AFDN
Summary: This gene encodes a multi-domain protein involved in signaling and organization of cell junctions during embryogenesis. It has also been identified as the fusion partner of acute lymphoblastic leukemia (ALL-1) gene, involved in acute myeloid leukemias with t(6;11)(q27;q23) translocation. Alternatively spliced transcript variants encoding different isoforms have been described for this gene, however, not all have been fully characterized.[provided by RefSeq, May 2011].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| afadin, adherens junction formation factor | MIM:159559 | Ensembl:ENSG00000130396 | HGNC:HGNC:7137 | PA30853 | 6q27 |
GO terms in AFDN
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IPI | GO:0005515 | protein binding |
| MF | TAS | GO:0008022 | protein C-terminus binding |
| MF | IDA | GO:0017016 | Ras GTPase binding |
| MF | HDA | GO:0045296 | cadherin binding |
| MF | IBA | GO:0050839 | cell adhesion molecule binding |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005911 | cell-cell junction |
| CC | IBA | GO:0005913 | cell-cell adherens junction |
| CC | IDA | GO:0016607 | nuclear speck |
| CC | IDA | GO:0030054 | cell junction |
| BP | IEA | GO:0007155 | cell adhesion |
| BP | IEA | GO:0007165 | signal transduction |
| BP | TAS | GO:0007267 | cell-cell signaling |
| BP | IBA | GO:0032880 | regulation of protein localization |
| BP | TAS | GO:0034332 | adherens junction organization |
| BP | IMP | GO:0043547 | positive regulation of GTPase activity |
| BP | IMP | GO:0090557 | establishment of endothelial intestinal barrier |
Gene expression in normal tissue: AFDN
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in AFDN
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1500931 | Cell-Cell communication |
| reactome | R-HSA-1500931 | Cell-Cell communication |
| reactome | R-HSA-418990 | Adherens junctions interactions |
| reactome | R-HSA-418990 | Adherens junctions interactions |
| reactome | R-HSA-421270 | Cell-cell junction organization |
| reactome | R-HSA-421270 | Cell-cell junction organization |
| reactome | R-HSA-446728 | Cell junction organization |
| reactome | R-HSA-446728 | Cell junction organization |
| wikipathways | WP3888 | VEGFA-VEGFR2 Signaling Pathway |
| wikipathways | WP4223 | Ras Signaling |
| kegg | hsa04014 | Ras signaling pathway - Homo sapiens (human) |
| kegg | hsa04015 | Rap1 signaling pathway - Homo sapiens (human) |
| kegg | hsa04024 | cAMP signaling pathway - Homo sapiens (human) |
| kegg | hsa04520 | Adherens junction - Homo sapiens (human) |
| kegg | hsa04530 | Tight junction - Homo sapiens (human) |
| kegg | hsa04670 | Leukocyte transendothelial migration - Homo sapiens (human) |
| pid | ecadherin_nascentaj_pathway | E-cadherin signaling in the nascent adherens junction |
| pid | ecadherin_stabilization_pathway | Stabilization and expansion of the E-cadherin adherens junction |
| pid | nectin_pathway | Nectin adhesion pathway |
| pid | pdgfrbpathway | PDGFR-beta signaling pathway |
| pid | shp2_pathway | SHP2 signaling |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD446 | LY 2183240 | 2 |
| iGMDRD152 | 179324-69-7 | 3 |
| iGMDRD61 | Kinetin riboside | 3 |
| iGMDRD193 | Fqi1 | 5 |
| iGMDRD394 | BX-795 | 1 |
| iGMDRD466 | Chaetocin | 3 |
| iGMDRD634 | SCHEMBL2608041 | 3 |
| iGMDRD126 | Tipifarnib | 2 |
| iGMDRD433 | Lexibulin | 2 |
| iGMDRD151 | CHM-1 | 5 |
| iGMDRD889 | Compound 7d-cis | 3 |
| iGMDRD1008 | SR-II-138A | 2 |
| iGMDRD772 | BRD4770 | 1 |
| iGMDRD420 | Leucascandrolide A | 6 |
| iGMDRD427 | ABT737 | 3 |
| iGMDRD144 | NSC95397 | 2 |
| iGMDRD494 | Neopeltolide | 3 |
| iGMDRD462 | OSI-906 (Linsitinib) | 1 |
| iGMDRD781 | Sirolimus | 4 |
| iGMDRD100 | Zebularine | 3 |
| iGMDRD188 | Piperlongumine | 5 |
| iGMDRD399 | Selumetinib | 3 |
| iGMDRD887 | Compound 23 citrate | 2 |
| iGMDRD506 | Fedratinib | 2 |
| iGMDRD577 | BIX01294 | 11 |
| iGMDRD562 | Navitoclax | 6 |
| iGMDRD64 | Parbendazole | 5 |
| iGMDRD60 | Quinoclamine | 2 |
| iGMDRD23 | Gossypol | 6 |
| iGMDRD451 | Serdemetan | 1 |
| iGMDRD138 | PX 12 | 3 |
| iGMDRD260 | FQI-2 | 1 |
| iGMDRD255 | SB225002 | 4 |
| iGMDRD171 | Pemetrexed | 4 |
| iGMDRD441 | TW 37 | 4 |
| iGMDRD341 | Triacsin c | 7 |
| iGMDRD351 | GW843682X | 1 |
| iGMDRD314 | Tanespimycin | 2 |
| iGMDRD237 | ABT-751 | 1 |
| iGMDRD123 | Isoevodiamine | 4 |
| iGMDRD605 | AZD6482 | 1 |
| iGMDRD945 | ML214 | 3 |
| iGMDRD607 | Ubistatin B | 3 |
| iGMDRD116 | CD437 | 4 |
| iGMDRD560 | MK-2206 | 1 |
| iGMDRD150 | RITA | 6 |
| iGMDRD286 | Nsc 632839 | 3 |
| iGMDRD662 | JQ-1 | 2 |
| iGMDRD366 | PI-103 | 3 |
| iGMDRD505 | Pevonedistat | 5 |
| iGMDRD263 | AACOCF3 | 2 |
| iGMDRD552 | AZD-1775 | 2 |
| iGMDRD246 | NPC26 | 4 |
| iGMDRD103 | SN-38 | 4 |
| iGMDRD137 | Indisulam | 2 |
| iGMDRD158 | NSC141540 | 3 |
| iGMDRD289 | Parthenolide | 6 |
| iGMDRD705 | Nakiterpiosin | 2 |
| iGMDRD434 | BMS-536924 | 1 |
| iGMDRD77 | Itraconazole | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in AFDN
CLASSFICATION
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