CDKL3
Summary: The protein encoded by this gene is a member of cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This gene was identified as a gene absent in leukemic patients with chromosome 5q deletion. This loss may be an important determinant of dysmyelopoiesis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| cyclin dependent kinase like 3 | MIM:608459 | Ensembl:ENSG00000006837 | HGNC:HGNC:15483 | PA26319 | 5q31.1 |
GO terms in CDKL3
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | TAS | GO:0004672 | protein kinase activity |
| MF | IBA | GO:0004693 | cyclin-dependent protein serine/threonine kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| CC | IBA | GO:0005634 | nucleus |
| CC | IEA | GO:0005737 | cytoplasm |
| BP | TAS | GO:0006464 | cellular protein modification process |
| BP | IBA | GO:0006468 | protein phosphorylation |
| BP | IEA | GO:0006468 | protein phosphorylation |
| BP | IBA | GO:0030517 | negative regulation of axon extension |
| BP | IBA | GO:0050775 | positive regulation of dendrite morphogenesis |
| BP | IEA | GO:0051726 | regulation of cell cycle |
| BP | IBA | GO:0097484 | dendrite extension |
Gene expression in normal tissue: CDKL3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CDKL3
| Database | Pathway ID | Pathway Des. |
|---|
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD705 | Nakiterpiosin | 3 |
| iGMDRD105 | Triptolide | 3 |
| iGMDRD289 | Parthenolide | 2 |
| iGMDRD121 | GMX1778 | 3 |
| iGMDRD271 | Brefeldin A | 3 |
| iGMDRD202 | Curcumin | 3 |
| iGMDRD246 | NPC26 | 3 |
| iGMDRD322 | FK 866 | 2 |
| iGMDRD662 | JQ-1 | 2 |
| iGMDRD366 | PI-103 | 1 |
| iGMDRD150 | RITA | 3 |
| iGMDRD523 | Cyanoquinoline, 11 | 4 |
| iGMDRD945 | ML214 | 2 |
| iGMDRD870 | BRD63610 | 2 |
| iGMDRD187 | BRD9876 | 3 |
| iGMDRD513 | BML-259 | 2 |
| iGMDRD138 | PX 12 | 2 |
| iGMDRD64 | Parbendazole | 2 |
| iGMDRD356 | PNU-74654 | 2 |
| iGMDRD100 | Zebularine | 2 |
| iGMDRD399 | Selumetinib | 2 |
| iGMDRD888 | Compound 44 | 2 |
| iGMDRD780 | PP-30 | 1 |
| iGMDRD398 | Sepantronium | 3 |
| iGMDRD562 | Navitoclax | 2 |
| iGMDRD433 | Lexibulin | 2 |
| iGMDRD420 | Leucascandrolide A | 2 |
| iGMDRD772 | BRD4770 | 2 |
| iGMDRD297 | Austocystin D | 2 |
| iGMDRD679 | Bistramide A | 3 |
| iGMDRD280 | CYTOCHALASIN B | 2 |
| iGMDRD446 | LY 2183240 | 3 |
| iGMDRD201 | SKI II | 2 |
| iGMDRD61 | Kinetin riboside | 5 |
| iGMDRD193 | Fqi1 | 4 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CDKL3
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