GRK6


Summary: This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating their deactivation. Several transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008].

Loading, please wait...
Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location

GO terms in GRK6


Loading, please wait...
Term Type
Evidence Type
GO Term ID
GO Des.
MF IEA GO:0004703 G-protein coupled receptor kinase activity
MF IPI GO:0005515 protein binding
MF IEA GO:0005524 ATP binding
MF IDA GO:0047696 beta-adrenergic receptor kinase activity
MF IMP GO:0047696 beta-adrenergic receptor kinase activity
MF TAS GO:0047696 beta-adrenergic receptor kinase activity
Showing 1 to 6 of 12 rows rows per page

Gene expression in normal tissue: GRK6

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in GRK6


Loading, please wait...
Database
Pathway ID
Pathway Des.
reactome R-HSA-162582 Signal Transduction
reactome R-HSA-372790 Signaling by GPCR
reactome R-HSA-388396 GPCR downstream signalling
reactome R-HSA-418555 G alpha (s) signalling events
pid cxcr4_pathway CXCR4-mediated signaling events
kegg hsa04062 Chemokine signaling pathway - Homo sapiens (human)
Showing 1 to 6 of 15 rows rows per page

Gene-Drug: Aster Plot


Loading, please wait...
Drug ID
Drug Name
Model Num.
iGMDRD577 BIX01294 3
iGMDRD888 Compound 44 6
iGMDRD524 ISX-9 1
iGMDRD64 Parbendazole 6
Showing 1 to 4 of 21 rows rows per page

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in GRK6

Loading, please wait...
Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

​​​​