ADAMTS19

Summary: This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene has high sequence similarity to the protein encoded by ADAMTS16, another family member. [provided by RefSeq, Jul 2008].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
NameADAM metallopeptidase with thrombospondin type 1 motif 19
OMIM IDMIM:607513
Ensembl IDEnsembl:ENSG00000145808
HGNC IDHGNC:HGNC:17111
PHARMGKB IDPA24545
Map Location5q23.3

GO terms in ADAMTS19


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IEA GO:0004222 metalloendopeptidase activity
MF IEA GO:0046872 metal ion binding
BP IEA GO:0006508 proteolysis
CC IEA GO:0005576 extracellular region
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Gene expression in normal tissue: ADAMTS19

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 47undefinedtissue: undefined cancer: ADENOCARCINOMA model num: 16LUNtissue: LUN cancer: LUNG model num: 0LUNGtissue: LUNG cancer: undefined model num: 21BOWEtissue: BOWE cancer: BOWEL model num: 0BOWELtissue: BOWEL cancer: undefined model num: 7SKItissue: SKI cancer: SKIN model num: 0SKINtissue: SKIN cancer: undefined model num: 8

Gene-drug pathway distribution

undefined23DNA replication2Other, kinases1Biosynthesis of secondary metabolites1Apoptosis regulation1ERK MAPK signaling1Ferroptosis1Metabolism1Stilbenoid, diarylheptanoid and gingerol biosynthesis1PI3K/MTOR signaling1

Pathways in ADAMTS19


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Database
Pathway ID
Pathway Des.
reactome R-HSA-1643685 Disease
reactome R-HSA-3781865 Diseases of glycosylation
reactome R-HSA-3906995 Diseases associated with O-glycosylation of proteins
reactome R-HSA-392499 Metabolism of proteins
reactome R-HSA-5083635 Defective B3GALTL causes Peters-plus syndrome (PpS)
reactome R-HSA-5173105 O-linked glycosylation
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD505 Pevonedistat 3
iGMDRD147 Prima-1 1
iGMDRD322 FK 866 3
iGMDRD286 Nsc 632839 8
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ADAMTS19

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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