TAOK3

Summary: The protein encoded by this gene is a serine/threonine protein kinase that activates the p38/MAPK14 stress-activated MAPK cascade but inhibits the basal activity of the MAPK8/JNK cascade. The encoded protein is a member of the GCK subfamily of STE20-like kinases. [provided by RefSeq, Oct 2016].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
NameTAO kinase 3
OMIM IDMIM:616711
Ensembl IDEnsembl:ENSG00000135090
HGNC IDHGNC:HGNC:18133
PHARMGKB IDPA134975064
Map Location12q24.23

GO terms in TAOK3


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IBA GO:0004674 protein serine/threonine kinase activity
MF IDA GO:0004674 protein serine/threonine kinase activity
MF IBA GO:0004709 MAP kinase kinase kinase activity
MF TAS GO:0004860 protein kinase inhibitor activity
MF IPI GO:0005515 protein binding
MF IEA GO:0005524 ATP binding
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Gene expression in normal tissue: TAOK3

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 40BOWEtissue: BOWE cancer: BOWEL model num: 0BOWELtissue: BOWEL cancer: undefined model num: 6BLOOtissue: BLOO cancer: BLOOD model num: 0BLOODtissue: BLOOD cancer: undefined model num: 6OVARtissue: OVAR cancer: OVARY model num: 0OVARYtissue: OVARY cancer: undefined model num: 3UTERUtissue: UTERU cancer: UTERUS model num: 0UTERUStissue: UTERUS cancer: Endometrial Carcinoma (UCEC) model num: 3LUNtissue: LUN cancer: LUNG model num: 0LUNGtissue: LUNG cancer: undefined model num: 3

Gene-drug pathway distribution

Pathways in TAOK3


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Database
Pathway ID
Pathway Des.
wikipathways WP382 MAPK Signaling Pathway
pid p38_mkk3_6pathway p38 MAPK signaling pathway
kegg hsa04010 MAPK signaling pathway - Homo sapiens (human)
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD341 Triacsin c 5
iGMDRD71 Sparfosic acid 3
iGMDRD351 GW843682X 1
iGMDRD61 Kinetin riboside 4
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in TAOK3

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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