ANKK1
Summary: The protein encoded by this gene belongs to the Ser/Thr protein kinase family, and protein kinase superfamily involved in signal transduction pathways. This gene is closely linked to DRD2 gene (GeneID:1813) on chr 11, and a well studied restriction fragment length polymorphism (RFLP) designated TaqIA, was originally associated with the DRD2 gene, however, later was determined to be located in exon 8 of ANKK1 gene (PMIDs: 18621654, 15146457), where it causes a nonconservative amino acid substitution. It is not clear if this gene plays any role in neuropsychiatric disorders previously associated with Taq1A RFLP. [provided by RefSeq, Sep 2009].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| ankyrin repeat and kinase domain containing 1 | MIM:608774 | Ensembl:ENSG00000170209 | HGNC:HGNC:21027 | PA134872551 | 11q23.2 |
GO terms in ANKK1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IEA | GO:0006468 | protein phosphorylation |
| MF | IEA | GO:0004674 | protein serine/threonine kinase activity |
| MF | IEA | GO:0005524 | ATP binding |
Gene expression in normal tissue: ANKK1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ANKK1
| Database | Pathway ID | Pathway Des. |
|---|
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD158 | NSC141540 | 1 |
| iGMDRD705 | Nakiterpiosin | 3 |
| iGMDRD289 | Parthenolide | 2 |
| iGMDRD6 | AM-580 | 3 |
| iGMDRD52 | Rotenone | 5 |
| iGMDRD872 | BRD7137 | 3 |
| iGMDRD188 | Piperlongumine | 3 |
| iGMDRD286 | Nsc 632839 | 3 |
| iGMDRD67 | PENFLURIDOL | 3 |
| iGMDRD398 | Sepantronium | 2 |
| iGMDRD780 | PP-30 | 2 |
| iGMDRD662 | JQ-1 | 2 |
| iGMDRD147 | Prima-1 | 3 |
| iGMDRD886 | Compound 1541A | 2 |
| iGMDRD322 | FK 866 | 2 |
| iGMDRD268 | Cerulenin | 2 |
| iGMDRD23 | Gossypol | 3 |
| iGMDRD330 | BRD4132 | 3 |
| iGMDRD599 | Salermide | 3 |
| iGMDRD144 | NSC95397 | 3 |
| iGMDRD424 | Tamatinib | 3 |
| iGMDRD781 | Sirolimus | 1 |
| iGMDRD494 | Neopeltolide | 3 |
| iGMDRD523 | Cyanoquinoline, 11 | 3 |
| iGMDRD85 | Ursolic acid | 1 |
| iGMDRD61 | Kinetin riboside | 1 |
| iGMDRD679 | Bistramide A | 2 |
| iGMDRD280 | CYTOCHALASIN B | 2 |
| iGMDRD466 | Chaetocin | 2 |
| iGMDRD394 | BX-795 | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ANKK1
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