DICER1

Summary: This gene encodes a protein possessing an RNA helicase motif containing a DEXH box in its amino terminus and an RNA motif in the carboxy terminus. The encoded protein functions as a ribonuclease and is required by the RNA interference and small temporal RNA (stRNA) pathways to produce the active small RNA component that represses gene expression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2010].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Namedicer 1, ribonuclease III
OMIM IDMIM:606241
Ensembl IDEnsembl:ENSG00000100697
HGNC IDHGNC:HGNC:17098
PHARMGKB IDPA38437
Map Location14q32.13

Gene Categories:

CLINICALLY ACTIONABLE

GO terms in DICER1


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IEA GO:0003677 DNA binding
MF IBA GO:0003723 RNA binding
MF IDA GO:0003725 double-stranded RNA binding
MF IMP GO:0003725 double-stranded RNA binding
MF IEA GO:0004386 helicase activity
MF IDA GO:0004521 endoribonuclease activity
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Gene expression in normal tissue: DICER1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

undefined29Cell cycle1Chromatin histone acetylation1Proteasome1Ferroptosis1PI3K/MTOR signaling1Stilbenoid, diarylheptanoid and gingerol biosynthesis1DNA replication1Metabolism1

Pathways in DICER1


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Database
Pathway ID
Pathway Des.
pid tap63pathway Validated transcriptional targets of TAp63 isoforms
kegg hsa05206 MicroRNAs in cancer - Homo sapiens (human)
wikipathways WP2338 miRNA Biogenesis
wikipathways WP2805 RNA interference
wikipathways WP2943 Hypoxia-mediated EMT and Stemness
wikipathways WP411 mRNA Processing
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD434 BMS-536924 2
iGMDRD705 Nakiterpiosin 2
iGMDRD105 Triptolide 2
iGMDRD77 Itraconazole 2
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in DICER1

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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