FANCE


Summary: The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group E. [provided by RefSeq, Jul 2008].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
OMIM IDMIM:613976
PHARMGKB IDPA28000
Map Location6p21.31

GO terms in FANCE


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Term Type
Evidence Type
GO Term ID
GO Des.
CC NAS GO:0005634 nucleus
CC TAS GO:0005654 nucleoplasm
CC IDA GO:0043240 Fanconi anaemia nuclear complex
BP TAS GO:0036297 interstrand cross-link repair
MF ND GO:0003674 molecular_function
MF IPI GO:0005515 protein binding
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Gene expression in normal tissue: FANCE

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in FANCE


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Database
Pathway ID
Pathway Des.
biocarta atrbrcapathway role of brca1 brca2 and atr in cancer susceptibility
biocarta bard1pathway brca1 dependent ub ligase activity
reactome R-HSA-6783310 Fanconi Anemia Pathway
reactome R-HSA-73894 DNA Repair
pid bard1pathway BARD1 signaling events
pid fanconi_pathway Fanconi anemia pathway
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD599 Salermide 4
iGMDRD420 Leucascandrolide A 2
iGMDRD554 CHEMBL1434137 4
iGMDRD210 AC55649 2
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in FANCE

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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