG00000150630 | HGNC:HGNC:12682 | PA37304 | 4q34.3 |
GO terms in VEGFC
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0008083 | growth factor activity |
| MF | IBA | GO:0042056 | chemoattractant activity |
| MF | IDA | GO:0042056 | chemoattractant activity |
| MF | IBA | GO:0043185 | vascular endothelial growth factor receptor 3 binding |
| MF | IPI | GO:0043185 | vascular endothelial growth factor receptor 3 binding |
| CC | TAS | GO:0005576 | extracellular region |
| CC | IBA | GO:0005615 | extracellular space |
| CC | IEA | GO:0016020 | membrane |
| CC | TAS | GO:0031093 | platelet alpha granule lumen |
| BP | IBA | GO:0001525 | angiogenesis |
| BP | IBA | GO:0001666 | response to hypoxia |
| BP | IBA | GO:0001934 | positive regulation of protein phosphorylation |
| BP | IBA | GO:0001938 | positive regulation of endothelial cell proliferation |
| BP | IEA | GO:0001954 | positive regulation of cell-matrix adhesion |
| BP | IBA | GO:0002040 | sprouting angiogenesis |
| BP | IEA | GO:0002052 | positive regulation of neuroblast proliferation |
| BP | TAS | GO:0002576 | platelet degranulation |
| BP | TAS | GO:0006929 | substrate-dependent cell migration |
| BP | TAS | GO:0007165 | signal transduction |
| BP | TAS | GO:0008284 | positive regulation of cell proliferation |
| BP | IEA | GO:0008285 | negative regulation of cell proliferation |
| BP | IEA | GO:0009887 | animal organ morphogenesis |
| BP | IEA | GO:0010469 | regulation of signaling receptor activity |
| BP | IEA | GO:0016331 | morphogenesis of embryonic epithelium |
| BP | IEA | GO:0030947 | regulation of vascular endothelial growth factor receptor signaling pathway |
| BP | IEA | GO:0031954 | positive regulation of protein autophosphorylation |
| BP | IBA | GO:0038084 | vascular endothelial growth factor signaling pathway |
| BP | IEA | GO:0042493 | response to drug |
| BP | IEA | GO:0043536 | positive regulation of blood vessel endothelial cell migration |
| BP | IBA | GO:0045766 | positive regulation of angiogenesis |
| BP | IEA | GO:0045776 | negative regulation of blood pressure |
| BP | IBA | GO:0048010 | vascular endothelial growth factor receptor signaling pathway |
| BP | IDA | GO:0048010 | vascular endothelial growth factor receptor signaling pathway |
| BP | TAS | GO:0048010 | vascular endothelial growth factor receptor signaling pathway |
| BP | IEA | GO:0050714 | positive regulation of protein secretion |
| BP | IEA | GO:0050731 | positive regulation of peptidyl-tyrosine phosphorylation |
| BP | IEA | GO:0050918 | positive chemotaxis |
| BP | IBA | GO:0050930 | induction of positive chemotaxis |
| BP | IDA | GO:0050930 | induction of positive chemotaxis |
| BP | IEA | GO:0051781 | positive regulation of cell division |
| BP | IBA | GO:0060754 | positive regulation of mast cell chemotaxis |
| BP | IDA | GO:0060754 | positive regulation of mast cell chemotaxis |
| BP | IEA | GO:1901492 | positive regulation of lymphangiogenesis |
| BP | IEA | GO:1990830 | cellular response to leukemia inhibitory factor |
Gene expression in normal tissue: VEGFC
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in VEGFC
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP1591 | Heart Development |
| wikipathways | WP306 | Focal Adhesion |
| wikipathways | WP3593 | miR-148a-miR-31-FIH1-HIF1?-Notch signaling in glioblastoma |
| wikipathways | WP3932 | Focal Adhesion-PI3K-Akt-mTOR-signaling pathway |
| wikipathways | WP4172 | PI3K-Akt Signaling Pathway |
| pid | integrin_a9b1_pathway | Alpha9 beta1 integrin signaling events |
| pid | lymphangiogenesis_pathway | VEGFR3 signaling in lymphatic endothelium |
| pid | vegf_vegfr_pathway | VEGF and VEGFR signaling network |
| kegg | hsa04010 | MAPK signaling pathway - Homo sapiens (human) |
| kegg | hsa04014 | Ras signaling pathway - Homo sapiens (human) |
| kegg | hsa04015 | Rap1 signaling pathway - Homo sapiens (human) |
| kegg | hsa04060 | Cytokine-cytokine receptor interaction - Homo sapiens (human) |
| kegg | hsa04151 | PI3K-Akt signaling pathway - Homo sapiens (human) |
| kegg | hsa04510 | Focal adhesion - Homo sapiens (human) |
| kegg | hsa04668 | TNF signaling pathway - Homo sapiens (human) |
| kegg | hsa04926 | Relaxin signaling pathway - Homo sapiens (human) |
| kegg | hsa04933 | AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human) |
| kegg | hsa05200 | Pathways in cancer - Homo sapiens (human) |
| pharmgkb | PA2032 | VEGF Signaling Pathway |
| reactome | R-HSA-109582 | Hemostasis |
| reactome | R-HSA-114608 | Platelet degranulation |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-194138 | Signaling by VEGF |
| reactome | R-HSA-194313 | VEGF ligand-receptor interactions |
| reactome | R-HSA-195399 | VEGF binds to VEGFR leading to receptor dimerization |
| reactome | R-HSA-76002 | Platelet activation, signaling and aggregation |
| reactome | R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ |
| reactome | R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD61 | Kinetin riboside | 1 |
| iGMDRD57 | Chloropentafluorobenzene | 3 |
| iGMDRD280 | CYTOCHALASIN B | 3 |
| iGMDRD297 | Austocystin D | 3 |
| iGMDRD359 | OSW-1 | 3 |
| iGMDRD1008 | SR-II-138A | 3 |
| iGMDRD387 | CHIR-99021 | 1 |
| iGMDRD546 | BMS-754807 | 3 |
| iGMDRD523 | Cyanoquinoline, 11 | 3 |
| iGMDRD872 | BRD7137 | 6 |
| iGMDRD399 | Selumetinib | 3 |
| iGMDRD100 | Zebularine | 4 |
| iGMDRD60 | Quinoclamine | 6 |
| iGMDRD524 | ISX-9 | 6 |
| iGMDRD451 | Serdemetan | 3 |
| iGMDRD158 | NSC141540 | 3 |
| iGMDRD255 | SB225002 | 3 |
| iGMDRD434 | BMS-536924 | 1 |
| iGMDRD171 | Pemetrexed | 3 |
| iGMDRD187 | BRD9876 | 3 |
| iGMDRD870 | BRD63610 | 3 |
| iGMDRD481 | Dactolisib | 3 |
| iGMDRD885 | Compound 110 | 6 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in VEGFC
CLASSFICATION
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