N4BP2


Summary: This gene encodes a protein containing a polynucleotide kinase domain (PNK) near the N-terminal region, and a Small MutS Related (Smr) domain near the C-terminal region. The encoded protein can bind to both B-cell leukemia/lymphoma 3 (BCL-3) and neural precursor cell expressed, developmentally downregulated 4, (Nedd4) proteins. This protein binds and hydrolyzes ATP, may function as a 5'-polynucleotide kinase, and has the capacity to be a ubiquitylation substrate. This protein may play a role in transcription-coupled DNA repair or genetic recombination. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
NEDD4 binding protein 2Ensembl:ENSG00000078177HGNC:HGNC:29851PA1623965804p14

Gene Categories:

KINASE

GO terms in N4BP2


Term TypeEvidence TypeGO Term IDGO Des.
BPIEAGO:0016310phosphorylation
BPIEAGO:0090305nucleic acid phosphodiester bond hydrolysis
CCIEAGO:0005829cytosol
MFIDAGO:0004519endonuclease activity
MFIPIGO:0005515protein binding
MFIDAGO:0005524ATP binding
MFIDAGO:0046404ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity

Gene expression in normal tissue: N4BP2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in N4BP2


DatabasePathway IDPathway Des.

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD505Pevonedistat1
iGMDRD552AZD-17753
iGMDRD263AACOCF31
iGMDRD246NPC262
iGMDRD82Quiflapon2
iGMDRD322FK 8662
iGMDRD286Nsc 6328392
iGMDRD871BRD63686
iGMDRD329Merck606
iGMDRD105Triptolide2
iGMDRD6AM-5802
iGMDRD434BMS-5369241
iGMDRD213SMR0000686502
iGMDRD231Importazole4
iGMDRD137Indisulam1
iGMDRD158NSC1415402
iGMDRD121GMX17783
iGMDRD211(1S,3R)-RSL32
iGMDRD123Isoevodiamine4
iGMDRD154NSC237661
iGMDRD945ML2143
iGMDRD57Chloropentafluorobenzene2
iGMDRD237ABT-7513
iGMDRD79Gemcitabine1
iGMDRD84Lovastatin acid2
iGMDRD307Manumycin A2
iGMDRD148Pifithrin-mu2
iGMDRD64Parbendazole3
iGMDRD60Quinoclamine2
iGMDRD23Gossypol2
iGMDRD451Serdemetan3
iGMDRD100Zebularine2
iGMDRD399Selumetinib3
iGMDRD506Fedratinib2
iGMDRD577BIX012942
iGMDRD888Compound 443
iGMDRD398Sepantronium3
iGMDRD207Capsaicin1
iGMDRD782DC-45-A24
iGMDRD318PAC-16
iGMDRD480KU00606483
iGMDRD138PX 124
iGMDRD255SB2250023
iGMDRD260FQI-24
iGMDRD679Bistramide A2
iGMDRD280CYTOCHALASIN B2
iGMDRD446LY 21832401
iGMDRD107Valdecoxib1
iGMDRD639YK 4-2793
iGMDRD61Kinetin riboside5
iGMDRD193Fqi15
iGMDRD779PRL-3 Inhibitor I3
iGMDRD670ML 2102
iGMDRD151CHM-14
iGMDRD433Lexibulin5
iGMDRD599Salermide2
iGMDRD420Leucascandrolide A2

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in N4BP2

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