HSPA4
Summary:
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| heat shock protein family A (Hsp70) member 4 | MIM:601113 | Ensembl:ENSG00000170606 | HGNC:HGNC:5237 | PA29503 | 5q31.1 |
GO terms in HSPA4
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | NAS | GO:0006986 | response to unfolded protein |
| BP | IDA | GO:0045040 | protein import into mitochondrial outer membrane |
| BP | IDA | GO:0051131 | chaperone-mediated protein complex assembly |
| CC | IBA | GO:0005634 | nucleus |
| CC | IBA | GO:0005829 | cytosol |
| CC | IDA | GO:0005829 | cytosol |
| CC | HDA | GO:0070062 | extracellular exosome |
| CC | IDA | GO:0070062 | extracellular exosome |
| MF | IPI | GO:0005515 | protein binding |
| MF | NAS | GO:0005524 | ATP binding |
Gene expression in normal tissue: HSPA4
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in HSPA4
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-2262752 | Cellular responses to stress |
| reactome | R-HSA-3371453 | Regulation of HSF1-mediated heat shock response |
| reactome | R-HSA-3371556 | Cellular response to heat stress |
| reactome | R-HSA-8953897 | Cellular responses to external stimuli |
| wikipathways | WP2359 | Parkin-Ubiquitin Proteasomal System pathway |
| pid | myc_activpathway | Validated targets of C-MYC transcriptional activation |
| netpath | Pathway_AndrogenReceptor | AndrogenReceptor |
| pharmgkb | PA2027 | Glucocorticoid Pathway (Peripheral Tissue), Pharmacodynamics |
| kegg | hsa04530 | Tight junction - Homo sapiens (human) |
| kegg | hsa04612 | Antigen processing and presentation - Homo sapiens (human) |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD434 | BMS-536924 | 3 |
| iGMDRD289 | Parthenolide | 3 |
| iGMDRD187 | BRD9876 | 3 |
| iGMDRD267 | Oligomycin A | 3 |
| iGMDRD885 | Compound 110 | 3 |
| iGMDRD318 | PAC-1 | 6 |
| iGMDRD246 | NPC26 | 3 |
| iGMDRD886 | Compound 1541A | 3 |
| iGMDRD300 | Tozasertib | 3 |
| iGMDRD505 | Pevonedistat | 3 |
| iGMDRD451 | Serdemetan | 1 |
| iGMDRD188 | Piperlongumine | 6 |
| iGMDRD888 | Compound 44 | 6 |
| iGMDRD506 | Fedratinib | 9 |
| iGMDRD662 | JQ-1 | 3 |
| iGMDRD424 | Tamatinib | 3 |
| iGMDRD781 | Sirolimus | 6 |
| iGMDRD486 | Tosedostat | 1 |
| iGMDRD420 | Leucascandrolide A | 6 |
| iGMDRD394 | BX-795 | 3 |
| iGMDRD435 | BI-2536 | 6 |
| iGMDRD85 | Ursolic acid | 3 |
| iGMDRD446 | LY 2183240 | 4 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in HSPA4
CLASSFICATION
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