TRIM33


Summary: The protein encoded by this gene is thought to be a transcriptional corepressor. However, molecules that interact with this protein have not yet been identified. The protein is a member of the tripartite motif family. This motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. Three alternatively spliced transcript variants for this gene have been described, however, the full-length nature of one variant has not been determined. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
tripartite motif containing 33MIM:605769Ensembl:ENSG00000197323HGNC:HGNC:16290PA381181p13.2

GO terms in TRIM33


Term TypeEvidence TypeGO Term IDGO Des.
MFIEAGO:0003677DNA binding
MFTASGO:0004842ubiquitin-protein transferase activity
MFIPIGO:0005515protein binding
MFIEAGO:0008270zinc ion binding
MFIPIGO:0070410co-SMAD binding
MFIPIGO:0070412R-SMAD binding
BPTASGO:0000122negative regulation of transcription by RNA polymerase II
BPIEAGO:0006351transcription, DNA-templated
BPIDAGO:0016567protein ubiquitination
BPIEAGO:0016567protein ubiquitination
BPIDAGO:0017015regulation of transforming growth factor beta receptor signaling pathway
BPIDAGO:0030514negative regulation of BMP signaling pathway
BPNASGO:0045892negative regulation of transcription, DNA-templated
CCIDAGO:0005634nucleus
CCTASGO:0005654nucleoplasm

Gene expression in normal tissue: TRIM33

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in TRIM33


DatabasePathway IDPathway Des.
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-170834Signaling by TGF-beta Receptor Complex
reactomeR-HSA-212436Generic Transcription Pathway
reactomeR-HSA-2173793Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
reactomeR-HSA-2173795Downregulation of SMAD2/3:SMAD4 transcriptional activity
reactomeR-HSA-73857RNA Polymerase II Transcription
reactomeR-HSA-74160Gene expression (Transcription)
reactomeR-HSA-9006936Signaling by TGF-beta family members
wikipathwaysWP2858Ectoderm Differentiation
netpathPathway_TGF_beta_ReceptorTGF_beta_Receptor

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD341Triacsin c6
iGMDRD237ABT-7513
iGMDRD219Bax channel blocker3
iGMDRD679Bistramide A1
iGMDRD280CYTOCHALASIN B3
iGMDRD435BI-25362
iGMDRD154NSC237663
iGMDRD126Tipifarnib9
iGMDRD151CHM-12
iGMDRD307Manumycin A3
iGMDRD579PF7503
iGMDRD420Leucascandrolide A2
iGMDRD424Tamatinib6
iGMDRD546BMS-7548072
iGMDRD286Nsc 6328392
iGMDRD577BIX012944
iGMDRD506Fedratinib3
iGMDRD780PP-303
iGMDRD300Tozasertib1
iGMDRD505Pevonedistat2
iGMDRD705Nakiterpiosin2
iGMDRD434BMS-5369241
iGMDRD885Compound 1103
iGMDRD481Dactolisib1
iGMDRD77Itraconazole3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in TRIM33

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