GRK6
Summary: This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating their deactivation. Several transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| G protein-coupled receptor kinase 6 | MIM:600869 | Ensembl:ENSG00000198055 | HGNC:HGNC:4545 | PA28942 | 5q35.3 |
GO terms in GRK6
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0004703 | G-protein coupled receptor kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IDA | GO:0047696 | beta-adrenergic receptor kinase activity |
| MF | IMP | GO:0047696 | beta-adrenergic receptor kinase activity |
| MF | TAS | GO:0047696 | beta-adrenergic receptor kinase activity |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | HDA | GO:0016020 | membrane |
| BP | IEA | GO:0006468 | protein phosphorylation |
| BP | TAS | GO:0007186 | G-protein coupled receptor signaling pathway |
| BP | TAS | GO:0008277 | regulation of G-protein coupled receptor protein signaling pathway |
| BP | IEA | GO:0016055 | Wnt signaling pathway |
Gene expression in normal tissue: GRK6
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in GRK6
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-372790 | Signaling by GPCR |
| reactome | R-HSA-388396 | GPCR downstream signalling |
| reactome | R-HSA-418555 | G alpha (s) signalling events |
| pid | cxcr4_pathway | CXCR4-mediated signaling events |
| kegg | hsa04062 | Chemokine signaling pathway - Homo sapiens (human) |
| kegg | hsa04144 | Endocytosis - Homo sapiens (human) |
| kegg | hsa05032 | Morphine addiction - Homo sapiens (human) |
| netpath | Pathway_CRH | CRH |
| netpath | Pathway_FSH | FSH |
| wikipathways | WP2035 | Follicle Stimulating Hormone (FSH) signaling pathway |
| wikipathways | WP2355 | Corticotropin-releasing hormone signaling pathway |
| wikipathways | WP289 | Myometrial Relaxation and Contraction Pathways |
| wikipathways | WP3929 | Chemokine signaling pathway |
| wikipathways | WP536 | Calcium Regulation in the Cardiac Cell |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD577 | BIX01294 | 3 |
| iGMDRD888 | Compound 44 | 6 |
| iGMDRD524 | ISX-9 | 1 |
| iGMDRD64 | Parbendazole | 6 |
| iGMDRD60 | Quinoclamine | 2 |
| iGMDRD300 | Tozasertib | 6 |
| iGMDRD255 | SB225002 | 1 |
| iGMDRD294 | Batimastat | 2 |
| iGMDRD318 | PAC-1 | 3 |
| iGMDRD705 | Nakiterpiosin | 3 |
| iGMDRD237 | ABT-751 | 2 |
| iGMDRD280 | CYTOCHALASIN B | 7 |
| iGMDRD123 | Isoevodiamine | 3 |
| iGMDRD901 | ELCPK | 3 |
| iGMDRD297 | Austocystin D | 7 |
| iGMDRD772 | BRD4770 | 4 |
| iGMDRD420 | Leucascandrolide A | 3 |
| iGMDRD889 | Compound 7d-cis | 3 |
| iGMDRD126 | Tipifarnib | 3 |
| iGMDRD781 | Sirolimus | 1 |
| iGMDRD560 | MK-2206 | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in GRK6
CLASSFICATION
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