N4BP2 Summary: This gene encodes a protein containing a polynucleotide kinase domain (PNK) near the N-terminal region, and a Small MutS Related (Smr) domain near the C-terminal region. The encoded protein can bind to both B-cell leukemia/lymphoma 3 (BCL-3) and neural precursor cell expressed, developmentally downregulated 4, (Nedd4) proteins. This protein binds and hydrolyzes ATP, may function as a 5'-polynucleotide kinase, and has the capacity to be a ubiquitylation substrate. This protein may play a role in transcription-coupled DNA repair or genetic recombination. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016].
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Gene expression in normal tissue: N4BP2
Select Project:
Transcriptome or Gene expression: PRJEB2445
Transcriptome or Gene expression: PRJEB4337
Transcriptome or Gene expression: PRJNA270632
Transcriptome or Gene expression: PRJNA280600
16 tissues mixture adipose adrenal brain breast colon heart kidney liver lung lymph node ovary prostate skeletal muscle testes thyroid white blood cells Export visualization to SVG
Gene-model tissue-cancer distribution: Bubble Plot undefine tissue: undefine
cancer: undefined
model num: 0 undefined tissue: undefined
cancer: PANCAN
model num: 89 undefined tissue: undefined
cancer: ADENOCARCINOMA
model num: 6 BOWE tissue: BOWE
cancer: BOWEL
model num: 0 BOWEL tissue: BOWEL
cancer: undefined
model num: 52 LUN tissue: LUN
cancer: LUNG
model num: 0 LUNG tissue: LUNG
cancer: undefined
model num: 4
Export visualization to SVG Gene-drug pathway distribution undefined 45 Apoptosis regulation 2 Other, kinases 1 Metabolic pathways 1 Arachidonic acid metabolism 1 ERK MAPK signaling 1 Biosynthesis of secondary metabolites 1 Metabolism 1 DNA replication 1 Ferroptosis 1
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Pathways in N4BP2
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Database
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No matching records found
Gene-Drug: Aster Plot
