INPP5D


Summary: This gene is a member of the inositol polyphosphate-5-phosphatase (INPP5) family and encodes a protein with an N-terminal SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains. Expression of this protein is restricted to hematopoietic cells where its movement from the cytosol to the plasma membrane is mediated by tyrosine phosphorylation. At the plasma membrane, the protein hydrolyzes the 5' phosphate from phosphatidylinositol (3,4,5)-trisphosphate and inositol-1,3,4,5-tetrakisphosphate, thereby affecting multiple signaling pathways. The protein is also partly localized to the nucleus, where it may be involved in nuclear inositol phosphate signaling processes. Overall, the protein functions as a negative regulator of myeloid cell proliferation and survival. Mutations in this gene are associated with defects and cancers of the immune system. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2014].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
inositol polyphosphate-5-phosphatase DMIM:601582Ensembl:ENSG00000168918HGNC:HGNC:6079PA298872q37.1

Gene Categories:

DRUGGABLE GENOME

GO terms in INPP5D


Term TypeEvidence TypeGO Term IDGO Des.
MFIEAGO:0004445inositol-polyphosphate 5-phosphatase activity
MFIPIGO:0005515protein binding
MFTASGO:0016314phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity
MFIEAGO:0017124SH3 domain binding
MFTASGO:0034485phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity
MFIEAGO:0051425PTB domain binding
MFTASGO:0052659inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity
BPTASGO:0006661phosphatidylinositol biosynthetic process
BPTASGO:0006796phosphate-containing compound metabolic process
BPIEAGO:0006915apoptotic process
BPTASGO:0007165signal transduction
BPIEAGO:0008340determination of adult lifespan
BPIEAGO:0009968negative regulation of signal transduction
BPIEAGO:0016064immunoglobulin mediated immune response
BPTASGO:0019221cytokine-mediated signaling pathway
BPIEAGO:0030889negative regulation of B cell proliferation
BPIEAGO:0035556intracellular signal transduction
BPIEAGO:0043065positive regulation of apoptotic process
BPTASGO:0043647inositol phosphate metabolic process
BPIEAGO:0045409negative regulation of interleukin-6 biosynthetic process
BPIEAGO:0045579positive regulation of B cell differentiation
BPIEAGO:0045648positive regulation of erythrocyte differentiation
BPIEAGO:0045656negative regulation of monocyte differentiation
BPIEAGO:0045659negative regulation of neutrophil differentiation
BPIEAGO:0045671negative regulation of osteoclast differentiation
BPIEAGO:0045779negative regulation of bone resorption
BPIEAGO:0046856phosphatidylinositol dephosphorylation
BPIEAGO:0050777negative regulation of immune response
BPTASGO:0050852T cell receptor signaling pathway
BPTASGO:0050900leukocyte migration
CCIDAGO:0005829cytosol
CCTASGO:0005829cytosol
CCIEAGO:0005856cytoskeleton
CCIEAGO:0005886plasma membrane
CCIEAGO:0045121membrane raft

