NR3C1


Summary: This gene encodes glucocorticoid receptor, which can function both as a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their transcription, and as a regulator of other transcription factors. This receptor is typically found in the cytoplasm, but upon ligand binding, is transported into the nucleus. It is involved in inflammatory responses, cellular proliferation, and differentiation in target tissues. Mutations in this gene are associated with generalized glucocorticoid resistance. Alternative splicing of this gene results in transcript variants encoding either the same or different isoforms. Additional isoforms resulting from the use of alternate in-frame translation initiation sites have also been described, and shown to be functional, displaying diverse cytoplasm-to-nucleus trafficking patterns and distinct transcriptional activities (PMID:15866175). [provided by RefSeq, Feb 2011].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
nuclear receptor subfamily 3 group C member 1MIM:138040Ensembl:ENSG00000113580HGNC:HGNC:7978PA1815q31.3

GO terms in NR3C1


Term TypeEvidence TypeGO Term IDGO Des.
MFIDAGO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding
MFISAGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFISMGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFNASGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFIDAGO:0001047core promoter binding
MFIDAGO:0001077transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding
MFIDAGO:0003700DNA-binding transcription factor activity
MFIEAGO:0003723RNA binding
MFTASGO:0004883glucocorticoid receptor activity
MFIDAGO:0005496steroid binding
MFIPIGO:0005515protein binding
MFIEAGO:0008270zinc ion binding
MFIPIGO:0019901protein kinase binding
MFIPIGO:0032183SUMO binding
MFIPIGO:0051879Hsp90 protein binding
MFIDAGO:1990239steroid hormone binding
BPIMPGO:0000122negative regulation of transcription by RNA polymerase II
BPIEAGO:0006325chromatin organization
BPIDAGO:0006351transcription, DNA-templated
BPIDAGO:0006355regulation of transcription, DNA-templated
BPTASGO:0006366transcription by RNA polymerase II
BPTASGO:0006367transcription initiation from RNA polymerase II promoter
BPIEAGO:0006915apoptotic process
BPIEAGO:0007049cell cycle
BPIEAGO:0007059chromosome segregation
BPTASGO:0007165signal transduction
BPIEAGO:0042921glucocorticoid receptor signaling pathway
BPIEAGO:0043402glucocorticoid mediated signaling pathway
BPIDAGO:0045944positive regulation of transcription by RNA polymerase II
BPIMPGO:0045944positive regulation of transcription by RNA polymerase II
BPIEAGO:0051301cell division
BPIDAGO:0071383cellular response to steroid hormone stimulus
BPIDAGO:0071385cellular response to glucocorticoid stimulus
BPIMPGO:0071549cellular response to dexamethasone stimulus
BPIDAGO:0071560cellular response to transforming growth factor beta stimulus
CCIDAGO:0005634nucleus
CCIDAGO:0005654nucleoplasm
CCTASGO:0005654nucleoplasm
CCIDAGO:0005737cytoplasm
CCTASGO:0005759mitochondrial matrix
CCIEAGO:0005815microtubule organizing center
CCIEAGO:0005819spindle
CCIDAGO:0005829cytosol
CCTASGO:0005829cytosol
CCIDAGO:0016607nuclear speck
CCIDAGO:0032991protein-containing complex

Gene expression in normal tissue: NR3C1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in NR3C1


DatabasePathway IDPathway Des.
pharmgkbPA2027Glucocorticoid Pathway (Peripheral Tissue), Pharmacodynamics
pidap1_pathwayAP-1 transcription factor network
pidar_tf_pathwayRegulation of Androgen receptor activity
pidhdac_classii_pathwaySignaling events mediated by HDAC Class II
pidhnf3bpathwayFOXA2 and FOXA3 transcription factor networks
pidreg_gr_pathwayGlucocorticoid receptor regulatory network
pidsmad2_3nuclearpathwayRegulation of nuclear SMAD2/3 signaling
wikipathwaysWP170Nuclear Receptors
wikipathwaysWP236Adipogenesis
wikipathwaysWP2853Endoderm Differentiation
wikipathwaysWP2880Glucocorticoid Receptor Pathway
wikipathwaysWP2882Nuclear Receptors Meta-Pathway
wikipathwaysWP3599Transcription factor regulation in adipogenesis
wikipathwaysWP3946White fat cell differentiation
wikipathwaysWP4149White fat cell differentiation
wikipathwaysWP706Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways
wikipathwaysWP734Serotonin Receptor 4-6-7 and NR3C Signaling
smpdbSMP00441Prednisolone Action Pathway
smpdbSMP00632Prednisolone Metabolism Pathway
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-212436Generic Transcription Pathway
reactomeR-HSA-212436Generic Transcription Pathway
reactomeR-HSA-2262752Cellular responses to stress
reactomeR-HSA-2990846SUMOylation
reactomeR-HSA-3108232SUMO E3 ligases SUMOylate target proteins
reactomeR-HSA-3371497HSP90 chaperone cycle for steroid hormone receptors (SHR)
reactomeR-HSA-383280Nuclear Receptor transcription pathway
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-400253Circadian Clock
reactomeR-HSA-4090294SUMOylation of intracellular receptors
reactomeR-HSA-597592Post-translational protein modification
reactomeR-HSA-73857RNA Polymerase II Transcription
reactomeR-HSA-73857RNA Polymerase II Transcription
reactomeR-HSA-74160Gene expression (Transcription)
reactomeR-HSA-74160Gene expression (Transcription)
reactomeR-HSA-8848021Signaling by PTK6
reactomeR-HSA-8849473PTK6 Expression
reactomeR-HSA-8878166Transcriptional regulation by RUNX2
reactomeR-HSA-8939902Regulation of RUNX2 expression and activity
reactomeR-HSA-8953897Cellular responses to external stimuli
reactomeR-HSA-9006927Signaling by Non-Receptor Tyrosine Kinases
biocartacarmerpathwaycarm1 and regulation of the estrogen receptor
biocartagcrpathwaycorticosteroids and cardioprotection
biocartahswisnfpathwaychromatin remodeling by hswi/snf atp-dependent complexes
biocartanthipathwaynfkb activation by nontypeable hemophilus influenzae
biocartapcafpathwaythe information processing pathway at the ifn beta enhancer
biocartarnapol3pathwayrna polymerase iii transcription
biocartavobesitypathwayvisceral fat deposits and the metabolic syndrome
kegghsa04080Neuroactive ligand-receptor interaction - Homo sapiens (human)
netpathPathway_IL2IL2

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD351GW843682X3
iGMDRD61Kinetin riboside2
iGMDRD193Fqi11
iGMDRD307Manumycin A1
iGMDRD420Leucascandrolide A2
iGMDRD546BMS-7548072
iGMDRD494Neopeltolide3
iGMDRD523Cyanoquinoline, 111
iGMDRD405PIK-752
iGMDRD871BRD63682
iGMDRD329Merck604
iGMDRD366PI-1034
iGMDRD64Parbendazole2
iGMDRD23Gossypol2
iGMDRD491TAE-6841
iGMDRD202Curcumin4
iGMDRD121GMX17782
iGMDRD137Indisulam2
iGMDRD255SB2250022
iGMDRD434BMS-5369243
iGMDRD481Dactolisib4
iGMDRD187BRD98762
iGMDRD870BRD636102

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in NR3C1

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