TAOK3
Summary: The protein encoded by this gene is a serine/threonine protein kinase that activates the p38/MAPK14 stress-activated MAPK cascade but inhibits the basal activity of the MAPK8/JNK cascade. The encoded protein is a member of the GCK subfamily of STE20-like kinases. [provided by RefSeq, Oct 2016].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| TAO kinase 3 | MIM:616711 | Ensembl:ENSG00000135090 | HGNC:HGNC:18133 | PA134975064 | 12q24.23 |
GO terms in TAOK3
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0004674 | protein serine/threonine kinase activity |
| MF | IDA | GO:0004674 | protein serine/threonine kinase activity |
| MF | IBA | GO:0004709 | MAP kinase kinase kinase activity |
| MF | TAS | GO:0004860 | protein kinase inhibitor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IDA | GO:0016740 | transferase activity |
| CC | IBA | GO:0005634 | nucleus |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IEA | GO:0005886 | plasma membrane |
| BP | IMP | GO:0000165 | MAPK cascade |
| BP | IBA | GO:0000186 | activation of MAPKK activity |
| BP | IEA | GO:0000186 | activation of MAPKK activity |
| BP | IEA | GO:0006281 | DNA repair |
| BP | IDA | GO:0006468 | protein phosphorylation |
| BP | IMP | GO:0006468 | protein phosphorylation |
| BP | IEA | GO:0006469 | negative regulation of protein kinase activity |
| BP | IDA | GO:0006974 | cellular response to DNA damage stimulus |
| BP | IMP | GO:0007095 | mitotic G2 DNA damage checkpoint |
| BP | IBA | GO:0007346 | regulation of mitotic cell cycle |
| BP | IBA | GO:0023014 | signal transduction by protein phosphorylation |
| BP | IBA | GO:0032147 | activation of protein kinase activity |
| BP | IMP | GO:0032874 | positive regulation of stress-activated MAPK cascade |
| BP | IMP | GO:0043507 | positive regulation of JUN kinase activity |
| BP | IDA | GO:0046329 | negative regulation of JNK cascade |
| BP | IMP | GO:0046330 | positive regulation of JNK cascade |
| BP | IDA | GO:0046777 | protein autophosphorylation |
Gene expression in normal tissue: TAOK3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in TAOK3
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP382 | MAPK Signaling Pathway |
| pid | p38_mkk3_6pathway | p38 MAPK signaling pathway |
| kegg | hsa04010 | MAPK signaling pathway - Homo sapiens (human) |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD341 | Triacsin c | 5 |
| iGMDRD71 | Sparfosic acid | 3 |
| iGMDRD351 | GW843682X | 1 |
| iGMDRD61 | Kinetin riboside | 4 |
| iGMDRD152 | 179324-69-7 | 1 |
| iGMDRD679 | Bistramide A | 1 |
| iGMDRD280 | CYTOCHALASIN B | 3 |
| iGMDRD466 | Chaetocin | 3 |
| iGMDRD76 | Simvastatin | 2 |
| iGMDRD420 | Leucascandrolide A | 3 |
| iGMDRD427 | ABT737 | 3 |
| iGMDRD494 | Neopeltolide | 3 |
| iGMDRD188 | Piperlongumine | 3 |
| iGMDRD286 | Nsc 632839 | 2 |
| iGMDRD871 | BRD6368 | 2 |
| iGMDRD329 | Merck60 | 2 |
| iGMDRD562 | Navitoclax | 3 |
| iGMDRD886 | Compound 1541A | 2 |
| iGMDRD268 | Cerulenin | 3 |
| iGMDRD103 | SN-38 | 3 |
| iGMDRD255 | SB225002 | 6 |
| iGMDRD870 | BRD63610 | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in TAOK3
CLASSFICATION
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