AFDN
Summary: This gene encodes a multi-domain protein involved in signaling and organization of cell junctions during embryogenesis. It has also been identified as the fusion partner of acute lymphoblastic leukemia (ALL-1) gene, involved in acute myeloid leukemias with t(6;11)(q27;q23) translocation. Alternatively spliced transcript variants encoding different isoforms have been described for this gene, however, not all have been fully characterized.[provided by RefSeq, May 2011].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
OMIM IDMIM:159559 Ensembl IDEnsembl:ENSG00000130396 HGNC IDHGNC:HGNC:7137 PHARMGKB IDPA30853 Map Location6q27 |
GO terms in AFDN
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Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
MF | IPI | GO:0005515 | protein binding |
MF | TAS | GO:0008022 | protein C-terminus binding |
MF | IDA | GO:0017016 | Ras GTPase binding |
MF | HDA | GO:0045296 | cadherin binding |
MF | IBA | GO:0050839 | cell adhesion molecule binding |
CC | IDA | GO:0005654 | nucleoplasm |
Gene expression in normal tissue: AFDN
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in AFDN
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Database | Pathway ID | Pathway Des. |
---|---|---|
reactome | R-HSA-1500931 | Cell-Cell communication |
reactome | R-HSA-1500931 | Cell-Cell communication |
reactome | R-HSA-418990 | Adherens junctions interactions |
reactome | R-HSA-418990 | Adherens junctions interactions |
reactome | R-HSA-421270 | Cell-cell junction organization |
reactome | R-HSA-421270 | Cell-cell junction organization |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot

Gene-drug targets distribution
Gene Structure: PDB
Models in AFDN
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
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No matching records found |