PLK4
Summary: This gene encodes a member of the polo family of serine/threonine protein kinases. The protein localizes to centrioles, complex microtubule-based structures found in centrosomes, and regulates centriole duplication during the cell cycle. Three alternatively spliced transcript variants that encode different protein isoforms have been found for this gene. [provided by RefSeq, Jun 2010].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| polo like kinase 4 | MIM:605031 | Ensembl:ENSG00000142731 | HGNC:HGNC:11397 | PA36205 | 4q28.1 |
GO terms in PLK4
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IDA | GO:0004674 | protein serine/threonine kinase activity |
| MF | ISS | GO:0004674 | protein serine/threonine kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IPI | GO:0042802 | identical protein binding |
| BP | TAS | GO:0000086 | G2/M transition of mitotic cell cycle |
| BP | IDA | GO:0006468 | protein phosphorylation |
| BP | IMP | GO:0007099 | centriole replication |
| BP | TAS | GO:0010389 | regulation of G2/M transition of mitotic cell cycle |
| BP | IDA | GO:0046601 | positive regulation of centriole replication |
| BP | IMP | GO:0046601 | positive regulation of centriole replication |
| BP | ISS | GO:0060707 | trophoblast giant cell differentiation |
| BP | TAS | GO:0097711 | ciliary basal body-plasma membrane docking |
| BP | ISS | GO:0098535 | de novo centriole assembly involved in multi-ciliated epithelial cell differentiation |
| CC | IEA | GO:0001741 | XY body |
| CC | ISS | GO:0005730 | nucleolus |
| CC | IDA | GO:0005813 | centrosome |
| CC | IDA | GO:0005814 | centriole |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | IEA | GO:0032154 | cleavage furrow |
| CC | ISS | GO:0098536 | deuterosome |
Gene expression in normal tissue: PLK4
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PLK4
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP2446 | Retinoblastoma (RB) in Cancer |
| kegg | hsa04068 | FoxO signaling pathway - Homo sapiens (human) |
| reactome | R-HSA-1640170 | Cell Cycle |
| reactome | R-HSA-1852241 | Organelle biogenesis and maintenance |
| reactome | R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition |
| reactome | R-HSA-380259 | Loss of Nlp from mitotic centrosomes |
| reactome | R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes |
| reactome | R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centrosome |
| reactome | R-HSA-380287 | Centrosome maturation |
| reactome | R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes |
| reactome | R-HSA-453274 | Mitotic G2-G2/M phases |
| reactome | R-HSA-5617833 | Cilium Assembly |
| reactome | R-HSA-5620912 | Anchoring of the basal body to the plasma membrane |
| reactome | R-HSA-68877 | Mitotic Prometaphase |
| reactome | R-HSA-68886 | M Phase |
| reactome | R-HSA-69275 | G2/M Transition |
| reactome | R-HSA-69278 | Cell Cycle, Mitotic |
| reactome | R-HSA-8854518 | AURKA Activation by TPX2 |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD300 | Tozasertib | 3 |
| iGMDRD887 | Compound 23 citrate | 3 |
| iGMDRD506 | Fedratinib | 3 |
| iGMDRD366 | PI-103 | 1 |
| iGMDRD705 | Nakiterpiosin | 3 |
| iGMDRD105 | Triptolide | 1 |
| iGMDRD289 | Parthenolide | 4 |
| iGMDRD52 | Rotenone | 3 |
| iGMDRD255 | SB225002 | 1 |
| iGMDRD123 | Isoevodiamine | 3 |
| iGMDRD435 | BI-2536 | 3 |
| iGMDRD945 | ML214 | 3 |
| iGMDRD132 | (-)-gallocatechin-3-O-gallate | 3 |
| iGMDRD219 | Bax channel blocker | 3 |
| iGMDRD560 | MK-2206 | 2 |
| iGMDRD670 | ML 210 | 2 |
| iGMDRD424 | Tamatinib | 2 |
| iGMDRD494 | Neopeltolide | 3 |
| iGMDRD79 | Gemcitabine | 1 |
| iGMDRD151 | CHM-1 | 3 |
| iGMDRD433 | Lexibulin | 1 |
| iGMDRD512 | nutlin 3 | 3 |
| iGMDRD420 | Leucascandrolide A | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PLK4
CLASSFICATION
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