LMNB1
Summary: This gene encodes one of the two B-type lamin proteins and is a component of the nuclear lamina. A duplication of this gene is associated with autosomal dominant adult-onset leukodystrophy (ADLD). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| lamin B1 | MIM:150340 | Ensembl:ENSG00000113368 | HGNC:HGNC:6637 | PA30403 | 5q23.2 |
GO terms in LMNB1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0005198 | structural molecule activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0043274 | phospholipase binding |
| BP | TAS | GO:0035722 | interleukin-12-mediated signaling pathway |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005635 | nuclear envelope |
| CC | TAS | GO:0005635 | nuclear envelope |
| CC | IEA | GO:0005637 | nuclear inner membrane |
| CC | IEA | GO:0005638 | lamin filament |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | HDA | GO:0016020 | membrane |
| CC | IEA | GO:0016363 | nuclear matrix |
| CC | HDA | GO:0031965 | nuclear membrane |
| CC | IDA | GO:0031965 | nuclear membrane |
Gene expression in normal tissue: LMNB1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in LMNB1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-109581 | Apoptosis |
| reactome | R-HSA-111465 | Apoptotic cleavage of cellular proteins |
| reactome | R-HSA-1221632 | Meiotic synapsis |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-1474165 | Reproduction |
| reactome | R-HSA-1500620 | Meiosis |
| reactome | R-HSA-1640170 | Cell Cycle |
| reactome | R-HSA-1640170 | Cell Cycle |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-2262752 | Cellular responses to stress |
| reactome | R-HSA-2555396 | Mitotic Metaphase and Anaphase |
| reactome | R-HSA-2559583 | Cellular Senescence |
| reactome | R-HSA-2559584 | Formation of Senescence-Associated Heterochromatin Foci (SAHF) |
| reactome | R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence |
| reactome | R-HSA-2980766 | Nuclear Envelope Breakdown |
| reactome | R-HSA-2993913 | Clearance of Nuclear Envelope Membranes from Chromatin |
| reactome | R-HSA-2995383 | Initiation of Nuclear Envelope Reformation |
| reactome | R-HSA-2995410 | Nuclear Envelope Reassembly |
| reactome | R-HSA-352238 | Breakdown of the nuclear lamina |
| reactome | R-HSA-4419969 | Depolymerisation of the Nuclear Lamina |
| reactome | R-HSA-447115 | Interleukin-12 family signaling |
| reactome | R-HSA-449147 | Signaling by Interleukins |
| reactome | R-HSA-5357801 | Programmed Cell Death |
| reactome | R-HSA-68875 | Mitotic Prophase |
| reactome | R-HSA-68882 | Mitotic Anaphase |
| reactome | R-HSA-68886 | M Phase |
| reactome | R-HSA-69278 | Cell Cycle, Mitotic |
| reactome | R-HSA-75153 | Apoptotic execution phase |
| reactome | R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models |
| reactome | R-HSA-8863678 | Neurodegenerative Diseases |
| reactome | R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation |
| reactome | R-HSA-8953897 | Cellular responses to external stimuli |
| reactome | R-HSA-9020591 | Interleukin-12 signaling |
| biocarta | caspasepathway | caspase cascade in apoptosis |
| biocarta | hivnefpathway | hiv-1 nef: negative effector of fas and tnf |
| biocarta | tnfr1pathway | tnfr1 signaling pathway |
| pid | caspase_pathway | Caspase Cascade in Apoptosis |
| kegg | hsa04210 | Apoptosis - Homo sapiens (human) |
| wikipathways | WP314 | Fas Ligand (FasL) pathway and Stress induction of Heat Shock Proteins (HSP) regulation |
| wikipathways | WP4100 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD147 | Prima-1 | 1 |
| iGMDRD394 | BX-795 | 2 |
| iGMDRD280 | CYTOCHALASIN B | 5 |
| iGMDRD300 | Tozasertib | 2 |
| iGMDRD398 | Sepantronium | 3 |
| iGMDRD351 | GW843682X | 6 |
| iGMDRD523 | Cyanoquinoline, 11 | 3 |
| iGMDRD105 | Triptolide | 6 |
| iGMDRD255 | SB225002 | 3 |
| iGMDRD512 | nutlin 3 | 1 |
| iGMDRD158 | NSC141540 | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in LMNB1
CLASSFICATION
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.