N4BP2
Summary: This gene encodes a protein containing a polynucleotide kinase domain (PNK) near the N-terminal region, and a Small MutS Related (Smr) domain near the C-terminal region. The encoded protein can bind to both B-cell leukemia/lymphoma 3 (BCL-3) and neural precursor cell expressed, developmentally downregulated 4, (Nedd4) proteins. This protein binds and hydrolyzes ATP, may function as a 5'-polynucleotide kinase, and has the capacity to be a ubiquitylation substrate. This protein may play a role in transcription-coupled DNA repair or genetic recombination. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| NEDD4 binding protein 2 | Ensembl:ENSG00000078177 | HGNC:HGNC:29851 | PA162396580 | 4p14 |
Gene Categories:
KINASEGO terms in N4BP2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IEA | GO:0016310 | phosphorylation |
| BP | IEA | GO:0090305 | nucleic acid phosphodiester bond hydrolysis |
| CC | IEA | GO:0005829 | cytosol |
| MF | IDA | GO:0004519 | endonuclease activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0005524 | ATP binding |
| MF | IDA | GO:0046404 | ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity |
Gene expression in normal tissue: N4BP2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in N4BP2
| Database | Pathway ID | Pathway Des. |
|---|
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD505 | Pevonedistat | 1 |
| iGMDRD552 | AZD-1775 | 3 |
| iGMDRD263 | AACOCF3 | 1 |
| iGMDRD246 | NPC26 | 2 |
| iGMDRD82 | Quiflapon | 2 |
| iGMDRD322 | FK 866 | 2 |
| iGMDRD286 | Nsc 632839 | 2 |
| iGMDRD871 | BRD6368 | 6 |
| iGMDRD329 | Merck60 | 6 |
| iGMDRD105 | Triptolide | 2 |
| iGMDRD6 | AM-580 | 2 |
| iGMDRD434 | BMS-536924 | 1 |
| iGMDRD213 | SMR000068650 | 2 |
| iGMDRD231 | Importazole | 4 |
| iGMDRD137 | Indisulam | 1 |
| iGMDRD158 | NSC141540 | 2 |
| iGMDRD121 | GMX1778 | 3 |
| iGMDRD211 | (1S,3R)-RSL3 | 2 |
| iGMDRD123 | Isoevodiamine | 4 |
| iGMDRD154 | NSC23766 | 1 |
| iGMDRD945 | ML214 | 3 |
| iGMDRD57 | Chloropentafluorobenzene | 2 |
| iGMDRD237 | ABT-751 | 3 |
| iGMDRD79 | Gemcitabine | 1 |
| iGMDRD84 | Lovastatin acid | 2 |
| iGMDRD307 | Manumycin A | 2 |
| iGMDRD148 | Pifithrin-mu | 2 |
| iGMDRD64 | Parbendazole | 3 |
| iGMDRD60 | Quinoclamine | 2 |
| iGMDRD23 | Gossypol | 2 |
| iGMDRD451 | Serdemetan | 3 |
| iGMDRD100 | Zebularine | 2 |
| iGMDRD399 | Selumetinib | 3 |
| iGMDRD506 | Fedratinib | 2 |
| iGMDRD577 | BIX01294 | 2 |
| iGMDRD888 | Compound 44 | 3 |
| iGMDRD398 | Sepantronium | 3 |
| iGMDRD207 | Capsaicin | 1 |
| iGMDRD782 | DC-45-A2 | 4 |
| iGMDRD318 | PAC-1 | 6 |
| iGMDRD480 | KU0060648 | 3 |
| iGMDRD138 | PX 12 | 4 |
| iGMDRD255 | SB225002 | 3 |
| iGMDRD260 | FQI-2 | 4 |
| iGMDRD679 | Bistramide A | 2 |
| iGMDRD280 | CYTOCHALASIN B | 2 |
| iGMDRD446 | LY 2183240 | 1 |
| iGMDRD107 | Valdecoxib | 1 |
| iGMDRD639 | YK 4-279 | 3 |
| iGMDRD61 | Kinetin riboside | 5 |
| iGMDRD193 | Fqi1 | 5 |
| iGMDRD779 | PRL-3 Inhibitor I | 3 |
| iGMDRD670 | ML 210 | 2 |
| iGMDRD151 | CHM-1 | 4 |
| iGMDRD433 | Lexibulin | 5 |
| iGMDRD599 | Salermide | 2 |
| iGMDRD420 | Leucascandrolide A | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in N4BP2
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