NR3C1

Summary: This gene encodes glucocorticoid receptor, which can function both as a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their transcription, and as a regulator of other transcription factors. This receptor is typically found in the cytoplasm, but upon ligand binding, is transported into the nucleus. It is involved in inflammatory responses, cellular proliferation, and differentiation in target tissues. Mutations in this gene are associated with generalized glucocorticoid resistance. Alternative splicing of this gene results in transcript variants encoding either the same or different isoforms. Additional isoforms resulting from the use of alternate in-frame translation initiation sites have also been described, and shown to be functional, displaying diverse cytoplasm-to-nucleus trafficking patterns and distinct transcriptional activities (PMID:15866175). [provided by RefSeq, Feb 2011].

Loading, please wait...
Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Namenuclear receptor subfamily 3 group C member 1
OMIM IDMIM:138040
Ensembl IDEnsembl:ENSG00000113580
HGNC IDHGNC:HGNC:7978
PHARMGKB IDPA181
Map Location5q31.3

GO terms in NR3C1


Loading, please wait...
Term Type
Evidence Type
GO Term ID
GO Des.
MF IDA GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding
MF ISA GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
MF ISM GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
MF NAS GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
MF IDA GO:0001047 core promoter binding
MF IDA GO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding
Showing 1 to 6 of 46 rows rows per page

Gene expression in normal tissue: NR3C1

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 34LUNtissue: LUN cancer: LUNG model num: 0LUNGtissue: LUNG cancer: undefined model num: 5BOWEtissue: BOWE cancer: BOWEL model num: 0BOWELtissue: BOWEL cancer: undefined model num: 14

Gene-drug pathway distribution

undefined16PI3K/MTOR signaling2Stilbenoid, diarylheptanoid and gingerol biosynthesis1RTK signaling1Biosynthesis of secondary metabolites1Cell cycle1IGFR signaling1

Pathways in NR3C1


Loading, please wait...
Database
Pathway ID
Pathway Des.
pharmgkb PA2027 Glucocorticoid Pathway (Peripheral Tissue), Pharmacodynamics
pid ap1_pathway AP-1 transcription factor network
pid ar_tf_pathway Regulation of Androgen receptor activity
pid hdac_classii_pathway Signaling events mediated by HDAC Class II
pid hnf3bpathway FOXA2 and FOXA3 transcription factor networks
pid reg_gr_pathway Glucocorticoid receptor regulatory network
Showing 1 to 6 of 50 rows rows per page

Gene-Drug: Aster Plot


Loading, please wait...
Drug ID
Drug Name
Model Num.
iGMDRD351 GW843682X 3
iGMDRD61 Kinetin riboside 2
iGMDRD193 Fqi1 1
iGMDRD307 Manumycin A 1
Showing 1 to 4 of 23 rows rows per page

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in NR3C1

Loading, please wait...
Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

​​​​

SITE
DATATYPES
CLASSFICATION
Map

Copyright © 2018 Modellab | All Rights Reserved

Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.