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Gene in drug-gene network: Network Plot ADAMTS20 ADAMTS20 OBSCN OBSCN VAV1 VAV1 EGFR EGFR STAT5A STAT5A TBCK TBCK RORA RORA LATS1 LATS1 CLSTN1 CLSTN1 CHD8 CHD8 HDAC8 HDAC8 Pevonedistat Pevonedistat PXDN PXDN ZNF217 ZNF217 DLC1 DLC1 TRPM7 TRPM7 NUP210 NUP210 ARTN ARTN C1D C1D COL14A1 COL14A1 STAC2 STAC2 EPHA7 EPHA7 KMT2C KMT2C KDR KDR MAP2K1 MAP2K1 SMURF2 SMURF2 IL1B IL1B PRKCG PRKCG MYH11 MYH11 AZD-1775 AZD-1775 DSTYK DSTYK ITGB6 ITGB6 MSN MSN FGFR1 FGFR1 PSKH2 PSKH2 HOXD13 HOXD13 CNTRL CNTRL CSNK2A2 CSNK2A2 LRP1B LRP1B FASN FASN AACOCF3 AACOCF3 EP300 EP300 HDAC4 HDAC4 MAML1 MAML1 MERTK MERTK NFKB1 NFKB1 MYLK MYLK NPC26 NPC26 XIAP XIAP DRD2 DRD2 CREBBP CREBBP MYCL MYCL BIRC2 BIRC2 OSR1 OSR1 AMER1 AMER1 MFSD2A MFSD2A RET RET LOC654780 LOC654780 FAM118A FAM118A ACKR3 ACKR3 KDM6A KDM6A Quiflapon Quiflapon NKX2-1 NKX2-1 FLI1 FLI1 NFKBIA NFKBIA WRN WRN AKAP6 AKAP6 GAK GAK TEK TEK SOS1 SOS1 HERC2 HERC2 PICALM PICALM MBIP MBIP RB1 RB1 PKN2 PKN2 STK25 STK25 PARP1 PARP1 EPHA5 EPHA5 FK 866 FK 866 RASA3 RASA3 RARA RARA PCDH15 PCDH15 MLH1 MLH1 RPS6KA3 RPS6KA3 P4HB P4HB YWHAQ YWHAQ ADHFE1 ADHFE1 TOP2A TOP2A Nsc 632839 Nsc 632839 ABCA3 ABCA3 ADK ADK TTK TTK FGF4 FGF4 ADGRG4 ADGRG4 TMEM74 TMEM74 PKMYT1 PKMYT1 MAP4K2 MAP4K2 ERN1 ERN1 RICTOR RICTOR PRKG1 PRKG1 PIGU PIGU KSR2 KSR2 PIK3C2G PIK3C2G BRD6368 BRD6368 PRKCB PRKCB GPR183 GPR183 HOXD10 HOXD10 SMOX SMOX MATK MATK CYP27B1 CYP27B1 DDX1 DDX1 CUBN CUBN RHEB RHEB STK24 STK24 CIITA CIITA Merck60 Merck60 ZMYM2 ZMYM2 LMNB1 LMNB1 MARK4 MARK4 LASP1 LASP1 PIP4K2B PIP4K2B BRIP1 BRIP1 TOX3 TOX3 CYFIP1 CYFIP1 STK11 STK11 ARHGEF7 ARHGEF7 CYP2B6 CYP2B6 PIK3CA PIK3CA PTK6 PTK6 WNK2 WNK2 SUZ12 SUZ12 DEK DEK GRK2 GRK2 MAPK10 MAPK10 Triptolide Triptolide P2RX7 P2RX7 PHOX2B PHOX2B ABL2 ABL2 SRPK2 SRPK2 EIF4A1 EIF4A1 POU2AF1 POU2AF1 PKDCC PKDCC BMPR1A BMPR1A BMI1 BMI1 CLTCL1 CLTCL1 MSH3 MSH3 GLI1 GLI1 STAR STAR EPHB3 EPHB3 ATP11A ATP11A AM-580 AM-580 ERC1 ERC1 KRAS KRAS CHRNA5 CHRNA5 URB2 URB2 GUCY1A2 GUCY1A2 IKZF3 IKZF3 SYK SYK BRCA1 BRCA1 BRCA2 BRCA2 DNAH8 DNAH8 LRRK2 LRRK2 PTEN PTEN MYLK3 MYLK3 PRPF4B PRPF4B HECW1 HECW1 GRB7 GRB7 BMS-536924 BMS-536924 SOX11 SOX11 SIK2 SIK2 KAT6B KAT6B CDKN2A CDKN2A CHD9 CHD9 CYP1A2 CYP1A2 PIK3CG PIK3CG TFR2 TFR2 DHFR DHFR CDKN2B CDKN2B SMR000068650 SMR000068650 SERPINB4 SERPINB4 HIF1A HIF1A ITGAV ITGAV ANAPC5 ANAPC5 BRAF BRAF CDC5L CDC5L CACNA1F