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INPP5D

Summary: This gene is a member of the inositol polyphosphate-5-phosphatase (INPP5) family and encodes a protein with an N-terminal SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains. Expression of this protein is restricted to hematopoietic cells where its movement from the cytosol to the plasma membrane is mediated by tyrosine phosphorylation. At the plasma membrane, the protein hydrolyzes the 5' phosphate from phosphatidylinositol (3,4,5)-trisphosphate and inositol-1,3,4,5-tetrakisphosphate, thereby affecting multiple signaling pathways. The protein is also partly localized to the nucleus, where it may be involved in nuclear inositol phosphate signaling processes. Overall, the protein functions as a negative regulator of myeloid cell proliferation and survival. Mutations in this gene are associated with defects and cancers of the immune system. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2014].

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
inositol polyphosphate-5-phosphatase D	MIM:601582	Ensembl:ENSG00000168918	HGNC:HGNC:6079	PA29887	2q37.1

Gene Categories:

DRUGGABLE GENOME

GO terms in INPP5D

Term Type	Evidence Type	GO Term ID	GO Des.
MF	IEA	GO:0004445	inositol-polyphosphate 5-phosphatase activity
MF	IPI	GO:0005515	protein binding
MF	TAS	GO:0016314	phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity
MF	IEA	GO:0017124	SH3 domain binding
MF	TAS	GO:0034485	phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity
MF	IEA	GO:0051425	PTB domain binding
MF	TAS	GO:0052659	inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity
BP	TAS	GO:0006661	phosphatidylinositol biosynthetic process
BP	TAS	GO:0006796	phosphate-containing compound metabolic process
BP	IEA	GO:0006915	apoptotic process
BP	TAS	GO:0007165	signal transduction
BP	IEA	GO:0008340	determination of adult lifespan
BP	IEA	GO:0009968	negative regulation of signal transduction
BP	IEA	GO:0016064	immunoglobulin mediated immune response
BP	TAS	GO:0019221	cytokine-mediated signaling pathway
BP	IEA	GO:0030889	negative regulation of B cell proliferation
BP	IEA	GO:0035556	intracellular signal transduction
BP	IEA	GO:0043065	positive regulation of apoptotic process
BP	TAS	GO:0043647	inositol phosphate metabolic process
BP	IEA	GO:0045409	negative regulation of interleukin-6 biosynthetic process
BP	IEA	GO:0045579	positive regulation of B cell differentiation
BP	IEA	GO:0045648	positive regulation of erythrocyte differentiation
BP	IEA	GO:0045656	negative regulation of monocyte differentiation
BP	IEA	GO:0045659	negative regulation of neutrophil differentiation
BP	IEA	GO:0045671	negative regulation of osteoclast differentiation
BP	IEA	GO:0045779	negative regulation of bone resorption
BP	IEA	GO:0046856	phosphatidylinositol dephosphorylation
BP	IEA	GO:0050777	negative regulation of immune response
BP	TAS	GO:0050852	T cell receptor signaling pathway
BP	TAS	GO:0050900	leukocyte migration
CC	IDA	GO:0005829	cytosol
CC	TAS	GO:0005829	cytosol
CC	IEA	GO:0005856	cytoskeleton
CC	IEA	GO:0005886	plasma membrane
CC	IEA	GO:0045121	membrane raft

Gene expression in normal tissue: INPP5D

Select Project:

