FANCE


Summary: The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group E. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
FA complementation group EMIM:613976Ensembl:ENSG00000112039HGNC:HGNC:3586PA280006p21.31

GO terms in FANCE


Term TypeEvidence TypeGO Term IDGO Des.
CCNASGO:0005634nucleus
CCTASGO:0005654nucleoplasm
CCIDAGO:0043240Fanconi anaemia nuclear complex
BPTASGO:0036297interstrand cross-link repair
MFNDGO:0003674molecular_function
MFIPIGO:0005515protein binding

Gene expression in normal tissue: FANCE

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in FANCE


DatabasePathway IDPathway Des.
biocartaatrbrcapathwayrole of brca1 brca2 and atr in cancer susceptibility
biocartabard1pathwaybrca1 dependent ub ligase activity
reactomeR-HSA-6783310Fanconi Anemia Pathway
reactomeR-HSA-73894DNA Repair
pidbard1pathwayBARD1 signaling events
pidfanconi_pathwayFanconi anemia pathway
kegghsa03460Fanconi anemia pathway - Homo sapiens (human)

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD599Salermide4
iGMDRD420Leucascandrolide A2
iGMDRD554CHEMBL14341374
iGMDRD210AC556492
iGMDRD433Lexibulin1
iGMDRD151CHM-12
iGMDRD494Neopeltolide3
iGMDRD781Sirolimus6
iGMDRD427ABT7372
iGMDRD546BMS-7548072
iGMDRD193Fqi11
iGMDRD634SCHEMBL26080412
iGMDRD679Bistramide A2
iGMDRD8024-methylfasudil2
iGMDRD260FQI-22
iGMDRD134Sorafenib2
iGMDRD138PX 123
iGMDRD318PAC-13
iGMDRD226ML0061
iGMDRD870BRD636101
iGMDRD782DC-45-A21
iGMDRD888Compound 441
iGMDRD577BIX012947
iGMDRD780PP-304
iGMDRD690PRIMA-1MET2
iGMDRD64Parbendazole2
iGMDRD60Quinoclamine2
iGMDRD248BRD43541
iGMDRD79Gemcitabine2
iGMDRD424Tamatinib2
iGMDRD351GW843682X1
iGMDRD57Chloropentafluorobenzene1
iGMDRD945ML2142
iGMDRD154NSC237665
iGMDRD177Teniposide5
iGMDRD103SN-382
iGMDRD158NSC1415405
iGMDRD271Brefeldin A2
iGMDRD68Paclitaxel2
iGMDRD105Triptolide4
iGMDRD6AM-5802
iGMDRD329Merck602
iGMDRD871BRD63681
iGMDRD286Nsc 6328391
iGMDRD872BRD71373
iGMDRD882CIL412
iGMDRD82Quiflapon2
iGMDRD886Compound 1541A2
iGMDRD246NPC262

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in FANCE

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