NR3C1
Summary: This gene encodes glucocorticoid receptor, which can function both as a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their transcription, and as a regulator of other transcription factors. This receptor is typically found in the cytoplasm, but upon ligand binding, is transported into the nucleus. It is involved in inflammatory responses, cellular proliferation, and differentiation in target tissues. Mutations in this gene are associated with generalized glucocorticoid resistance. Alternative splicing of this gene results in transcript variants encoding either the same or different isoforms. Additional isoforms resulting from the use of alternate in-frame translation initiation sites have also been described, and shown to be functional, displaying diverse cytoplasm-to-nucleus trafficking patterns and distinct transcriptional activities (PMID:15866175). [provided by RefSeq, Feb 2011].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| nuclear receptor subfamily 3 group C member 1 | MIM:138040 | Ensembl:ENSG00000113580 | HGNC:HGNC:7978 | PA181 | 5q31.3 |
GO terms in NR3C1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IDA | GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding |
| MF | ISA | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | ISM | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | NAS | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | IDA | GO:0001047 | core promoter binding |
| MF | IDA | GO:0001077 | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding |
| MF | IDA | GO:0003700 | DNA-binding transcription factor activity |
| MF | IEA | GO:0003723 | RNA binding |
| MF | TAS | GO:0004883 | glucocorticoid receptor activity |
| MF | IDA | GO:0005496 | steroid binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0008270 | zinc ion binding |
| MF | IPI | GO:0019901 | protein kinase binding |
| MF | IPI | GO:0032183 | SUMO binding |
| MF | IPI | GO:0051879 | Hsp90 protein binding |
| MF | IDA | GO:1990239 | steroid hormone binding |
| BP | IMP | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0006325 | chromatin organization |
| BP | IDA | GO:0006351 | transcription, DNA-templated |
| BP | IDA | GO:0006355 | regulation of transcription, DNA-templated |
| BP | TAS | GO:0006366 | transcription by RNA polymerase II |
| BP | TAS | GO:0006367 | transcription initiation from RNA polymerase II promoter |
| BP | IEA | GO:0006915 | apoptotic process |
| BP | IEA | GO:0007049 | cell cycle |
| BP | IEA | GO:0007059 | chromosome segregation |
| BP | TAS | GO:0007165 | signal transduction |
| BP | IEA | GO:0042921 | glucocorticoid receptor signaling pathway |
| BP | IEA | GO:0043402 | glucocorticoid mediated signaling pathway |
| BP | IDA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IMP | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0051301 | cell division |
| BP | IDA | GO:0071383 | cellular response to steroid hormone stimulus |
| BP | IDA | GO:0071385 | cellular response to glucocorticoid stimulus |
| BP | IMP | GO:0071549 | cellular response to dexamethasone stimulus |
| BP | IDA | GO:0071560 | cellular response to transforming growth factor beta stimulus |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | TAS | GO:0005759 | mitochondrial matrix |
| CC | IEA | GO:0005815 | microtubule organizing center |
| CC | IEA | GO:0005819 | spindle |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | IDA | GO:0016607 | nuclear speck |
| CC | IDA | GO:0032991 | protein-containing complex |
Gene expression in normal tissue: NR3C1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in NR3C1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| pharmgkb | PA2027 | Glucocorticoid Pathway (Peripheral Tissue), Pharmacodynamics |
| pid | ap1_pathway | AP-1 transcription factor network |
| pid | ar_tf_pathway | Regulation of Androgen receptor activity |
| pid | hdac_classii_pathway | Signaling events mediated by HDAC Class II |
| pid | hnf3bpathway | FOXA2 and FOXA3 transcription factor networks |
| pid | reg_gr_pathway | Glucocorticoid receptor regulatory network |
| pid | smad2_3nuclearpathway | Regulation of nuclear SMAD2/3 signaling |
| wikipathways | WP170 | Nuclear Receptors |
| wikipathways | WP236 | Adipogenesis |
| wikipathways | WP2853 | Endoderm Differentiation |
| wikipathways | WP2880 | Glucocorticoid Receptor Pathway |
| wikipathways | WP2882 | Nuclear Receptors Meta-Pathway |
| wikipathways | WP3599 | Transcription factor regulation in adipogenesis |
| wikipathways | WP3946 | White fat cell differentiation |
| wikipathways | WP4149 | White fat cell differentiation |
| wikipathways | WP706 | Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways |
| wikipathways | WP734 | Serotonin Receptor 4-6-7 and NR3C Signaling |
| smpdb | SMP00441 | Prednisolone Action Pathway |
| smpdb | SMP00632 | Prednisolone Metabolism Pathway |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-2262752 | Cellular responses to stress |
| reactome | R-HSA-2990846 | SUMOylation |
| reactome | R-HSA-3108232 | SUMO E3 ligases SUMOylate target proteins |
| reactome | R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) |
| reactome | R-HSA-383280 | Nuclear Receptor transcription pathway |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-400253 | Circadian Clock |
| reactome | R-HSA-4090294 | SUMOylation of intracellular receptors |
| reactome | R-HSA-597592 | Post-translational protein modification |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-8848021 | Signaling by PTK6 |
| reactome | R-HSA-8849473 | PTK6 Expression |
| reactome | R-HSA-8878166 | Transcriptional regulation by RUNX2 |
| reactome | R-HSA-8939902 | Regulation of RUNX2 expression and activity |
| reactome | R-HSA-8953897 | Cellular responses to external stimuli |
| reactome | R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases |
| biocarta | carmerpathway | carm1 and regulation of the estrogen receptor |
| biocarta | gcrpathway | corticosteroids and cardioprotection |
| biocarta | hswisnfpathway | chromatin remodeling by hswi/snf atp-dependent complexes |
| biocarta | nthipathway | nfkb activation by nontypeable hemophilus influenzae |
| biocarta | pcafpathway | the information processing pathway at the ifn beta enhancer |
| biocarta | rnapol3pathway | rna polymerase iii transcription |
| biocarta | vobesitypathway | visceral fat deposits and the metabolic syndrome |
| kegg | hsa04080 | Neuroactive ligand-receptor interaction - Homo sapiens (human) |
| netpath | Pathway_IL2 | IL2 |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD351 | GW843682X | 3 |
| iGMDRD61 | Kinetin riboside | 2 |
| iGMDRD193 | Fqi1 | 1 |
| iGMDRD307 | Manumycin A | 1 |
| iGMDRD420 | Leucascandrolide A | 2 |
| iGMDRD546 | BMS-754807 | 2 |
| iGMDRD494 | Neopeltolide | 3 |
| iGMDRD523 | Cyanoquinoline, 11 | 1 |
| iGMDRD405 | PIK-75 | 2 |
| iGMDRD871 | BRD6368 | 2 |
| iGMDRD329 | Merck60 | 4 |
| iGMDRD366 | PI-103 | 4 |
| iGMDRD64 | Parbendazole | 2 |
| iGMDRD23 | Gossypol | 2 |
| iGMDRD491 | TAE-684 | 1 |
| iGMDRD202 | Curcumin | 4 |
| iGMDRD121 | GMX1778 | 2 |
| iGMDRD137 | Indisulam | 2 |
| iGMDRD255 | SB225002 | 2 |
| iGMDRD434 | BMS-536924 | 3 |
| iGMDRD481 | Dactolisib | 4 |
| iGMDRD187 | BRD9876 | 2 |
| iGMDRD870 | BRD63610 | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in NR3C1
CLASSFICATION
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