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PHKG1

Summary: This gene is a member of the Ser/Thr protein kinase family and encodes a protein with one protein kinase domain and two calmodulin-binding domains. This protein is the catalytic member of a 16 subunit protein kinase complex which contains equimolar ratios of 4 subunit types. The complex is a crucial glycogenolytic regulatory enzyme. This gene has two pseudogenes at chromosome 7q11.21 and one at chromosome 11p11.12. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012].

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Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
Namephosphorylase kinase catalytic subunit gamma 1 OMIM IDMIM:172470 Ensembl IDEnsembl:ENSG00000164776 HGNC IDHGNC:HGNC:8930 PHARMGKB IDPA33271 Map Location7p11.2

Gene Categories:

DRUGGABLE GENOME SERINE THREONINE KINASE KINASE

GO terms in PHKG1

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Term Type	Evidence Type	GO Term ID	GO Des.
MF	IBA	GO:0004683	calmodulin-dependent protein kinase activity
MF	IBA	GO:0005516	calmodulin binding
MF	IEA	GO:0005516	calmodulin binding
MF	IEA	GO:0005524	ATP binding
MF	IEA	GO:0019899	enzyme binding
MF	IEA	GO:0050321	tau-protein kinase activity

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Gene expression in normal tissue: PHKG1

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in PHKG1

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Database	Pathway ID	Pathway Des.
reactome	R-HSA-1430728	Metabolism
reactome	R-HSA-1430728	Metabolism
reactome	R-HSA-70221	Glycogen breakdown (glycogenolysis)
reactome	R-HSA-70221	Glycogen breakdown (glycogenolysis)
reactome	R-HSA-71387	Metabolism of carbohydrates
reactome	R-HSA-71387	Metabolism of carbohydrates

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Gene-Drug: Aster Plot

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Drug ID	Drug Name	Model Num.
iGMDRD289	Parthenolide	3
iGMDRD286	Nsc 632839	6
iGMDRD872	BRD7137	3
iGMDRD329	Merck60	2

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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PHKG1

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	Model	Level	Reference ID	Tissue	Cancer	Drug	Clinical Response	Source
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