TRIM33


Summary: The protein encoded by this gene is thought to be a transcriptional corepressor. However, molecules that interact with this protein have not yet been identified. The protein is a member of the tripartite motif family. This motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. Three alternatively spliced transcript variants for this gene have been described, however, the full-length nature of one variant has not been determined. [provided by RefSeq, Jul 2008].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location

GO terms in TRIM33


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IEA GO:0003677 DNA binding
MF TAS GO:0004842 ubiquitin-protein transferase activity
MF IPI GO:0005515 protein binding
MF IEA GO:0008270 zinc ion binding
MF IPI GO:0070410 co-SMAD binding
MF IPI GO:0070412 R-SMAD binding
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Gene expression in normal tissue: TRIM33

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

undefined20PI3K/MTOR signaling1Mitosis1IGFR signaling1Cell cycle1Other, kinases1

Pathways in TRIM33


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Database
Pathway ID
Pathway Des.
reactome R-HSA-162582 Signal Transduction
reactome R-HSA-170834 Signaling by TGF-beta Receptor Complex
reactome R-HSA-212436 Generic Transcription Pathway
reactome R-HSA-2173793 Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
reactome R-HSA-2173795 Downregulation of SMAD2/3:SMAD4 transcriptional activity
reactome R-HSA-73857 RNA Polymerase II Transcription
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD341 Triacsin c 6
iGMDRD237 ABT-751 3
iGMDRD219 Bax channel blocker 3
iGMDRD679 Bistramide A 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in TRIM33

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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