DICER1
Summary: This gene encodes a protein possessing an RNA helicase motif containing a DEXH box in its amino terminus and an RNA motif in the carboxy terminus. The encoded protein functions as a ribonuclease and is required by the RNA interference and small temporal RNA (stRNA) pathways to produce the active small RNA component that represses gene expression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2010].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| dicer 1, ribonuclease III | MIM:606241 | Ensembl:ENSG00000100697 | HGNC:HGNC:17098 | PA38437 | 14q32.13 |
Gene Categories:
CLINICALLY ACTIONABLEGO terms in DICER1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0003677 | DNA binding |
| MF | IBA | GO:0003723 | RNA binding |
| MF | IDA | GO:0003725 | double-stranded RNA binding |
| MF | IMP | GO:0003725 | double-stranded RNA binding |
| MF | IEA | GO:0004386 | helicase activity |
| MF | IDA | GO:0004521 | endoribonuclease activity |
| MF | IMP | GO:0004521 | endoribonuclease activity |
| MF | TAS | GO:0004521 | endoribonuclease activity |
| MF | EXP | GO:0004525 | ribonuclease III activity |
| MF | IBA | GO:0004525 | ribonuclease III activity |
| MF | IDA | GO:0004525 | ribonuclease III activity |
| MF | IBA | GO:0004530 | deoxyribonuclease I activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IPI | GO:0019904 | protein domain specific binding |
| MF | IDA | GO:0035197 | siRNA binding |
| MF | IEA | GO:0046872 | metal ion binding |
| MF | IDA | GO:0070883 | pre-miRNA binding |
| MF | IDA | GO:0070883 | pre-miRNA binding |
| CC | IBA | GO:0005634 | nucleus |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IEA | GO:0005793 | endoplasmic reticulum-Golgi intermediate compartment |
| CC | TAS | GO:0005829 | cytosol |
| CC | IBA | GO:0016442 | RISC complex |
| CC | IDA | GO:0016442 | RISC complex |
| CC | IEA | GO:0030425 | dendrite |
| CC | IEA | GO:0030426 | growth cone |
| CC | IC | GO:0033167 | ARC complex |
| CC | IDA | GO:0035068 | micro-ribonucleoprotein complex |
| CC | IDA | GO:0070062 | extracellular exosome |
| CC | IDA | GO:0070578 | RISC-loading complex |
| BP | ISS | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | IBA | GO:0006309 | apoptotic DNA fragmentation |
| BP | TAS | GO:0010586 | miRNA metabolic process |
| BP | ISS | GO:0010626 | negative regulation of Schwann cell proliferation |
| BP | ISS | GO:0014040 | positive regulation of Schwann cell differentiation |
| BP | ISS | GO:0021675 | nerve development |
| BP | IBA | GO:0030422 | production of siRNA involved in RNA interference |
| BP | IDA | GO:0030422 | production of siRNA involved in RNA interference |
| BP | TAS | GO:0030422 | production of siRNA involved in RNA interference |
| BP | IMP | GO:0030423 | targeting of mRNA for destruction involved in RNA interference |
| BP | IBA | GO:0031054 | pre-miRNA processing |
| BP | IDA | GO:0031054 | pre-miRNA processing |
| BP | ISS | GO:0031643 | positive regulation of myelination |
| BP | ISS | GO:0032290 | peripheral nervous system myelin formation |
| BP | IMP | GO:0033168 | conversion of ds siRNA to ss siRNA involved in RNA interference |
| BP | IDA | GO:0035087 | siRNA loading onto RISC involved in RNA interference |
| BP | IDA | GO:0035196 | production of miRNAs involved in gene silencing by miRNA |
| BP | ISS | GO:0035196 | production of miRNAs involved in gene silencing by miRNA |
| BP | IDA | GO:0035280 | miRNA loading onto RISC involved in gene silencing by miRNA |
| BP | IMP | GO:0036404 | conversion of ds siRNA to ss siRNA |
| BP | ISS | GO:0048812 | neuron projection morphogenesis |
| BP | IBA | GO:0090501 | RNA phosphodiester bond hydrolysis |
| BP | IDA | GO:0090502 | RNA phosphodiester bond hydrolysis, endonucleolytic |
Gene expression in normal tissue: DICER1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in DICER1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| pid | tap63pathway | Validated transcriptional targets of TAp63 isoforms |
| kegg | hsa05206 | MicroRNAs in cancer - Homo sapiens (human) |
| wikipathways | WP2338 | miRNA Biogenesis |
| wikipathways | WP2805 | RNA interference |
| wikipathways | WP2943 | Hypoxia-mediated EMT and Stemness |
| wikipathways | WP411 | mRNA Processing |
| reactome | R-HSA-203927 | MicroRNA (miRNA) biogenesis |
| reactome | R-HSA-211000 | Gene Silencing by RNA |
| reactome | R-HSA-426486 | Small interfering RNA (siRNA) biogenesis |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| biocarta | dicerpathway | dicer pathway |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD434 | BMS-536924 | 2 |
| iGMDRD705 | Nakiterpiosin | 2 |
| iGMDRD105 | Triptolide | 2 |
| iGMDRD77 | Itraconazole | 2 |
| iGMDRD202 | Curcumin | 2 |
| iGMDRD121 | GMX1778 | 1 |
| iGMDRD103 | SN-38 | 3 |
| iGMDRD263 | AACOCF3 | 1 |
| iGMDRD505 | Pevonedistat | 5 |
| iGMDRD322 | FK 866 | 3 |
| iGMDRD882 | CIL41 | 2 |
| iGMDRD414 | MST-312 | 2 |
| iGMDRD286 | Nsc 632839 | 4 |
| iGMDRD424 | Tamatinib | 2 |
| iGMDRD150 | RITA | 3 |
| iGMDRD560 | MK-2206 | 2 |
| iGMDRD405 | PIK-75 | 1 |
| iGMDRD123 | Isoevodiamine | 3 |
| iGMDRD901 | ELCPK | 2 |
| iGMDRD211 | (1S,3R)-RSL3 | 3 |
| iGMDRD341 | Triacsin c | 1 |
| iGMDRD698 | Neratinib | 6 |
| iGMDRD351 | GW843682X | 4 |
| iGMDRD138 | PX 12 | 5 |
| iGMDRD64 | Parbendazole | 2 |
| iGMDRD100 | Zebularine | 3 |
| iGMDRD780 | PP-30 | 3 |
| iGMDRD577 | BIX01294 | 3 |
| iGMDRD328 | AR-42 | 1 |
| iGMDRD670 | ML 210 | 3 |
| iGMDRD126 | Tipifarnib | 8 |
| iGMDRD420 | Leucascandrolide A | 1 |
| iGMDRD679 | Bistramide A | 1 |
| iGMDRD446 | LY 2183240 | 1 |
| iGMDRD152 | 179324-69-7 | 3 |
| iGMDRD193 | Fqi1 | 1 |
| iGMDRD61 | Kinetin riboside | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in DICER1
CLASSFICATION
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