TAOK3


Summary: The protein encoded by this gene is a serine/threonine protein kinase that activates the p38/MAPK14 stress-activated MAPK cascade but inhibits the basal activity of the MAPK8/JNK cascade. The encoded protein is a member of the GCK subfamily of STE20-like kinases. [provided by RefSeq, Oct 2016].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
TAO kinase 3MIM:616711Ensembl:ENSG00000135090HGNC:HGNC:18133PA13497506412q24.23

GO terms in TAOK3


Term TypeEvidence TypeGO Term IDGO Des.
MFIBAGO:0004674protein serine/threonine kinase activity
MFIDAGO:0004674protein serine/threonine kinase activity
MFIBAGO:0004709MAP kinase kinase kinase activity
MFTASGO:0004860protein kinase inhibitor activity
MFIPIGO:0005515protein binding
MFIEAGO:0005524ATP binding
MFIDAGO:0016740transferase activity
CCIBAGO:0005634nucleus
CCIBAGO:0005737cytoplasm
CCIEAGO:0005886plasma membrane
BPIMPGO:0000165MAPK cascade
BPIBAGO:0000186activation of MAPKK activity
BPIEAGO:0000186activation of MAPKK activity
BPIEAGO:0006281DNA repair
BPIDAGO:0006468protein phosphorylation
BPIMPGO:0006468protein phosphorylation
BPIEAGO:0006469negative regulation of protein kinase activity
BPIDAGO:0006974cellular response to DNA damage stimulus
BPIMPGO:0007095mitotic G2 DNA damage checkpoint
BPIBAGO:0007346regulation of mitotic cell cycle
BPIBAGO:0023014signal transduction by protein phosphorylation
BPIBAGO:0032147activation of protein kinase activity
BPIMPGO:0032874positive regulation of stress-activated MAPK cascade
BPIMPGO:0043507positive regulation of JUN kinase activity
BPIDAGO:0046329negative regulation of JNK cascade
BPIMPGO:0046330positive regulation of JNK cascade
BPIDAGO:0046777protein autophosphorylation

Gene expression in normal tissue: TAOK3

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in TAOK3


DatabasePathway IDPathway Des.
wikipathwaysWP382MAPK Signaling Pathway
pidp38_mkk3_6pathwayp38 MAPK signaling pathway
kegghsa04010MAPK signaling pathway - Homo sapiens (human)

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD341Triacsin c5
iGMDRD71Sparfosic acid3
iGMDRD351GW843682X1
iGMDRD61Kinetin riboside4
iGMDRD152179324-69-71
iGMDRD679Bistramide A1
iGMDRD280CYTOCHALASIN B3
iGMDRD466Chaetocin3
iGMDRD76Simvastatin2
iGMDRD420Leucascandrolide A3
iGMDRD427ABT7373
iGMDRD494Neopeltolide3
iGMDRD188Piperlongumine3
iGMDRD286Nsc 6328392
iGMDRD871BRD63682
iGMDRD329Merck602
iGMDRD562Navitoclax3
iGMDRD886Compound 1541A2
iGMDRD268Cerulenin3
iGMDRD103SN-383
iGMDRD255SB2250026
iGMDRD870BRD636103

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in TAOK3

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