PER1


Summary: This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene may increase the risk of getting certain cancers. Alternative splicing has been observed in this gene; however, these variants have not been fully described. [provided by RefSeq, Jan 2014].

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GO terms in PER1


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Term Type
Evidence Type
GO Term ID
GO Des.
BP IBA GO:0000122 negative regulation of transcription by RNA polymerase II
BP ISS GO:0000122 negative regulation of transcription by RNA polymerase II
BP ISS GO:0002028 regulation of sodium ion transport
BP IEA GO:0006351 transcription, DNA-templated
BP IEP GO:0007623 circadian rhythm
BP IBA GO:0009416 response to light stimulus
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Gene expression in normal tissue: PER1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

undefined19PI3K/MTOR signaling2Proteasome1Purine metabolism1Terpenoid backbone biosynthesis1DNA replication1Chromatin other1Mitosis1Metabolism1Apoptosis regulation1

Pathways in PER1


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Database
Pathway ID
Pathway Des.
wikipathways WP1797 Circadian Clock
wikipathways WP3298 Melatonin metabolism and effects
wikipathways WP3355 BMAL1-CLOCK,NPAS2 activates circadian gene expression
wikipathways WP410 Exercise-induced Circadian Regulation
kegg hsa04710 Circadian rhythm - Homo sapiens (human)
kegg hsa04713 Circadian entrainment - Homo sapiens (human)
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD60 Quinoclamine 3
iGMDRD505 Pevonedistat 1
iGMDRD300 Tozasertib 3
iGMDRD322 FK 866 3
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PER1

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
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