PHKG1
Summary: This gene is a member of the Ser/Thr protein kinase family and encodes a protein with one protein kinase domain and two calmodulin-binding domains. This protein is the catalytic member of a 16 subunit protein kinase complex which contains equimolar ratios of 4 subunit types. The complex is a crucial glycogenolytic regulatory enzyme. This gene has two pseudogenes at chromosome 7q11.21 and one at chromosome 11p11.12. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| phosphorylase kinase catalytic subunit gamma 1 | MIM:172470 | Ensembl:ENSG00000164776 | HGNC:HGNC:8930 | PA33271 | 7p11.2 |
GO terms in PHKG1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0004683 | calmodulin-dependent protein kinase activity |
| MF | IBA | GO:0005516 | calmodulin binding |
| MF | IEA | GO:0005516 | calmodulin binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IEA | GO:0019899 | enzyme binding |
| MF | IEA | GO:0050321 | tau-protein kinase activity |
| BP | NAS | GO:0005975 | carbohydrate metabolic process |
| BP | IEA | GO:0005978 | glycogen biosynthetic process |
| CC | TAS | GO:0005829 | cytosol |
Gene expression in normal tissue: PHKG1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PHKG1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-70221 | Glycogen breakdown (glycogenolysis) |
| reactome | R-HSA-70221 | Glycogen breakdown (glycogenolysis) |
| reactome | R-HSA-71387 | Metabolism of carbohydrates |
| reactome | R-HSA-71387 | Metabolism of carbohydrates |
| reactome | R-HSA-8982491 | Glycogen metabolism |
| reactome | R-HSA-8982491 | Glycogen metabolism |
| wikipathways | WP500 | Glycogen Metabolism |
| kegg | hsa04020 | Calcium signaling pathway - Homo sapiens (human) |
| kegg | hsa04910 | Insulin signaling pathway - Homo sapiens (human) |
| kegg | hsa04922 | Glucagon signaling pathway - Homo sapiens (human) |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD289 | Parthenolide | 3 |
| iGMDRD286 | Nsc 632839 | 6 |
| iGMDRD872 | BRD7137 | 3 |
| iGMDRD329 | Merck60 | 2 |
| iGMDRD269 | Purmorphamine | 1 |
| iGMDRD505 | Pevonedistat | 7 |
| iGMDRD300 | Tozasertib | 1 |
| iGMDRD82 | Quiflapon | 5 |
| iGMDRD512 | nutlin 3 | 4 |
| iGMDRD150 | RITA | 3 |
| iGMDRD424 | Tamatinib | 10 |
| iGMDRD523 | Cyanoquinoline, 11 | 10 |
| iGMDRD237 | ABT-751 | 5 |
| iGMDRD123 | Isoevodiamine | 1 |
| iGMDRD154 | NSC23766 | 4 |
| iGMDRD945 | ML214 | 3 |
| iGMDRD255 | SB225002 | 3 |
| iGMDRD885 | Compound 110 | 3 |
| iGMDRD188 | Piperlongumine | 1 |
| iGMDRD577 | BIX01294 | 2 |
| iGMDRD506 | Fedratinib | 3 |
| iGMDRD562 | Navitoclax | 5 |
| iGMDRD64 | Parbendazole | 6 |
| iGMDRD60 | Quinoclamine | 13 |
| iGMDRD268 | Cerulenin | 1 |
| iGMDRD554 | CHEMBL1434137 | 8 |
| iGMDRD144 | NSC95397 | 1 |
| iGMDRD781 | Sirolimus | 3 |
| iGMDRD446 | LY 2183240 | 6 |
| iGMDRD280 | CYTOCHALASIN B | 10 |
| iGMDRD466 | Chaetocin | 3 |
| iGMDRD634 | SCHEMBL2608041 | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PHKG1
CLASSFICATION
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