BAG6
Summary: This gene was first characterized as part of a cluster of genes located within the human major histocompatibility complex class III region. This gene encodes a nuclear protein that is cleaved by caspase 3 and is implicated in the control of apoptosis. In addition, the protein forms a complex with E1A binding protein p300 and is required for the acetylation of p53 in response to DNA damage. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| BCL2 associated athanogene 6 | MIM:142590 | Ensembl:ENSG00000204463 | HGNC:HGNC:13919 | PA25264 | 6p21.33 |
GO terms in BAG6
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IPI | GO:0005102 | signaling receptor binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0030544 | Hsp70 protein binding |
| MF | ISS | GO:0031593 | polyubiquitin modification-dependent protein binding |
| MF | IPI | GO:0031625 | ubiquitin protein ligase binding |
| MF | IDA | GO:0043022 | ribosome binding |
| MF | IDA | GO:0051787 | misfolded protein binding |
| MF | ISS | GO:0070628 | proteasome binding |
| MF | IPI | GO:1990381 | ubiquitin-specific protease binding |
| BP | ISS | GO:0001822 | kidney development |
| BP | IDA | GO:0002429 | immune response-activating cell surface receptor signaling pathway |
| BP | IEA | GO:0006325 | chromatin organization |
| BP | ISS | GO:0006511 | ubiquitin-dependent protein catabolic process |
| BP | IDA | GO:0006915 | apoptotic process |
| BP | ISS | GO:0007130 | synaptonemal complex assembly |
| BP | ISS | GO:0007283 | spermatogenesis |
| BP | ISS | GO:0007420 | brain development |
| BP | IMP | GO:0010498 | proteasomal protein catabolic process |
| BP | IDA | GO:0018393 | internal peptidyl-lysine acetylation |
| BP | IDA | GO:0030101 | natural killer cell activation |
| BP | IEA | GO:0030154 | cell differentiation |
| BP | ISS | GO:0030324 | lung development |
| BP | IDA | GO:0030433 | ubiquitin-dependent ERAD pathway |
| BP | IMP | GO:0030433 | ubiquitin-dependent ERAD pathway |
| BP | ISS | GO:0032435 | negative regulation of proteasomal ubiquitin-dependent protein catabolic process |
| BP | IEA | GO:0042127 | regulation of cell proliferation |
| BP | IMP | GO:0042771 | intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator |
| BP | IEA | GO:0043066 | negative regulation of apoptotic process |
| BP | ISS | GO:0045861 | negative regulation of proteolysis |
| BP | ISS | GO:0045995 | regulation of embryonic development |
| BP | ISS | GO:0050821 | protein stabilization |
| BP | IMP | GO:0061857 | endoplasmic reticulum stress-induced pre-emptive quality control |
| BP | ISS | GO:0070059 | intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress |
| BP | IDA | GO:0071712 | ER-associated misfolded protein catabolic process |
| BP | IDA | GO:0071816 | tail-anchored membrane protein insertion into ER membrane |
| BP | IMP | GO:1904294 | positive regulation of ERAD pathway |
| BP | IMP | GO:1904378 | maintenance of unfolded protein involved in ERAD pathway |
| BP | NAS | GO:1904379 | protein localization to cytosolic proteasome complex involved in ERAD pathway |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005829 | cytosol |
| CC | HDA | GO:0016020 | membrane |
| CC | IDA | GO:0016020 | membrane |
| CC | IDA | GO:0043231 | intracellular membrane-bounded organelle |
| CC | IDA | GO:0070062 | extracellular exosome |
| CC | IDA | GO:0071818 | BAT3 complex |
Gene expression in normal tissue: BAG6
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in BAG6
| Database | Pathway ID | Pathway Des. |
|---|
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD560 | MK-2206 | 1 |
| iGMDRD116 | CD437 | 3 |
| iGMDRD79 | Gemcitabine | 2 |
| iGMDRD177 | Teniposide | 3 |
| iGMDRD123 | Isoevodiamine | 2 |
| iGMDRD211 | (1S,3R)-RSL3 | 2 |
| iGMDRD945 | ML214 | 3 |
| iGMDRD57 | Chloropentafluorobenzene | 2 |
| iGMDRD351 | GW843682X | 4 |
| iGMDRD434 | BMS-536924 | 4 |
| iGMDRD705 | Nakiterpiosin | 3 |
| iGMDRD137 | Indisulam | 2 |
| iGMDRD121 | GMX1778 | 3 |
| iGMDRD158 | NSC141540 | 3 |
| iGMDRD103 | SN-38 | 3 |
| iGMDRD552 | AZD-1775 | 2 |
| iGMDRD42 | Vorinostat | 3 |
| iGMDRD872 | BRD7137 | 2 |
| iGMDRD286 | Nsc 632839 | 3 |
| iGMDRD414 | MST-312 | 2 |
| iGMDRD366 | PI-103 | 3 |
| iGMDRD329 | Merck60 | 5 |
| iGMDRD144 | NSC95397 | 2 |
| iGMDRD781 | Sirolimus | 8 |
| iGMDRD494 | Neopeltolide | 1 |
| iGMDRD151 | CHM-1 | 3 |
| iGMDRD126 | Tipifarnib | 5 |
| iGMDRD772 | BRD4770 | 2 |
| iGMDRD420 | Leucascandrolide A | 2 |
| iGMDRD61 | Kinetin riboside | 2 |
| iGMDRD639 | YK 4-279 | 2 |
| iGMDRD782 | DC-45-A2 | 1 |
| iGMDRD870 | BRD63610 | 2 |
| iGMDRD309 | 17AAG | 2 |
| iGMDRD226 | ML006 | 2 |
| iGMDRD318 | PAC-1 | 1 |
| iGMDRD260 | FQI-2 | 2 |
| iGMDRD255 | SB225002 | 3 |
| iGMDRD690 | PRIMA-1MET | 2 |
| iGMDRD524 | ISX-9 | 1 |
| iGMDRD398 | Sepantronium | 3 |
| iGMDRD577 | BIX01294 | 2 |
| iGMDRD506 | Fedratinib | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in BAG6
CLASSFICATION
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