SPEG
Summary: This gene encodes a protein with similarity to members of the myosin light chain kinase family. This protein family is required for myocyte cytoskeletal development. Along with the desmin gene, expression of this gene may be controlled by the desmin locus control region. Mutations in this gene are associated with centronuclear myopathy 5. [provided by RefSeq, Jun 2016].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| SPEG complex locus | MIM:615950 | Ensembl:ENSG00000072195 | HGNC:HGNC:16901 | PA142672598 | 2q35 |
GO terms in SPEG
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0004672 | protein kinase activity |
| MF | IEA | GO:0004674 | protein serine/threonine kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| BP | IEA | GO:0006468 | protein phosphorylation |
| BP | TAS | GO:0007517 | muscle organ development |
| BP | TAS | GO:0008285 | negative regulation of cell proliferation |
| BP | IBA | GO:0042692 | muscle cell differentiation |
| BP | IEA | GO:0042692 | muscle cell differentiation |
| BP | IBA | GO:0072358 | cardiovascular system development |
| CC | IEA | GO:0005634 | nucleus |
Gene expression in normal tissue: SPEG
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in SPEG
| Database | Pathway ID | Pathway Des. |
|---|
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD6 | AM-580 | 1 |
| iGMDRD231 | Importazole | 2 |
| iGMDRD267 | Oligomycin A | 2 |
| iGMDRD103 | SN-38 | 5 |
| iGMDRD121 | GMX1778 | 4 |
| iGMDRD137 | Indisulam | 1 |
| iGMDRD82 | Quiflapon | 2 |
| iGMDRD322 | FK 866 | 3 |
| iGMDRD871 | BRD6368 | 3 |
| iGMDRD414 | MST-312 | 4 |
| iGMDRD67 | PENFLURIDOL | 2 |
| iGMDRD79 | Gemcitabine | 3 |
| iGMDRD405 | PIK-75 | 2 |
| iGMDRD330 | BRD4132 | 1 |
| iGMDRD248 | BRD4354 | 2 |
| iGMDRD123 | Isoevodiamine | 1 |
| iGMDRD132 | (-)-gallocatechin-3-O-gallate | 1 |
| iGMDRD154 | NSC23766 | 4 |
| iGMDRD341 | Triacsin c | 2 |
| iGMDRD237 | ABT-751 | 2 |
| iGMDRD782 | DC-45-A2 | 2 |
| iGMDRD870 | BRD63610 | 3 |
| iGMDRD255 | SB225002 | 1 |
| iGMDRD640 | CAY10618 | 3 |
| iGMDRD23 | Gossypol | 2 |
| iGMDRD577 | BIX01294 | 2 |
| iGMDRD888 | Compound 44 | 1 |
| iGMDRD562 | Navitoclax | 1 |
| iGMDRD779 | PRL-3 Inhibitor I | 1 |
| iGMDRD781 | Sirolimus | 3 |
| iGMDRD126 | Tipifarnib | 6 |
| iGMDRD599 | Salermide | 2 |
| iGMDRD420 | Leucascandrolide A | 2 |
| iGMDRD466 | Chaetocin | 2 |
| iGMDRD280 | CYTOCHALASIN B | 2 |
| iGMDRD634 | SCHEMBL2608041 | 6 |
| iGMDRD639 | YK 4-279 | 2 |
| iGMDRD61 | Kinetin riboside | 3 |
| iGMDRD152 | 179324-69-7 | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in SPEG
CLASSFICATION
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