PRKCSH
Summary: This gene encodes the beta-subunit of glucosidase II, an N-linked glycan-processing enzyme in the endoplasmic reticulum. The encoded protein is an acidic phosphoprotein known to be a substrate for protein kinase C. Mutations in this gene have been associated with the autosomal dominant polycystic liver disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| protein kinase C substrate 80K-H | MIM:177060 | Ensembl:ENSG00000130175 | HGNC:HGNC:9411 | PA33774 | 19p13.2 |
Gene Categories:
DRUGGABLE GENOMEGO terms in PRKCSH
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IPI | GO:0005080 | protein kinase C binding |
| MF | IEA | GO:0005509 | calcium ion binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IPI | GO:0044325 | ion channel binding |
| MF | IPI | GO:0051219 | phosphoprotein binding |
| BP | IDA | GO:0006491 | N-glycan processing |
| BP | NAS | GO:0035556 | intracellular signal transduction |
| BP | TAS | GO:0043687 | post-translational protein modification |
| BP | TAS | GO:0044267 | cellular protein metabolic process |
| CC | NAS | GO:0005622 | intracellular |
| CC | IDA | GO:0005783 | endoplasmic reticulum |
| CC | TAS | GO:0005788 | endoplasmic reticulum lumen |
| CC | IDA | GO:0017177 | glucosidase II complex |
| CC | IMP | GO:0043231 | intracellular membrane-bounded organelle |
Gene expression in normal tissue: PRKCSH
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PRKCSH
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-446203 | Asparagine N-linked glycosylation |
| reactome | R-HSA-532668 | N-glycan trimming in the ER and Calnexin/Calreticulin cycle |
| reactome | R-HSA-597592 | Post-translational protein modification |
| reactome | R-HSA-879415 | Advanced glycosylation endproduct receptor signaling |
| reactome | R-HSA-8957275 | Post-translational protein phosphorylation |
| reactome | R-HSA-901042 | Calnexin/calreticulin cycle |
| netpath | Pathway_Fibroblast__growth__factor-1 | Fibroblast growth factor-1 |
| kegg | hsa04141 | Protein processing in endoplasmic reticulum - Homo sapiens (human) |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD267 | Oligomycin A | 4 |
| iGMDRD6 | AM-580 | 5 |
| iGMDRD103 | SN-38 | 3 |
| iGMDRD353 | PD0325901 | 2 |
| iGMDRD322 | FK 866 | 1 |
| iGMDRD246 | NPC26 | 2 |
| iGMDRD286 | Nsc 632839 | 3 |
| iGMDRD560 | MK-2206 | 2 |
| iGMDRD154 | NSC23766 | 3 |
| iGMDRD132 | (-)-gallocatechin-3-O-gallate | 5 |
| iGMDRD237 | ABT-751 | 2 |
| iGMDRD85 | Ursolic acid | 3 |
| iGMDRD318 | PAC-1 | 5 |
| iGMDRD294 | Batimastat | 3 |
| iGMDRD782 | DC-45-A2 | 3 |
| iGMDRD255 | SB225002 | 2 |
| iGMDRD260 | FQI-2 | 4 |
| iGMDRD23 | Gossypol | 2 |
| iGMDRD874 | BRD8958 | 2 |
| iGMDRD60 | Quinoclamine | 5 |
| iGMDRD506 | Fedratinib | 1 |
| iGMDRD888 | Compound 44 | 2 |
| iGMDRD780 | PP-30 | 2 |
| iGMDRD779 | PRL-3 Inhibitor I | 2 |
| iGMDRD144 | NSC95397 | 3 |
| iGMDRD387 | CHIR-99021 | 2 |
| iGMDRD420 | Leucascandrolide A | 3 |
| iGMDRD772 | BRD4770 | 2 |
| iGMDRD433 | Lexibulin | 4 |
| iGMDRD151 | CHM-1 | 5 |
| iGMDRD280 | CYTOCHALASIN B | 4 |
| iGMDRD466 | Chaetocin | 3 |
| iGMDRD193 | Fqi1 | 2 |
| iGMDRD446 | LY 2183240 | 5 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PRKCSH
CLASSFICATION
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.