SPEG

Summary: This gene encodes a protein with similarity to members of the myosin light chain kinase family. This protein family is required for myocyte cytoskeletal development. Along with the desmin gene, expression of this gene may be controlled by the desmin locus control region. Mutations in this gene are associated with centronuclear myopathy 5. [provided by RefSeq, Jun 2016].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
NameSPEG complex locus
OMIM IDMIM:615950
Ensembl IDEnsembl:ENSG00000072195
HGNC IDHGNC:HGNC:16901
PHARMGKB IDPA142672598
Map Location2q35

GO terms in SPEG


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IBA GO:0004672 protein kinase activity
MF IEA GO:0004674 protein serine/threonine kinase activity
MF IPI GO:0005515 protein binding
MF IEA GO:0005524 ATP binding
BP IEA GO:0006468 protein phosphorylation
BP TAS GO:0007517 muscle organ development
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Gene expression in normal tissue: SPEG

Gene-model tissue-cancer distribution: Bubble Plot

BOWEtissue: BOWE cancer: BOWEL model num: 0BOWELtissue: BOWEL cancer: undefined model num: 29undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 45undefinedtissue: undefined cancer: SMALL_CELL_CARCINOMA model num: 3LUNtissue: LUN cancer: LUNG model num: 0LUNGtissue: LUNG cancer: undefined model num: 11OVARtissue: OVAR cancer: OVARY model num: 0OVARYtissue: OVARY cancer: undefined model num: 4

Gene-drug pathway distribution

undefined32Longevity regulating pathway1Proteasome1Apoptosis regulation1Purine metabolism1DNA replication1Metabolism1Biosynthesis of secondary metabolites1

Pathways in SPEG


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Database
Pathway ID
Pathway Des.
No matching records found

Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD6 AM-580 1
iGMDRD231 Importazole 2
iGMDRD267 Oligomycin A 2
iGMDRD103 SN-38 5
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in SPEG

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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