AGAP2


Summary: The protein encoded by this gene belongs to the centaurin gamma-like family. It mediates anti-apoptotic effects of nerve growth factor by activating nuclear phosphoinositide 3-kinase. It is overexpressed in cancer cells, and promotes cancer cell invasion. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
ArfGAP with GTPase domain, ankyrin repeat and PH domain 2MIM:605476Ensembl:ENSG00000135439HGNC:HGNC:16921PA2641112q14.1

GO terms in AGAP2


Term TypeEvidence TypeGO Term IDGO Des.
MFTASGO:0003924GTPase activity
MFIEAGO:0005096GTPase activator activity
MFIPIGO:0005515protein binding
MFIEAGO:0005525GTP binding
MFIEAGO:0046872metal ion binding
BPIEAGO:0015031protein transport
BPIDAGO:0042177negative regulation of protein catabolic process
BPIGIGO:0043524negative regulation of neuron apoptotic process
BPIEAGO:0043547positive regulation of GTPase activity
BPTASGO:0061903positive regulation of 1-phosphatidylinositol-3-kinase activity
CCIBAGO:0005634nucleus
CCIDAGO:0005634nucleus
CCISSGO:0005634nucleus
CCTASGO:0005634nucleus
CCIDAGO:0005730nucleolus
CCTASGO:0005737cytoplasm
CCIDAGO:0005739mitochondrion
CCHDAGO:0016020membrane
CCHDAGO:0070062extracellular exosome

Gene expression in normal tissue: AGAP2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in AGAP2


DatabasePathway IDPathway Des.
wikipathwaysWP2037Prolactin Signaling Pathway
wikipathwaysWP2593JAK-STAT
kegghsa04068FoxO signaling pathway - Homo sapiens (human)
kegghsa04144Endocytosis - Homo sapiens (human)
pidnetrin_pathwayNetrin-mediated signaling events
pidpi3kplctrkpathwayTrk receptor signaling mediated by PI3K and PLC-gamma
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-373752Netrin-1 signaling
reactomeR-HSA-422475Axon guidance

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD781Sirolimus2
iGMDRD494Neopeltolide4
iGMDRD151CHM-14
iGMDRD579PF7504
iGMDRD420Leucascandrolide A5
iGMDRD772BRD47703
iGMDRD280CYTOCHALASIN B2
iGMDRD193Fqi12
iGMDRD639YK 4-2793
iGMDRD52Rotenone4
iGMDRD318PAC-11
iGMDRD260FQI-22
iGMDRD64Parbendazole2
iGMDRD60Quinoclamine3
iGMDRD399Selumetinib1
iGMDRD562Navitoclax2
iGMDRD424Tamatinib2
iGMDRD560MK-22063
iGMDRD523Cyanoquinoline, 112
iGMDRD512nutlin 32
iGMDRD901ELCPK2
iGMDRD883CIL55A1
iGMDRD435BI-25364
iGMDRD314Tanespimycin1
iGMDRD267Oligomycin A4
iGMDRD77Itraconazole5
iGMDRD158NSC1415401
iGMDRD505Pevonedistat1
iGMDRD300Tozasertib2
iGMDRD871BRD63683
iGMDRD662JQ-12
iGMDRD329Merck604

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in AGAP2

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