AGAP2
Summary: The protein encoded by this gene belongs to the centaurin gamma-like family. It mediates anti-apoptotic effects of nerve growth factor by activating nuclear phosphoinositide 3-kinase. It is overexpressed in cancer cells, and promotes cancer cell invasion. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 | MIM:605476 | Ensembl:ENSG00000135439 | HGNC:HGNC:16921 | PA26411 | 12q14.1 |
GO terms in AGAP2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | TAS | GO:0003924 | GTPase activity |
| MF | IEA | GO:0005096 | GTPase activator activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005525 | GTP binding |
| MF | IEA | GO:0046872 | metal ion binding |
| BP | IEA | GO:0015031 | protein transport |
| BP | IDA | GO:0042177 | negative regulation of protein catabolic process |
| BP | IGI | GO:0043524 | negative regulation of neuron apoptotic process |
| BP | IEA | GO:0043547 | positive regulation of GTPase activity |
| BP | TAS | GO:0061903 | positive regulation of 1-phosphatidylinositol-3-kinase activity |
| CC | IBA | GO:0005634 | nucleus |
| CC | IDA | GO:0005634 | nucleus |
| CC | ISS | GO:0005634 | nucleus |
| CC | TAS | GO:0005634 | nucleus |
| CC | IDA | GO:0005730 | nucleolus |
| CC | TAS | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005739 | mitochondrion |
| CC | HDA | GO:0016020 | membrane |
| CC | HDA | GO:0070062 | extracellular exosome |
Gene expression in normal tissue: AGAP2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in AGAP2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP2037 | Prolactin Signaling Pathway |
| wikipathways | WP2593 | JAK-STAT |
| kegg | hsa04068 | FoxO signaling pathway - Homo sapiens (human) |
| kegg | hsa04144 | Endocytosis - Homo sapiens (human) |
| pid | netrin_pathway | Netrin-mediated signaling events |
| pid | pi3kplctrkpathway | Trk receptor signaling mediated by PI3K and PLC-gamma |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-373752 | Netrin-1 signaling |
| reactome | R-HSA-422475 | Axon guidance |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD781 | Sirolimus | 2 |
| iGMDRD494 | Neopeltolide | 4 |
| iGMDRD151 | CHM-1 | 4 |
| iGMDRD579 | PF750 | 4 |
| iGMDRD420 | Leucascandrolide A | 5 |
| iGMDRD772 | BRD4770 | 3 |
| iGMDRD280 | CYTOCHALASIN B | 2 |
| iGMDRD193 | Fqi1 | 2 |
| iGMDRD639 | YK 4-279 | 3 |
| iGMDRD52 | Rotenone | 4 |
| iGMDRD318 | PAC-1 | 1 |
| iGMDRD260 | FQI-2 | 2 |
| iGMDRD64 | Parbendazole | 2 |
| iGMDRD60 | Quinoclamine | 3 |
| iGMDRD399 | Selumetinib | 1 |
| iGMDRD562 | Navitoclax | 2 |
| iGMDRD424 | Tamatinib | 2 |
| iGMDRD560 | MK-2206 | 3 |
| iGMDRD523 | Cyanoquinoline, 11 | 2 |
| iGMDRD512 | nutlin 3 | 2 |
| iGMDRD901 | ELCPK | 2 |
| iGMDRD883 | CIL55A | 1 |
| iGMDRD435 | BI-2536 | 4 |
| iGMDRD314 | Tanespimycin | 1 |
| iGMDRD267 | Oligomycin A | 4 |
| iGMDRD77 | Itraconazole | 5 |
| iGMDRD158 | NSC141540 | 1 |
| iGMDRD505 | Pevonedistat | 1 |
| iGMDRD300 | Tozasertib | 2 |
| iGMDRD871 | BRD6368 | 3 |
| iGMDRD662 | JQ-1 | 2 |
| iGMDRD329 | Merck60 | 4 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in AGAP2
CLASSFICATION
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