AFDN


Summary: This gene encodes a multi-domain protein involved in signaling and organization of cell junctions during embryogenesis. It has also been identified as the fusion partner of acute lymphoblastic leukemia (ALL-1) gene, involved in acute myeloid leukemias with t(6;11)(q27;q23) translocation. Alternatively spliced transcript variants encoding different isoforms have been described for this gene, however, not all have been fully characterized.[provided by RefSeq, May 2011].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location

GO terms in AFDN


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IPI GO:0005515 protein binding
MF TAS GO:0008022 protein C-terminus binding
MF IDA GO:0017016 Ras GTPase binding
MF HDA GO:0045296 cadherin binding
MF IBA GO:0050839 cell adhesion molecule binding
CC IDA GO:0005654 nucleoplasm
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Gene expression in normal tissue: AFDN

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

undefined41PI3K/MTOR signaling3Apoptosis regulation2DNA replication2Cell cycle1Chromatin histone acetylation1Protein stability and degradation1Chromatin other1One carbon pool by folate1Biosynthesis of secondary metabolites1

Pathways in AFDN


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Database
Pathway ID
Pathway Des.
reactome R-HSA-1500931 Cell-Cell communication
reactome R-HSA-1500931 Cell-Cell communication
reactome R-HSA-418990 Adherens junctions interactions
reactome R-HSA-418990 Adherens junctions interactions
reactome R-HSA-421270 Cell-cell junction organization
reactome R-HSA-421270 Cell-cell junction organization
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD446 LY 2183240 2
iGMDRD152 179324-69-7 3
iGMDRD61 Kinetin riboside 3
iGMDRD193 Fqi1 5
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in AFDN

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
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