ADAM22
Summary: This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. Unlike other members of the ADAM protein family, the protein encoded by this gene lacks metalloprotease activity since it has no zinc-binding motif. This gene is highly expressed in the brain and may function as an integrin ligand in the brain. In mice, it has been shown to be essential for correct myelination in the peripheral nervous system. Alternative splicing results in several transcript variants.[provided by RefSeq, Dec 2010].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| ADAM metallopeptidase domain 22 | MIM:603709 | Ensembl:ENSG00000008277 | HGNC:HGNC:201 | PA24518 | 7q21.12 |
GO terms in ADAM22
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | TAS | GO:0005886 | plasma membrane |
| CC | ISS | GO:0016021 | integral component of membrane |
| CC | NAS | GO:0016021 | integral component of membrane |
| CC | ISS | GO:0030424 | axon |
| BP | IEA | GO:0006508 | proteolysis |
| BP | IEA | GO:0007155 | cell adhesion |
| BP | NAS | GO:0007162 | negative regulation of cell adhesion |
| BP | TAS | GO:0007417 | central nervous system development |
| BP | IEA | GO:0008344 | adult locomotory behavior |
| BP | IEA | GO:0022011 | myelination in peripheral nervous system |
| MF | IEA | GO:0004222 | metalloendopeptidase activity |
| MF | NAS | GO:0005178 | integrin binding |
| MF | IPI | GO:0005515 | protein binding |
Gene expression in normal tissue: ADAM22
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ADAM22
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-5682910 | LGI-ADAM interactions |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD871 | BRD6368 | 2 |
| iGMDRD286 | Nsc 632839 | 7 |
| iGMDRD872 | BRD7137 | 5 |
| iGMDRD329 | Merck60 | 2 |
| iGMDRD300 | Tozasertib | 4 |
| iGMDRD552 | AZD-1775 | 3 |
| iGMDRD103 | SN-38 | 1 |
| iGMDRD105 | Triptolide | 1 |
| iGMDRD434 | BMS-536924 | 2 |
| iGMDRD351 | GW843682X | 3 |
| iGMDRD211 | (1S,3R)-RSL3 | 3 |
| iGMDRD945 | ML214 | 2 |
| iGMDRD150 | RITA | 7 |
| iGMDRD560 | MK-2206 | 7 |
| iGMDRD424 | Tamatinib | 1 |
| iGMDRD188 | Piperlongumine | 2 |
| iGMDRD399 | Selumetinib | 2 |
| iGMDRD506 | Fedratinib | 6 |
| iGMDRD577 | BIX01294 | 3 |
| iGMDRD398 | Sepantronium | 2 |
| iGMDRD780 | PP-30 | 3 |
| iGMDRD23 | Gossypol | 2 |
| iGMDRD524 | ISX-9 | 5 |
| iGMDRD255 | SB225002 | 2 |
| iGMDRD318 | PAC-1 | 3 |
| iGMDRD885 | Compound 110 | 3 |
| iGMDRD280 | CYTOCHALASIN B | 2 |
| iGMDRD679 | Bistramide A | 3 |
| iGMDRD210 | AC55649 | 1 |
| iGMDRD889 | Compound 7d-cis | 2 |
| iGMDRD420 | Leucascandrolide A | 4 |
| iGMDRD670 | ML 210 | 3 |
| iGMDRD427 | ABT737 | 2 |
| iGMDRD144 | NSC95397 | 4 |
| iGMDRD494 | Neopeltolide | 5 |
| iGMDRD781 | Sirolimus | 6 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ADAM22
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