UNC13C
Summary:
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
unc-13 homolog C | MIM:614568 | Ensembl:ENSG00000137766 | HGNC:HGNC:23149 | PA134870087 | 15q21.3 |
GO terms in UNC13C
Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
MF | IEA | GO:0005509 | calcium ion binding |
MF | IBA | GO:0005516 | calmodulin binding |
MF | IEA | GO:0005543 | phospholipid binding |
MF | IBA | GO:0017075 | syntaxin-1 binding |
MF | IEA | GO:0019992 | diacylglycerol binding |
BP | ISS | GO:0007268 | chemical synaptic transmission |
BP | IBA | GO:0007528 | neuromuscular junction development |
BP | IBA | GO:0016081 | synaptic vesicle docking |
BP | IBA | GO:0016082 | synaptic vesicle priming |
BP | IBA | GO:0016188 | synaptic vesicle maturation |
BP | IEA | GO:0031914 | negative regulation of synaptic plasticity |
BP | IBA | GO:0035249 | synaptic transmission, glutamatergic |
BP | IEA | GO:0035556 | intracellular signal transduction |
BP | IBA | GO:0061789 | dense core granule priming |
BP | IBA | GO:0099525 | presynaptic dense core vesicle exocytosis |
CC | IEA | GO:0005737 | cytoplasm |
CC | IBA | GO:0005886 | plasma membrane |
CC | ISS | GO:0005886 | plasma membrane |
CC | IEA | GO:0030054 | cell junction |
CC | IBA | GO:0030672 | synaptic vesicle membrane |
CC | IBA | GO:0031594 | neuromuscular junction |
CC | IBA | GO:0042734 | presynaptic membrane |
CC | IEA | GO:0042734 | presynaptic membrane |
CC | IBA | GO:0043195 | terminal bouton |
CC | IEA | GO:0044305 | calyx of Held |
CC | IBA | GO:0048786 | presynaptic active zone |
CC | TAS | GO:0048786 | presynaptic active zone |
CC | IBA | GO:0098831 | presynaptic active zone cytoplasmic component |
Gene expression in normal tissue: UNC13C
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in UNC13C
Database | Pathway ID | Pathway Des. |
---|---|---|
kegg | hsa04721 | Synaptic vesicle cycle - Homo sapiens (human) |
wikipathways | WP2267 | Synaptic Vesicle Pathway |
Gene-Drug: Aster Plot
Drug ID | Drug Name | Model Num. |
---|---|---|
iGMDRD494 | Neopeltolide | 2 |
iGMDRD781 | Sirolimus | 4 |
iGMDRD427 | ABT737 | 6 |
iGMDRD546 | BMS-754807 | 2 |
iGMDRD670 | ML 210 | 2 |
iGMDRD420 | Leucascandrolide A | 5 |
iGMDRD1008 | SR-II-138A | 5 |
iGMDRD772 | BRD4770 | 3 |
iGMDRD151 | CHM-1 | 3 |
iGMDRD554 | CHEMBL1434137 | 3 |
iGMDRD433 | Lexibulin | 2 |
iGMDRD718 | Pyrvinium pamoate | 4 |
iGMDRD639 | YK 4-279 | 2 |
iGMDRD61 | Kinetin riboside | 3 |
iGMDRD193 | Fqi1 | 2 |
iGMDRD446 | LY 2183240 | 3 |
iGMDRD201 | SKI II | 5 |
iGMDRD318 | PAC-1 | 2 |
iGMDRD801 | 2,4-dideoxy-DC-45-A2 | 2 |
iGMDRD782 | DC-45-A2 | 6 |
iGMDRD260 | FQI-2 | 3 |
iGMDRD138 | PX 12 | 4 |
iGMDRD524 | ISX-9 | 3 |
iGMDRD690 | PRIMA-1MET | 2 |
iGMDRD60 | Quinoclamine | 2 |
iGMDRD64 | Parbendazole | 3 |
iGMDRD577 | BIX01294 | 5 |
iGMDRD562 | Navitoclax | 4 |
iGMDRD188 | Piperlongumine | 2 |
iGMDRD399 | Selumetinib | 4 |
iGMDRD79 | Gemcitabine | 6 |
iGMDRD560 | MK-2206 | 3 |
iGMDRD116 | CD437 | 2 |
iGMDRD532 | Olaparib | 3 |
iGMDRD512 | nutlin 3 | 3 |
iGMDRD84 | Lovastatin acid | 3 |
iGMDRD307 | Manumycin A | 5 |
iGMDRD123 | Isoevodiamine | 2 |
iGMDRD177 | Teniposide | 8 |
iGMDRD351 | GW843682X | 2 |
iGMDRD237 | ABT-751 | 1 |
iGMDRD415 | LE-135 | 3 |
iGMDRD267 | Oligomycin A | 2 |
iGMDRD231 | Importazole | 1 |
iGMDRD289 | Parthenolide | 2 |
iGMDRD105 | Triptolide | 1 |
iGMDRD705 | Nakiterpiosin | 2 |
iGMDRD434 | BMS-536924 | 2 |
iGMDRD103 | SN-38 | 5 |
iGMDRD202 | Curcumin | 7 |
iGMDRD158 | NSC141540 | 7 |
iGMDRD137 | Indisulam | 2 |
iGMDRD82 | Quiflapon | 3 |
iGMDRD505 | Pevonedistat | 5 |
iGMDRD246 | NPC26 | 5 |
iGMDRD329 | Merck60 | 4 |
iGMDRD414 | MST-312 | 2 |
iGMDRD872 | BRD7137 | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in UNC13C