ADAMTS19
Summary: This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene has high sequence similarity to the protein encoded by ADAMTS16, another family member. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| ADAM metallopeptidase with thrombospondin type 1 motif 19 | MIM:607513 | Ensembl:ENSG00000145808 | HGNC:HGNC:17111 | PA24545 | 5q23.3 |
GO terms in ADAMTS19
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0004222 | metalloendopeptidase activity |
| MF | IEA | GO:0046872 | metal ion binding |
| BP | IEA | GO:0006508 | proteolysis |
| CC | IEA | GO:0005576 | extracellular region |
Gene expression in normal tissue: ADAMTS19
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ADAMTS19
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-3781865 | Diseases of glycosylation |
| reactome | R-HSA-3906995 | Diseases associated with O-glycosylation of proteins |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-5083635 | Defective B3GALTL causes Peters-plus syndrome (PpS) |
| reactome | R-HSA-5173105 | O-linked glycosylation |
| reactome | R-HSA-5173214 | O-glycosylation of TSR domain-containing proteins |
| reactome | R-HSA-597592 | Post-translational protein modification |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD505 | Pevonedistat | 3 |
| iGMDRD147 | Prima-1 | 1 |
| iGMDRD322 | FK 866 | 3 |
| iGMDRD286 | Nsc 632839 | 8 |
| iGMDRD329 | Merck60 | 3 |
| iGMDRD267 | Oligomycin A | 3 |
| iGMDRD103 | SN-38 | 3 |
| iGMDRD121 | GMX1778 | 3 |
| iGMDRD202 | Curcumin | 3 |
| iGMDRD158 | NSC141540 | 3 |
| iGMDRD211 | (1S,3R)-RSL3 | 3 |
| iGMDRD177 | Teniposide | 3 |
| iGMDRD341 | Triacsin c | 3 |
| iGMDRD116 | CD437 | 3 |
| iGMDRD560 | MK-2206 | 1 |
| iGMDRD150 | RITA | 3 |
| iGMDRD512 | nutlin 3 | 1 |
| iGMDRD399 | Selumetinib | 3 |
| iGMDRD506 | Fedratinib | 7 |
| iGMDRD398 | Sepantronium | 2 |
| iGMDRD780 | PP-30 | 2 |
| iGMDRD52 | Rotenone | 3 |
| iGMDRD870 | BRD63610 | 3 |
| iGMDRD679 | Bistramide A | 4 |
| iGMDRD634 | SCHEMBL2608041 | 3 |
| iGMDRD446 | LY 2183240 | 1 |
| iGMDRD316 | N9-Isopropyl-olomoucine | 3 |
| iGMDRD61 | Kinetin riboside | 2 |
| iGMDRD670 | ML 210 | 3 |
| iGMDRD144 | NSC95397 | 5 |
| iGMDRD494 | Neopeltolide | 3 |
| iGMDRD772 | BRD4770 | 2 |
| iGMDRD420 | Leucascandrolide A | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ADAMTS19
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