TRIM33
Summary: The protein encoded by this gene is thought to be a transcriptional corepressor. However, molecules that interact with this protein have not yet been identified. The protein is a member of the tripartite motif family. This motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. Three alternatively spliced transcript variants for this gene have been described, however, the full-length nature of one variant has not been determined. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| tripartite motif containing 33 | MIM:605769 | Ensembl:ENSG00000197323 | HGNC:HGNC:16290 | PA38118 | 1p13.2 |
GO terms in TRIM33
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0003677 | DNA binding |
| MF | TAS | GO:0004842 | ubiquitin-protein transferase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0008270 | zinc ion binding |
| MF | IPI | GO:0070410 | co-SMAD binding |
| MF | IPI | GO:0070412 | R-SMAD binding |
| BP | TAS | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0006351 | transcription, DNA-templated |
| BP | IDA | GO:0016567 | protein ubiquitination |
| BP | IEA | GO:0016567 | protein ubiquitination |
| BP | IDA | GO:0017015 | regulation of transforming growth factor beta receptor signaling pathway |
| BP | IDA | GO:0030514 | negative regulation of BMP signaling pathway |
| BP | NAS | GO:0045892 | negative regulation of transcription, DNA-templated |
| CC | IDA | GO:0005634 | nucleus |
| CC | TAS | GO:0005654 | nucleoplasm |
Gene expression in normal tissue: TRIM33
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in TRIM33
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-170834 | Signaling by TGF-beta Receptor Complex |
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer |
| reactome | R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-9006936 | Signaling by TGF-beta family members |
| wikipathways | WP2858 | Ectoderm Differentiation |
| netpath | Pathway_TGF_beta_Receptor | TGF_beta_Receptor |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD341 | Triacsin c | 6 |
| iGMDRD237 | ABT-751 | 3 |
| iGMDRD219 | Bax channel blocker | 3 |
| iGMDRD679 | Bistramide A | 1 |
| iGMDRD280 | CYTOCHALASIN B | 3 |
| iGMDRD435 | BI-2536 | 2 |
| iGMDRD154 | NSC23766 | 3 |
| iGMDRD126 | Tipifarnib | 9 |
| iGMDRD151 | CHM-1 | 2 |
| iGMDRD307 | Manumycin A | 3 |
| iGMDRD579 | PF750 | 3 |
| iGMDRD420 | Leucascandrolide A | 2 |
| iGMDRD424 | Tamatinib | 6 |
| iGMDRD546 | BMS-754807 | 2 |
| iGMDRD286 | Nsc 632839 | 2 |
| iGMDRD577 | BIX01294 | 4 |
| iGMDRD506 | Fedratinib | 3 |
| iGMDRD780 | PP-30 | 3 |
| iGMDRD300 | Tozasertib | 1 |
| iGMDRD505 | Pevonedistat | 2 |
| iGMDRD705 | Nakiterpiosin | 2 |
| iGMDRD434 | BMS-536924 | 1 |
| iGMDRD885 | Compound 110 | 3 |
| iGMDRD481 | Dactolisib | 1 |
| iGMDRD77 | Itraconazole | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in TRIM33
CLASSFICATION
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