PER1
Summary: This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene may increase the risk of getting certain cancers. Alternative splicing has been observed in this gene; however, these variants have not been fully described. [provided by RefSeq, Jan 2014].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
OMIM IDMIM:602260 Ensembl IDEnsembl:ENSG00000179094 HGNC IDHGNC:HGNC:8845 PHARMGKB IDPA33184 Map Location17p13.1 |
GO terms in PER1
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Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
BP | IBA | GO:0000122 | negative regulation of transcription by RNA polymerase II |
BP | ISS | GO:0000122 | negative regulation of transcription by RNA polymerase II |
BP | ISS | GO:0002028 | regulation of sodium ion transport |
BP | IEA | GO:0006351 | transcription, DNA-templated |
BP | IEP | GO:0007623 | circadian rhythm |
BP | IBA | GO:0009416 | response to light stimulus |
Gene expression in normal tissue: PER1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PER1
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Database | Pathway ID | Pathway Des. |
---|---|---|
wikipathways | WP1797 | Circadian Clock |
wikipathways | WP3298 | Melatonin metabolism and effects |
wikipathways | WP3355 | BMAL1-CLOCK,NPAS2 activates circadian gene expression |
wikipathways | WP410 | Exercise-induced Circadian Regulation |
kegg | hsa04710 | Circadian rhythm - Homo sapiens (human) |
kegg | hsa04713 | Circadian entrainment - Homo sapiens (human) |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot

Gene-drug targets distribution
Gene Structure: PDB
Models in PER1
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
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No matching records found |