COQ8B
Summary: This gene encodes a protein with two copies of a domain found in protein kinases. The encoded protein has a complete protein kinase catalytic domain, and a truncated domain that contains only the active and binding sites of the protein kinase domain, however, it is not known whether the protein has any kinase activity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| coenzyme Q8B | MIM:615567 | Ensembl:ENSG00000123815 | HGNC:HGNC:19041 | PA134988974 | 19q13.2 |
Gene Categories:
DRUGGABLE GENOMEGO terms in COQ8B
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IDA | GO:0004672 | protein kinase activity |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IBA | GO:0016301 | kinase activity |
| CC | IBA | GO:0005739 | mitochondrion |
| CC | IDA | GO:0005739 | mitochondrion |
| CC | IEA | GO:0005829 | cytosol |
| CC | IEA | GO:0005886 | plasma membrane |
| CC | IEA | GO:0016021 | integral component of membrane |
| CC | IBA | GO:0031314 | extrinsic component of mitochondrial inner membrane |
| CC | IEA | GO:0031966 | mitochondrial membrane |
| BP | IDA | GO:0006468 | protein phosphorylation |
| BP | IBA | GO:0006744 | ubiquinone biosynthetic process |
| BP | IMP | GO:0006744 | ubiquinone biosynthetic process |
| BP | IMP | GO:0021692 | cerebellar Purkinje cell layer morphogenesis |
Gene expression in normal tissue: COQ8B
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in COQ8B
| Database | Pathway ID | Pathway Des. |
|---|
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD420 | Leucascandrolide A | 1 |
| iGMDRD387 | CHIR-99021 | 2 |
| iGMDRD144 | NSC95397 | 5 |
| iGMDRD116 | CD437 | 3 |
| iGMDRD79 | Gemcitabine | 5 |
| iGMDRD781 | Sirolimus | 2 |
| iGMDRD446 | LY 2183240 | 3 |
| iGMDRD152 | 179324-69-7 | 4 |
| iGMDRD61 | Kinetin riboside | 3 |
| iGMDRD57 | Chloropentafluorobenzene | 2 |
| iGMDRD297 | Austocystin D | 5 |
| iGMDRD251 | ML162 | 2 |
| iGMDRD138 | PX 12 | 1 |
| iGMDRD121 | GMX1778 | 2 |
| iGMDRD103 | SN-38 | 4 |
| iGMDRD255 | SB225002 | 4 |
| iGMDRD231 | Importazole | 2 |
| iGMDRD870 | BRD63610 | 3 |
| iGMDRD399 | Selumetinib | 2 |
| iGMDRD414 | MST-312 | 5 |
| iGMDRD286 | Nsc 632839 | 5 |
| iGMDRD188 | Piperlongumine | 7 |
| iGMDRD263 | AACOCF3 | 1 |
| iGMDRD886 | Compound 1541A | 2 |
| iGMDRD300 | Tozasertib | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in COQ8B
CLASSFICATION
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