PLK4

Summary: This gene encodes a member of the polo family of serine/threonine protein kinases. The protein localizes to centrioles, complex microtubule-based structures found in centrosomes, and regulates centriole duplication during the cell cycle. Three alternatively spliced transcript variants that encode different protein isoforms have been found for this gene. [provided by RefSeq, Jun 2010].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Namepolo like kinase 4
OMIM IDMIM:605031
Ensembl IDEnsembl:ENSG00000142731
HGNC IDHGNC:HGNC:11397
PHARMGKB IDPA36205
Map Location4q28.1

GO terms in PLK4


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IDA GO:0004674 protein serine/threonine kinase activity
MF ISS GO:0004674 protein serine/threonine kinase activity
MF IPI GO:0005515 protein binding
MF IEA GO:0005524 ATP binding
MF IPI GO:0042802 identical protein binding
BP TAS GO:0000086 G2/M transition of mitotic cell cycle
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Gene expression in normal tissue: PLK4

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

undefined15PI3K/MTOR signaling2Cell cycle1Purine metabolism1Biosynthesis of secondary metabolites1Chromatin histone acetylation1Mitosis1Other, kinases1

Pathways in PLK4


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Database
Pathway ID
Pathway Des.
wikipathways WP2446 Retinoblastoma (RB) in Cancer
kegg hsa04068 FoxO signaling pathway - Homo sapiens (human)
reactome R-HSA-1640170 Cell Cycle
reactome R-HSA-1852241 Organelle biogenesis and maintenance
reactome R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition
reactome R-HSA-380259 Loss of Nlp from mitotic centrosomes
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD300 Tozasertib 3
iGMDRD887 Compound 23 citrate 3
iGMDRD506 Fedratinib 3
iGMDRD366 PI-103 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PLK4

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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