VEGFC

Summary: The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family. The encoded protein promotes angiogenesis and endothelial cell growth, and can also affect the permeability of blood vessels. The proprotein is further cleaved into a fully processed form that can bind and activate VEGFR-2 and VEGFR-3 receptors. [provided by RefSeq, Apr 2014].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Namevascular endothelial growth factor C
OMIM IDMIM:601528
Ensembl IDEnsembl:ENSG00000150630
HGNC IDHGNC:HGNC:12682
PHARMGKB IDPA37304
Map Location4q34.3

GO terms in VEGFC


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IPI GO:0005515 protein binding
MF IBA GO:0008083 growth factor activity
MF IBA GO:0042056 chemoattractant activity
MF IDA GO:0042056 chemoattractant activity
MF IBA GO:0043185 vascular endothelial growth factor receptor 3 binding
MF IPI GO:0043185 vascular endothelial growth factor receptor 3 binding
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Gene expression in normal tissue: VEGFC

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

undefined16One carbon pool by folate1PI3K/MTOR signaling1DNA replication1ERK MAPK signaling1WNT signaling1IGFR signaling1p53 pathway1

Pathways in VEGFC


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Database
Pathway ID
Pathway Des.
wikipathways WP1591 Heart Development
wikipathways WP306 Focal Adhesion
wikipathways WP3593 miR-148a-miR-31-FIH1-HIF1?-Notch signaling in glioblastoma
wikipathways WP3932 Focal Adhesion-PI3K-Akt-mTOR-signaling pathway
wikipathways WP4172 PI3K-Akt Signaling Pathway
pid integrin_a9b1_pathway Alpha9 beta1 integrin signaling events
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD61 Kinetin riboside 1
iGMDRD57 Chloropentafluorobenzene 3
iGMDRD280 CYTOCHALASIN B 3
iGMDRD297 Austocystin D 3
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in VEGFC

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
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