CACNA1F ERCC6 ERCC6 JAK1 JAK1 ZNF331 ZNF331 DAPK1 DAPK1 ACVRL1 ACVRL1 GRIA3 GRIA3 Importazole Importazole EPHA2 EPHA2 FGR FGR TNK2 TNK2 SIX4 SIX4 ADGRB1 ADGRB1 MGA MGA FLNC FLNC KIT KIT PIM3 PIM3 Indisulam Indisulam SOX2 SOX2 UNC13C UNC13C ERBB4 ERBB4 JARID2 JARID2 GSK3A GSK3A CLTC CLTC FGFR4 FGFR4 RAD50 RAD50 PPARGC1A PPARGC1A NSC141540 NSC141540 NUTM1 NUTM1 LAMA1 LAMA1 MAST4 MAST4 ROBO2 ROBO2 PTCH1 PTCH1 STAG3 STAG3 TOX4 TOX4 GMX1778 GMX1778 FBN1 FBN1 NANOS3 NANOS3 CCDC50 CCDC50 CNTN5 CNTN5 GMPS GMPS TAF1 TAF1 DST DST NKD2 NKD2 ITPR2 ITPR2 PALB2 PALB2 (1S,3R)-RSL3 (1S,3R)-RSL3 KCNH2 KCNH2 NEK1 NEK1 PDCD1 PDCD1 HDAC2 HDAC2 PHIP PHIP TPH1 TPH1 CTNNA2 CTNNA2 FOXP1 FOXP1 PAX3 PAX3 LRGUK LRGUK PEAK1 PEAK1 WAS WAS Isoevodiamine Isoevodiamine CHEK1 CHEK1 DBN1 DBN1 ITGA7 ITGA7 NSC23766 NSC23766 SERPINA2 SERPINA2 AKT1 AKT1 CHN1 CHN1 MAPK7 MAPK7 CSNK1G2 CSNK1G2 TMPRSS2 TMPRSS2 CNTN6 CNTN6 ML214 ML214 CDK19 CDK19 SMARCA4 SMARCA4 REPS1 REPS1 PTGS2 PTGS2 PDCD11 PDCD11 RASGRF2 RASGRF2 SMAD3 SMAD3 EXT3 EXT3 ZFP69B ZFP69B CBL CBL FANCL FANCL ZNF423 ZNF423 GPHN GPHN ROCK1 ROCK1 NRAS NRAS CDH15 CDH15 Chloropentafluorobenzene Chloropentafluorobenzene HMGA2 HMGA2 KALRN KALRN IDH1 IDH1 CDH2 CDH2 BLK BLK PIK3R4 PIK3R4 ABT-751 ABT-751 EPHA4 EPHA4 ACACB ACACB STK40 STK40 TCEA1 TCEA1 TP53 TP53 TIE1 TIE1 PER1 PER1 CD160 CD160 TP63 TP63 SLC22A15 SLC22A15 TNFRSF4 TNFRSF4 IRAK2 IRAK2 Gemcitabine Gemcitabine ICAM1 ICAM1 NOTCH1 NOTCH1 PKHD1 PKHD1 ROBO1 ROBO1 NYNRIN NYNRIN BMP4 BMP4 PEX5L PEX5L MDM2 MDM2 Lovastatin acid Lovastatin acid SDCCAG8 SDCCAG8 Manumycin A Manumycin A MAML3 MAML3 TRRAP TRRAP NR2F1 NR2F1 RNASEL RNASEL FHIT FHIT AKT3 AKT3 PBX1 PBX1 Pifithrin-mu Pifithrin-mu EPHA3 EPHA3 SMAD4 SMAD4 IL17RD IL17RD NEK9 NEK9 KDM5A KDM5A Parbendazole Parbendazole RANBP17 RANBP17 ERBB2 ERBB2 BTRC BTRC PML PML PSIP1 PSIP1 MLLT1 MLLT1 GRIK1 GRIK1 ITGA5 ITGA5 NEK4 NEK4 DCLK1 DCLK1 PHKG1 PHKG1 Quinoclamine Quinoclamine LRRC7 LRRC7 TENM1 TENM1 MINK1 MINK1 EPHA6 EPHA6 TRAF6 TRAF6 PRAME PRAME HRAS HRAS Gossypol Gossypol MMP2 MMP2 SMARCB1 SMARCB1 PTPRD PTPRD BNIP3 BNIP3 IL1RN IL1RN Serdemetan Serdemetan MSH6 MSH6 PI4KA PI4KA KNL1 KNL1 NTRK1 NTRK1 DNAAF3 DNAAF3 LIFR LIFR Zebularine Zebularine ITIH6 ITIH6 