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CDH2

Summary: This gene encodes a classical cadherin and member of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein is proteolytically processed to generate a calcium-dependent cell adhesion molecule and glycoprotein. This protein plays a role in the establishment of left-right asymmetry, development of the nervous system and the formation of cartilage and bone. [provided by RefSeq, Nov 2015].

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
cadherin 2	MIM:114020	Ensembl:ENSG00000170558	HGNC:HGNC:1759	PA26293	18q12.1

Gene Categories:

CELL SURFACE DRUGGABLE GENOME

GO terms in CDH2

Term Type	Evidence Type	GO Term ID	GO Des.
BP	IBA	GO:0000902	cell morphogenesis
BP	IBA	GO:0007043	cell-cell junction assembly
BP	TAS	GO:0007155	cell adhesion
BP	IBA	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules
BP	IEA	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules
BP	IEA	GO:0007157	heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
BP	IBA	GO:0007275	multicellular organism development
BP	IBA	GO:0007416	synapse assembly
BP	IBA	GO:0007420	brain development
BP	ISS	GO:0010001	glial cell differentiation
BP	IBA	GO:0016339	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules
BP	IEA	GO:0016339	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules
BP	IEA	GO:0016477	cell migration
BP	IEA	GO:0021987	cerebral cortex development
BP	IBA	GO:0034332	adherens junction organization
BP	TAS	GO:0034332	adherens junction organization
BP	IEA	GO:0043410	positive regulation of MAPK cascade
BP	TAS	GO:0043687	post-translational protein modification
BP	TAS	GO:0044267	cellular protein metabolic process
BP	IBA	GO:0044331	cell-cell adhesion mediated by cadherin
BP	ISS	GO:0044331	cell-cell adhesion mediated by cadherin
BP	IBA	GO:0048514	blood vessel morphogenesis
BP	IEA	GO:0048514	blood vessel morphogenesis
BP	IEA	GO:0048854	brain morphogenesis
BP	IEA	GO:0048872	homeostasis of number of cells
BP	IBA	GO:0050770	regulation of axonogenesis
BP	IEA	GO:0051146	striated muscle cell differentiation
BP	TAS	GO:0051149	positive regulation of muscle cell differentiation
BP	IBA	GO:0051966	regulation of synaptic transmission, glutamatergic
BP	IEA	GO:0060019	radial glial cell differentiation
BP	IEA	GO:0060563	neuroepithelial cell differentiation
BP	IEA	GO:0070445	regulation of oligodendrocyte progenitor proliferation
BP	IEA	GO:0072659	protein localization to plasma membrane
BP	IEA	GO:0090090	negative regulation of canonical Wnt signaling pathway
BP	IEA	GO:0097118	neuroligin clustering involved in postsynaptic membrane assembly
BP	ISS	GO:0097150	neuronal stem cell population maintenance
BP	IEA	GO:1902897	regulation of postsynaptic density protein 95 clustering
BP	IEA	GO:2000809	positive regulation of synaptic vesicle clustering
CC	IBA	GO:0005737	cytoplasm
CC	IDA	GO:0005737	cytoplasm
CC	TAS	GO:0005788	endoplasmic reticulum lumen
CC	IBA	GO:0005886	plasma membrane
CC	IDA	GO:0005886	plasma membrane
CC	TAS	GO:0005886	plasma membrane
CC	IDA	GO:0005911	cell-cell junction
CC	IBA	GO:0005913	cell-cell adherens junction
CC	IDA	GO:0005913	cell-cell adherens junction
CC	IEA	GO:0005916	fascia adherens
CC	HDA	GO:0005925	focal adhesion
CC	IBA	GO:0009986	cell surface
CC	ISS	GO:0009986	cell surface
CC	IBA	GO:0014069	postsynaptic density
CC	IEA	GO:0014069	postsynaptic density
CC	IBA	GO:0014704	intercalated disc
CC	ISS	GO:0014704	intercalated disc
CC	IEA	GO:0016021	integral component of membrane
CC	IEA	GO:0016323	basolateral plasma membrane
CC	IEA	GO:0016324	apical plasma membrane
CC	IBA	GO:0016342	catenin complex
CC	IDA	GO:0016342	catenin complex
CC	IBA	GO:0030027	lamellipodium
CC	IDA	GO:0030027	lamellipodium
CC	IDA	GO:0030054	cell junction
CC	IDA	GO:0030864	cortical actin cytoskeleton
CC	IEA	GO:0042383	sarcolemma
CC	IBA	GO:0042734	presynaptic membrane
CC	IBA	GO:0043005	neuron projection
CC	IEA	GO:0044853	plasma membrane raft
CC	IBA	GO:0045177	apical part of cell
CC	IBA	GO:0045202	synapse
CC	HDA	GO:0062023	collagen-containing extracellular matrix
CC	IBA	GO:0099059	integral component of presynaptic active zone membrane
CC	IBA	GO:0099060	integral component of postsynaptic specialization membrane
MF	IBA	GO:0005509	calcium ion binding
MF	IEA	GO:0005509	calcium ion binding
MF	IPI	GO:0005515	protein binding
MF	IPI	GO:0008013	beta-catenin binding
MF	TAS	GO:0008013	beta-catenin binding
MF	IBA	GO:0008092	cytoskeletal protein binding
MF	IEA	GO:0019901	protein kinase binding
MF	IEA	GO:0019903	protein phosphatase binding
MF	IEA	GO:0042802	identical protein binding
MF	IBA	GO:0042803	protein homodimerization activity
MF	IPI	GO:0045294	alpha-catenin binding
MF	IPI	GO:0045295	gamma-catenin binding
MF	IBA	GO:0045296	cadherin binding

