CDH2
Summary: This gene encodes a classical cadherin and member of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein is proteolytically processed to generate a calcium-dependent cell adhesion molecule and glycoprotein. This protein plays a role in the establishment of left-right asymmetry, development of the nervous system and the formation of cartilage and bone. [provided by RefSeq, Nov 2015].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
Namecadherin 2 OMIM IDMIM:114020 Ensembl IDEnsembl:ENSG00000170558 HGNC IDHGNC:HGNC:1759 PHARMGKB IDPA26293 Map Location18q12.1 | |||||
GO terms in CDH2
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Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IBA | GO:0000902 | cell morphogenesis |
| BP | IBA | GO:0007043 | cell-cell junction assembly |
| BP | TAS | GO:0007155 | cell adhesion |
| BP | IBA | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules |
| BP | IEA | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules |
| BP | IEA | GO:0007157 | heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules |
Gene expression in normal tissue: CDH2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CDH2
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Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-1500931 | Cell-Cell communication |
| reactome | R-HSA-375170 | CDO in myogenesis |
| reactome | R-HSA-375170 | CDO in myogenesis |
| reactome | R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CDH2
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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