HECW1
Summary:
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1 | MIM:610384 | Ensembl:ENSG00000002746 | HGNC:HGNC:22195 | PA134964191 | 7p14.1-p13 |
GO terms in HECW1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| BP | IBA | GO:0000209 | protein polyubiquitination |
| BP | IBA | GO:0016567 | protein ubiquitination |
| BP | IEA | GO:0016567 | protein ubiquitination |
| BP | IBA | GO:0043161 | proteasome-mediated ubiquitin-dependent protein catabolic process |
| BP | IBA | GO:0045732 | positive regulation of protein catabolic process |
| BP | IBA | GO:0048814 | regulation of dendrite morphogenesis |
| BP | TAS | GO:0090090 | negative regulation of canonical Wnt signaling pathway |
| BP | IBA | GO:2000650 | negative regulation of sodium ion transmembrane transporter activity |
| MF | IBA | GO:0061630 | ubiquitin protein ligase activity |
| MF | TAS | GO:0061630 | ubiquitin protein ligase activity |
Gene expression in normal tissue: HECW1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in HECW1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-195721 | Signaling by WNT |
| reactome | R-HSA-201681 | TCF dependent signaling in response to WNT |
| reactome | R-HSA-4641258 | Degradation of DVL |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD152 | 179324-69-7 | 5 |
| iGMDRD394 | BX-795 | 3 |
| iGMDRD297 | Austocystin D | 3 |
| iGMDRD420 | Leucascandrolide A | 1 |
| iGMDRD387 | CHIR-99021 | 1 |
| iGMDRD210 | AC55649 | 1 |
| iGMDRD433 | Lexibulin | 3 |
| iGMDRD76 | Simvastatin | 3 |
| iGMDRD670 | ML 210 | 8 |
| iGMDRD780 | PP-30 | 6 |
| iGMDRD562 | Navitoclax | 6 |
| iGMDRD23 | Gossypol | 3 |
| iGMDRD874 | BRD8958 | 2 |
| iGMDRD60 | Quinoclamine | 3 |
| iGMDRD64 | Parbendazole | 1 |
| iGMDRD613 | CHEMBL258148 | 1 |
| iGMDRD309 | 17AAG | 1 |
| iGMDRD782 | DC-45-A2 | 3 |
| iGMDRD698 | Neratinib | 5 |
| iGMDRD351 | GW843682X | 2 |
| iGMDRD945 | ML214 | 1 |
| iGMDRD154 | NSC23766 | 3 |
| iGMDRD177 | Teniposide | 3 |
| iGMDRD123 | Isoevodiamine | 3 |
| iGMDRD211 | (1S,3R)-RSL3 | 6 |
| iGMDRD84 | Lovastatin acid | 3 |
| iGMDRD116 | CD437 | 1 |
| iGMDRD329 | Merck60 | 3 |
| iGMDRD414 | MST-312 | 3 |
| iGMDRD147 | Prima-1 | 3 |
| iGMDRD552 | AZD-1775 | 1 |
| iGMDRD505 | Pevonedistat | 3 |
| iGMDRD158 | NSC141540 | 3 |
| iGMDRD251 | ML162 | 3 |
| iGMDRD103 | SN-38 | 3 |
| iGMDRD434 | BMS-536924 | 8 |
| iGMDRD192 | CIL56 | 3 |
| iGMDRD705 | Nakiterpiosin | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in HECW1
CLASSFICATION
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