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in INPP5D

Database	Pathway ID	Pathway Des.
reactome	R-HSA-109582	Hemostasis
reactome	R-HSA-1280215	Cytokine Signaling in Immune system
reactome	R-HSA-1280218	Adaptive Immune System
reactome	R-HSA-1430728	Metabolism
reactome	R-HSA-1483249	Inositol phosphate metabolism
reactome	R-HSA-1483255	PI Metabolism
reactome	R-HSA-1483257	Phospholipid metabolism
reactome	R-HSA-1660499	Synthesis of PIPs at the plasma membrane
reactome	R-HSA-168256	Immune System
reactome	R-HSA-1855204	Synthesis of IP3 and IP4 in the cytosol
reactome	R-HSA-202403	TCR signaling
reactome	R-HSA-202424	Downstream TCR signaling
reactome	R-HSA-202733	Cell surface interactions at the vascular wall
reactome	R-HSA-210990	PECAM1 interactions
reactome	R-HSA-449147	Signaling by Interleukins
reactome	R-HSA-451927	Interleukin-2 family signaling
reactome	R-HSA-512988	Interleukin-3, Interleukin-5 and GM-CSF signaling
reactome	R-HSA-556833	Metabolism of lipids
reactome	R-HSA-912526	Interleukin receptor SHC signaling
netpath	Pathway_IL3	IL3
netpath	Pathway_IL4	IL4
netpath	Pathway_KitReceptor	KitReceptor
netpath	Pathway_TCR	TCR
pid	bcr_5pathway	BCR signaling pathway
pid	cxcr4_pathway	CXCR4-mediated signaling events
pid	epopathway	EPO signaling pathway
pid	fcer1pathway	Fc-epsilon receptor I signaling in mast cells
pid	gmcsf_pathway	GMCSF-mediated signaling events
pid	il3_pathway	IL3-mediated signaling events
pid	il4_2pathway	IL4-mediated signaling events
pid	insulin_pathway	Insulin Pathway
pid	met_pathway	Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
pid	pi3kcipathway	Class I PI3K signaling events
pid	tcr_pathway	TCR signaling in naïve CD4+ T cells
kegg	hsa00562	Inositol phosphate metabolism - Homo sapiens (human)
kegg	hsa04070	Phosphatidylinositol signaling system - Homo sapiens (human)
kegg	hsa04662	B cell receptor signaling pathway - Homo sapiens (human)
kegg	hsa04664	Fc epsilon RI signaling pathway - Homo sapiens (human)
kegg	hsa04666	Fc gamma R-mediated phagocytosis - Homo sapiens (human)
humancyc	PWY-6358	superpathway of D-myo-inositol (1,4,5)-trisphosphate metabolism
humancyc	PWY-6362	1D-myo-inositol hexakisphosphate biosynthesis II (mammalian)
humancyc	PWY-6364	D-myo-inositol (1,3,4)-trisphosphate biosynthesis
humancyc	PWY-6368	3-phosphoinositide degradation
humancyc	PWY-6371	superpathway of inositol phosphate compounds
smpdb	SMP00358	Fc Epsilon Receptor I Signaling in Mast Cells
smpdb	SMP00463	Phosphatidylinositol Phosphate Metabolism
smpdb	SMP00582	Joubert syndrome
wikipathways	WP23	B Cell Receptor Signaling Pathway
wikipathways	WP286	IL-3 Signaling Pathway
wikipathways	WP304	Kit receptor signaling pathway
wikipathways	WP395	IL-4 Signaling Pathway
wikipathways	WP437	EGF-EGFR Signaling Pathway

Gene-Drug: Aster Plot

Drug ID	Drug Name	Model Num.
iGMDRD446	LY 2183240	2
iGMDRD152	179324-69-7	1
iGMDRD394	BX-795	1
iGMDRD466	Chaetocin	2
iGMDRD634	SCHEMBL2608041	3
iGMDRD126	Tipifarnib	8
iGMDRD772	BRD4770	2
iGMDRD599	Salermide	5
iGMDRD144	NSC95397	2
iGMDRD781	Sirolimus	6
iGMDRD483	SCH-529074	6
iGMDRD399	Selumetinib	3
iGMDRD188	Piperlongumine	5
iGMDRD562	Navitoclax	3
iGMDRD506	Fedratinib	1
iGMDRD268	Cerulenin	2
iGMDRD138	PX 12	2
iGMDRD255	SB225002	5
iGMDRD52	Rotenone	4
iGMDRD870	BRD63610	3
iGMDRD318	PAC-1	1
iGMDRD85	Ursolic acid	1
iGMDRD237	ABT-751	3
iGMDRD351	GW843682X	1
iGMDRD330	BRD4132	2
iGMDRD512	nutlin 3	3
iGMDRD116	CD437	2
iGMDRD523	Cyanoquinoline, 11	2
iGMDRD871	BRD6368	2
iGMDRD286	Nsc 632839	7
iGMDRD329	Merck60	3
iGMDRD662	JQ-1	2
iGMDRD147	Prima-1	2
iGMDRD886	Compound 1541A	2
iGMDRD300	Tozasertib	3
iGMDRD137	Indisulam	3
iGMDRD121	GMX1778	3
iGMDRD434	BMS-536924	3
iGMDRD705	Nakiterpiosin	3
iGMDRD289	Parthenolide	2
iGMDRD267	Oligomycin A	1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in INPP5D

SITE

DATATYPES

CLASSFICATION

Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.