NLRP1 NLRP1 CDX2 CDX2 PIK3CB PIK3CB NF1 NF1 Selumetinib Selumetinib MIEN1 MIEN1 SERPINB1 SERPINB1 PLPP5 PLPP5 WNK1 WNK1 STARD3 STARD3 HSPA4 HSPA4 CSF3 CSF3 Fedratinib Fedratinib PPARD PPARD AFDN AFDN CASP1 CASP1 ITGA10 ITGA10 YAP1 YAP1 IL3 IL3 TANK TANK PDPK1 PDPK1 BIX01294 BIX01294 TLE1 TLE1 CMC4 CMC4 BRCC3 BRCC3 F8 F8 Compound 44 Compound 44 ADCK1 ADCK1 NUP98 NUP98 LMTK2 LMTK2 LGR5 LGR5 MAPK6 MAPK6 UBR5 UBR5 NR4A3 NR4A3 ERN2 ERN2 RPS6KA2 RPS6KA2 PSKH1 PSKH1 MAPK14 MAPK14 MLKL MLKL STK17B STK17B Sepantronium Sepantronium TSHR TSHR TET1 TET1 ARFGEF1 ARFGEF1 PDZRN4 PDZRN4 ADAMTS2 ADAMTS2 INHBA INHBA PRKD1 PRKD1 LRP6 LRP6 PROC PROC Capsaicin Capsaicin ARHGAP29 ARHGAP29 MAP2K3 MAP2K3 DC-45-A2 DC-45-A2 FN1 FN1 IRS1 IRS1 FMO4 FMO4 PHF3 PHF3 KMT2A KMT2A CYB5R4 CYB5R4 RAD21 RAD21 PAC-1 PAC-1 WWTR1 WWTR1 PXK PXK PREX2 PREX2 NANOS2 NANOS2 CHL1 CHL1 FLNB FLNB PDE4DIP PDE4DIP MYH10 MYH10 BIRC6 BIRC6 RIPK3 RIPK3 KU0060648 KU0060648 ITK ITK NTRK3 NTRK3 PX 12 PX 12 KPNA5 KPNA5 ORMDL3 ORMDL3 IL6ST IL6ST MYC MYC ATP13A5 ATP13A5 TAF1L TAF1L ELAVL1 ELAVL1 SB225002 SB225002 NIPBL NIPBL MAP3K1 MAP3K1 FQI-2 FQI-2 AIFM3 AIFM3 MAP3K20 MAP3K20 CYLD CYLD RXRA RXRA CTDSPL CTDSPL ALK ALK ATM ATM CIC CIC TRIP13 TRIP13 ADAMTS18 ADAMTS18 GDNF GDNF NTRK2 NTRK2 CAMK4 CAMK4 Bistramide A Bistramide A PIP5K1B PIP5K1B RPTOR RPTOR FRK FRK CYTOCHALASIN B CYTOCHALASIN B LRP2 LRP2 SIK3 SIK3 CACNB2 CACNB2 ALPK2 ALPK2 GRK7 GRK7 JAG1 JAG1 LY 2183240 LY 2183240 FES FES PLCB2 PLCB2 TAF15 TAF15 PAPPA PAPPA PAK5 PAK5 TRIM28 TRIM28 TET2 TET2 Valdecoxib Valdecoxib YK 4-279 YK 4-279 PRKG2 PRKG2 TWF1 TWF1 MRE11 MRE11 GLG1 GLG1 RGL2 RGL2 MAP2K7 MAP2K7 PPP1R3A PPP1R3A STAT6 STAT6 TNN TNN GRIN2B GRIN2B Kinetin riboside Kinetin riboside MYH9 MYH9 NCAM1 NCAM1 Fqi1 Fqi1 GPR141 GPR141 ROS1 ROS1 PIK3C3 PIK3C3 EIF2AK4 EIF2AK4 NRK NRK PRL-3 Inhibitor I PRL-3 Inhibitor I TYK2 TYK2 DPYD DPYD ML 210 ML 210 MAP4K5 MAP4K5 CHM-1 CHM-1 CDKL2 CDKL2 COL3A1 COL3A1 FGFR3 FGFR3 Lexibulin Lexibulin MAP2K4 MAP2K4 Salermide Salermide FBN2 FBN2 MTUS2 MTUS2 IFNA2 IFNA2 Leucascandrolide A Leucascandrolide A N4BP2 N4BP2
Export visualization to SVG Gene-drug targets distribution
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Gene Structure: PDB