Gene expression in normal tissue: CDH2

Select Project:

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in CDH2

Database	Pathway ID	Pathway Des.
reactome	R-HSA-1266738	Developmental Biology
reactome	R-HSA-1266738	Developmental Biology
reactome	R-HSA-1500931	Cell-Cell communication
reactome	R-HSA-375170	CDO in myogenesis
reactome	R-HSA-375170	CDO in myogenesis
reactome	R-HSA-381426	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
reactome	R-HSA-392499	Metabolism of proteins
reactome	R-HSA-418990	Adherens junctions interactions
reactome	R-HSA-421270	Cell-cell junction organization
reactome	R-HSA-446728	Cell junction organization
reactome	R-HSA-525793	Myogenesis
reactome	R-HSA-525793	Myogenesis
reactome	R-HSA-597592	Post-translational protein modification
reactome	R-HSA-8957275	Post-translational protein phosphorylation
wikipathways	WP2064	Neural Crest Differentiation
wikipathways	WP2118	Arrhythmogenic Right Ventricular Cardiomyopathy
wikipathways	WP2380	Brain-Derived Neurotrophic Factor (BDNF) signaling pathway
wikipathways	WP2572	Primary Focal Segmental Glomerulosclerosis FSGS
wikipathways	WP4148	Splicing factor NOVA regulated synaptic proteins
wikipathways	WP4239	EMT transition in Colorectal Cancer
kegg	hsa04514	Cell adhesion molecules (CAMs) - Homo sapiens (human)
kegg	hsa05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC) - Homo sapiens (human)
pid	ajdiss_2pathway	Posttranslational regulation of adherens junction stability and dissassembly
pid	fgf_pathway	FGF signaling pathway
pid	ncadherinpathway	N-cadherin signaling events
pid	ptp1bpathway	Signaling events mediated by PTP1B
netpath	Pathway_EGFR1	EGFR1

Gene-Drug: Aster Plot

Drug ID	Drug Name	Model Num.
iGMDRD367	Ro 28-1675	1
iGMDRD82	Quiflapon	5
iGMDRD322	FK 866	2
iGMDRD505	Pevonedistat	8
iGMDRD263	AACOCF3	1
iGMDRD5	Tyrphostin AG 1478	2
iGMDRD103	SN-38	2
iGMDRD271	Brefeldin A	3
iGMDRD121	GMX1778	4
iGMDRD415	LE-135	3
iGMDRD481	Dactolisib	5
iGMDRD105	Triptolide	3
iGMDRD57	Chloropentafluorobenzene	2
iGMDRD237	ABT-751	12
iGMDRD945	ML214	2
iGMDRD435	BI-2536	3
iGMDRD901	ELCPK	2
iGMDRD123	Isoevodiamine	2
iGMDRD584	VER 155008	1
iGMDRD84	Lovastatin acid	3
iGMDRD307	Manumycin A	3
iGMDRD523	Cyanoquinoline, 11	10
iGMDRD701	NVP-AUY922	2
iGMDRD424	Tamatinib	9
iGMDRD562	Navitoclax	4
iGMDRD780	PP-30	2
iGMDRD399	Selumetinib	2
iGMDRD60	Quinoclamine	9
iGMDRD64	Parbendazole	8
iGMDRD255	SB225002	2
iGMDRD613	CHEMBL258148	1
iGMDRD885	Compound 110	1
iGMDRD801	2,4-dideoxy-DC-45-A2	3
iGMDRD52	Rotenone	2
iGMDRD207	Capsaicin	1
iGMDRD446	LY 2183240	6
iGMDRD201	SKI II	2
iGMDRD394	BX-795	1
iGMDRD280	CYTOCHALASIN B	9
iGMDRD151	CHM-1	2
iGMDRD554	CHEMBL1434137	8
iGMDRD781	Sirolimus	1
iGMDRD427	ABT737	3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CDH2

SITE

DATATYPES

CLASSFICATION

Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.