UBE3B
Summary: The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: E1 ubiquitin-activating enzymes, E2 ubiquitin-conjugating enzymes, and E3 ubiquitin-protein ligases. This gene encodes a member of the E3 ubiquitin-conjugating enzyme family which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme and transfers the ubiquitin to the targeted substrates. A HECT (homology to E6-AP C-terminus) domain in the C-terminus of the longer isoform of this protein is the catalytic site of ubiquitin transfer and forms a complex with E2 conjugases. Shorter isoforms of this protein which lack the C-terminal HECT domain are therefore unlikely to bind E2 enzymes. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2012].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
ubiquitin protein ligase E3B | MIM:608047 | Ensembl:ENSG00000151148 | HGNC:HGNC:13478 | PA134872189 | 12q24.11 |
GO terms in UBE3B
Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
BP | IBA | GO:0000209 | protein polyubiquitination |
BP | IEA | GO:0016567 | protein ubiquitination |
MF | IBA | GO:0061631 | ubiquitin conjugating enzyme activity |
Gene expression in normal tissue: UBE3B
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in UBE3B
Database | Pathway ID | Pathway Des. |
---|---|---|
kegg | hsa04120 | Ubiquitin mediated proteolysis - Homo sapiens (human) |
reactome | R-HSA-1280218 | Adaptive Immune System |
reactome | R-HSA-168256 | Immune System |
reactome | R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation |
reactome | R-HSA-983169 | Class I MHC mediated antigen processing & presentation |
Gene-Drug: Aster Plot
Drug ID | Drug Name | Model Num. |
---|---|---|
iGMDRD351 | GW843682X | 3 |
iGMDRD152 | 179324-69-7 | 3 |
iGMDRD61 | Kinetin riboside | 3 |
iGMDRD280 | CYTOCHALASIN B | 3 |
iGMDRD359 | OSW-1 | 3 |
iGMDRD126 | Tipifarnib | 2 |
iGMDRD148 | Pifithrin-mu | 1 |
iGMDRD1008 | SR-II-138A | 3 |
iGMDRD116 | CD437 | 3 |
iGMDRD560 | MK-2206 | 2 |
iGMDRD546 | BMS-754807 | 3 |
iGMDRD427 | ABT737 | 3 |
iGMDRD424 | Tamatinib | 2 |
iGMDRD523 | Cyanoquinoline, 11 | 3 |
iGMDRD781 | Sirolimus | 3 |
iGMDRD484 | Pluripotin | 2 |
iGMDRD872 | BRD7137 | 3 |
iGMDRD399 | Selumetinib | 3 |
iGMDRD398 | Sepantronium | 2 |
iGMDRD369 | TGX-115 | 2 |
iGMDRD524 | ISX-9 | 6 |
iGMDRD121 | GMX1778 | 1 |
iGMDRD202 | Curcumin | 1 |
iGMDRD227 | Fatostatin A | 3 |
iGMDRD705 | Nakiterpiosin | 2 |
iGMDRD434 | BMS-536924 | 4 |
iGMDRD885 | Compound 110 | 6 |
iGMDRD481 | Dactolisib | 3 |
iGMDRD318 | PAC-1 | 2 |
iGMDRD77 | Itraconazole | 2 |
iGMDRD267 | Oligomycin A | 3 |
Gene in drug-gene network: Network Plot
![](image/gene_network_legends.png)
Gene-drug targets distribution
Gene Structure: PDB
Models in UBE3B