AGAP2

Summary: The protein encoded by this gene belongs to the centaurin gamma-like family. It mediates anti-apoptotic effects of nerve growth factor by activating nuclear phosphoinositide 3-kinase. It is overexpressed in cancer cells, and promotes cancer cell invasion. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
NameArfGAP with GTPase domain, ankyrin repeat and PH domain 2
OMIM IDMIM:605476
Ensembl IDEnsembl:ENSG00000135439
HGNC IDHGNC:HGNC:16921
PHARMGKB IDPA26411
Map Location12q14.1

GO terms in AGAP2


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Term Type
Evidence Type
GO Term ID
GO Des.
MF TAS GO:0003924 GTPase activity
MF IEA GO:0005096 GTPase activator activity
MF IPI GO:0005515 protein binding
MF IEA GO:0005525 GTP binding
MF IEA GO:0046872 metal ion binding
BP IEA GO:0015031 protein transport
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Gene expression in normal tissue: AGAP2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

undefined21Apoptosis regulation2DNA replication1Mitosis1Chromatin other1Protein stability and degradation1PI3K/MTOR signaling1Biosynthesis of secondary metabolites1ERK MAPK signaling1Longevity regulating pathway1

Pathways in AGAP2


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Database
Pathway ID
Pathway Des.
wikipathways WP2037 Prolactin Signaling Pathway
wikipathways WP2593 JAK-STAT
kegg hsa04068 FoxO signaling pathway - Homo sapiens (human)
kegg hsa04144 Endocytosis - Homo sapiens (human)
pid netrin_pathway Netrin-mediated signaling events
pid pi3kplctrkpathway Trk receptor signaling mediated by PI3K and PLC-gamma
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD781 Sirolimus 2
iGMDRD494 Neopeltolide 4
iGMDRD151 CHM-1 4
iGMDRD579 PF750 4
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in AGAP2

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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