ARFGEF1

Summary: ADP-ribosylation factors (ARFs) play an important role in intracellular vesicular trafficking. The protein encoded by this gene is involved in the activation of ARFs by accelerating replacement of bound GDP with GTP. It contains a Sec7 domain, which may be responsible for guanine-nucleotide exchange activity and also brefeldin A inhibition. [provided by RefSeq, Aug 2011].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
NameADP ribosylation factor guanine nucleotide exchange factor 1
OMIM IDMIM:604141
Ensembl IDEnsembl:ENSG00000066777
HGNC IDHGNC:HGNC:15772
PHARMGKB IDPA134908197
Map Location8q13.2

GO terms in ARFGEF1


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IDA GO:0005085 guanyl-nucleotide exchange factor activity
MF IBA GO:0005086 ARF guanyl-nucleotide exchange factor activity
MF IDA GO:0005096 GTPase activator activity
MF IPI GO:0005515 protein binding
MF IPI GO:0017022 myosin binding
MF IDA GO:0034237 protein kinase A regulatory subunit binding
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Gene expression in normal tissue: ARFGEF1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in ARFGEF1


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Database
Pathway ID
Pathway Des.
kegg hsa04144 Endocytosis - Homo sapiens (human)
biocarta arappathway adp-ribosylation factor
biocarta par1pathway thrombin signaling and protease-activated receptors
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD679 Bistramide A 6
iGMDRD394 BX-795 1
iGMDRD639 YK 4-279 2
iGMDRD193 Fqi1 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ARFGEF1

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
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