COQ8B


Summary: This gene encodes a protein with two copies of a domain found in protein kinases. The encoded protein has a complete protein kinase catalytic domain, and a truncated domain that contains only the active and binding sites of the protein kinase domain, however, it is not known whether the protein has any kinase activity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
coenzyme Q8BMIM:615567Ensembl:ENSG00000123815HGNC:HGNC:19041PA13498897419q13.2

Gene Categories:

DRUGGABLE GENOME

GO terms in COQ8B


Term TypeEvidence TypeGO Term IDGO Des.
MFIDAGO:0004672protein kinase activity
MFIEAGO:0005524ATP binding
MFIBAGO:0016301kinase activity
CCIBAGO:0005739mitochondrion
CCIDAGO:0005739mitochondrion
CCIEAGO:0005829cytosol
CCIEAGO:0005886plasma membrane
CCIEAGO:0016021integral component of membrane
CCIBAGO:0031314extrinsic component of mitochondrial inner membrane
CCIEAGO:0031966mitochondrial membrane
BPIDAGO:0006468protein phosphorylation
BPIBAGO:0006744ubiquinone biosynthetic process
BPIMPGO:0006744ubiquinone biosynthetic process
BPIMPGO:0021692cerebellar Purkinje cell layer morphogenesis

Gene expression in normal tissue: COQ8B

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in COQ8B


DatabasePathway IDPathway Des.

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD420Leucascandrolide A1
iGMDRD387CHIR-990212
iGMDRD144NSC953975
iGMDRD116CD4373
iGMDRD79Gemcitabine5
iGMDRD781Sirolimus2
iGMDRD446LY 21832403
iGMDRD152179324-69-74
iGMDRD61Kinetin riboside3
iGMDRD57Chloropentafluorobenzene2
iGMDRD297Austocystin D5
iGMDRD251ML1622
iGMDRD138PX 121
iGMDRD121GMX17782
iGMDRD103SN-384
iGMDRD255SB2250024
iGMDRD231Importazole2
iGMDRD870BRD636103
iGMDRD399Selumetinib2
iGMDRD414MST-3125
iGMDRD286Nsc 6328395
iGMDRD188Piperlongumine7
iGMDRD263AACOCF31
iGMDRD886Compound 1541A2
iGMDRD300Tozasertib1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in COQ8B

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