Gene expression in normal tissue: INPP5D

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in INPP5D


DatabasePathway IDPathway Des.
reactomeR-HSA-109582Hemostasis
reactomeR-HSA-1280215Cytokine Signaling in Immune system
reactomeR-HSA-1280218Adaptive Immune System
reactomeR-HSA-1430728Metabolism
reactomeR-HSA-1483249Inositol phosphate metabolism
reactomeR-HSA-1483255PI Metabolism
reactomeR-HSA-1483257Phospholipid metabolism
reactomeR-HSA-1660499Synthesis of PIPs at the plasma membrane
reactomeR-HSA-168256Immune System
reactomeR-HSA-1855204Synthesis of IP3 and IP4 in the cytosol
reactomeR-HSA-202403TCR signaling
reactomeR-HSA-202424Downstream TCR signaling
reactomeR-HSA-202733Cell surface interactions at the vascular wall
reactomeR-HSA-210990PECAM1 interactions
reactomeR-HSA-449147Signaling by Interleukins
reactomeR-HSA-451927Interleukin-2 family signaling
reactomeR-HSA-512988Interleukin-3, Interleukin-5 and GM-CSF signaling
reactomeR-HSA-556833Metabolism of lipids
reactomeR-HSA-912526Interleukin receptor SHC signaling
netpathPathway_IL3IL3
netpathPathway_IL4IL4
netpathPathway_KitReceptorKitReceptor
netpathPathway_TCRTCR
pidbcr_5pathwayBCR signaling pathway
pidcxcr4_pathwayCXCR4-mediated signaling events
pidepopathwayEPO signaling pathway
pidfcer1pathwayFc-epsilon receptor I signaling in mast cells
pidgmcsf_pathwayGMCSF-mediated signaling events
pidil3_pathwayIL3-mediated signaling events
pidil4_2pathwayIL4-mediated signaling events
pidinsulin_pathwayInsulin Pathway
pidmet_pathwaySignaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
pidpi3kcipathwayClass I PI3K signaling events
pidtcr_pathwayTCR signaling in naïve CD4+ T cells
kegghsa00562Inositol phosphate metabolism - Homo sapiens (human)
kegghsa04070Phosphatidylinositol signaling system - Homo sapiens (human)
kegghsa04662B cell receptor signaling pathway - Homo sapiens (human)
kegghsa04664Fc epsilon RI signaling pathway - Homo sapiens (human)
kegghsa04666Fc gamma R-mediated phagocytosis - Homo sapiens (human)
humancycPWY-6358superpathway of D-myo-inositol (1,4,5)-trisphosphate metabolism
humancycPWY-63621D-myo-inositol hexakisphosphate biosynthesis II (mammalian)
humancycPWY-6364D-myo-inositol (1,3,4)-trisphosphate biosynthesis
humancycPWY-63683-phosphoinositide degradation
humancycPWY-6371superpathway of inositol phosphate compounds
smpdbSMP00358Fc Epsilon Receptor I Signaling in Mast Cells
smpdbSMP00463Phosphatidylinositol Phosphate Metabolism
smpdbSMP00582Joubert syndrome
wikipathwaysWP23B Cell Receptor Signaling Pathway
wikipathwaysWP286IL-3 Signaling Pathway
wikipathwaysWP304Kit receptor signaling pathway
wikipathwaysWP395IL-4 Signaling Pathway
wikipathwaysWP437EGF-EGFR Signaling Pathway

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD446LY 21832402
iGMDRD152179324-69-71
iGMDRD394BX-7951
iGMDRD466Chaetocin2
iGMDRD634SCHEMBL26080413
iGMDRD126Tipifarnib8
iGMDRD772BRD47702
iGMDRD599Salermide5
iGMDRD144NSC953972
iGMDRD781Sirolimus6
iGMDRD483SCH-5290746
iGMDRD399Selumetinib3
iGMDRD188Piperlongumine5
iGMDRD562Navitoclax3
iGMDRD506Fedratinib1
iGMDRD268Cerulenin2
iGMDRD138PX 122
iGMDRD255SB2250025
iGMDRD52Rotenone4
iGMDRD870BRD636103
iGMDRD318PAC-11
iGMDRD85Ursolic acid1
iGMDRD237ABT-7513
iGMDRD351GW843682X1
iGMDRD330BRD41322
iGMDRD512nutlin 33
iGMDRD116CD4372
iGMDRD523Cyanoquinoline, 112
iGMDRD871BRD63682
iGMDRD286Nsc 6328397
iGMDRD329Merck603
iGMDRD662JQ-12
iGMDRD147Prima-12
iGMDRD886Compound 1541A2
iGMDRD300Tozasertib3
iGMDRD137Indisulam3
iGMDRD121GMX17783
iGMDRD434BMS-5369243
iGMDRD705Nakiterpiosin3
iGMDRD289Parthenolide2
iGMDRD267Oligomycin A1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in INPP5D

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