PRKCSH

Summary: This gene encodes the beta-subunit of glucosidase II, an N-linked glycan-processing enzyme in the endoplasmic reticulum. The encoded protein is an acidic phosphoprotein known to be a substrate for protein kinase C. Mutations in this gene have been associated with the autosomal dominant polycystic liver disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Nameprotein kinase C substrate 80K-H
OMIM IDMIM:177060
Ensembl IDEnsembl:ENSG00000130175
HGNC IDHGNC:HGNC:9411
PHARMGKB IDPA33774
Map Location19p13.2

Gene Categories:

DRUGGABLE GENOME

GO terms in PRKCSH


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IPI GO:0005080 protein kinase C binding
MF IEA GO:0005509 calcium ion binding
MF IPI GO:0005515 protein binding
MF IPI GO:0044325 ion channel binding
MF IPI GO:0051219 phosphoprotein binding
BP IDA GO:0006491 N-glycan processing
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Gene expression in normal tissue: PRKCSH

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

undefined25Biosynthesis of secondary metabolites1Other, kinases1WNT signaling1Leukocyte transendothelial migration1PI3K/MTOR signaling1DNA replication1ERK MAPK signaling1Metabolism1Apoptosis regulation1

Pathways in PRKCSH


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Database
Pathway ID
Pathway Des.
reactome R-HSA-168249 Innate Immune System
reactome R-HSA-168256 Immune System
reactome R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
reactome R-HSA-392499 Metabolism of proteins
reactome R-HSA-446203 Asparagine N-linked glycosylation
reactome R-HSA-532668 N-glycan trimming in the ER and Calnexin/Calreticulin cycle
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD267 Oligomycin A 4
iGMDRD6 AM-580 5
iGMDRD103 SN-38 3
iGMDRD353 PD0325901 2
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PRKCSH

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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