ARHGDIB
Summary: Members of the Rho (or ARH) protein family (see MIM 165390) and other Ras-related small GTP-binding proteins (see MIM 179520) are involved in diverse cellular events, including cell signaling, proliferation, cytoskeletal organization, and secretion. The GTP-binding proteins are active only in the GTP-bound state. At least 3 classes of proteins tightly regulate cycling between the GTP-bound and GDP-bound states: GTPase-activating proteins (GAPs), guanine nucleotide-releasing factors (GRFs), and GDP-dissociation inhibitors (GDIs). The GDIs, including ARHGDIB, decrease the rate of GDP dissociation from Ras-like GTPases (summary by Scherle et al., 1993 [PubMed 8356058]).[supplied by OMIM, Dec 2010].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| Rho GDP dissociation inhibitor beta | MIM:602843 | Ensembl:ENSG00000111348 | HGNC:HGNC:679 | PA24964 | 12p12.3 |
GO terms in ARHGDIB
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IMP | GO:0003924 | GTPase activity |
| MF | IBA | GO:0005094 | Rho GDP-dissociation inhibitor activity |
| MF | IDA | GO:0005094 | Rho GDP-dissociation inhibitor activity |
| MF | IEA | GO:0005096 | GTPase activator activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0048365 | Rac GTPase binding |
| MF | IDA | GO:0048365 | Rac GTPase binding |
| BP | TAS | GO:0007162 | negative regulation of cell adhesion |
| BP | IBA | GO:0007266 | Rho protein signal transduction |
| BP | TAS | GO:0007275 | multicellular organism development |
| BP | IDA | GO:0035023 | regulation of Rho protein signal transduction |
| BP | IMP | GO:0035023 | regulation of Rho protein signal transduction |
| BP | IEA | GO:0043547 | positive regulation of GTPase activity |
| BP | TAS | GO:0051056 | regulation of small GTPase mediated signal transduction |
| BP | IEA | GO:0071461 | cellular response to redox state |
| BP | IDA | GO:1901164 | negative regulation of trophoblast cell migration |
| BP | IMP | GO:2000249 | regulation of actin cytoskeleton reorganization |
| CC | TAS | GO:0005737 | cytoplasm |
| CC | IBA | GO:0005829 | cytosol |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | TAS | GO:0005856 | cytoskeleton |
| CC | IBA | GO:0016020 | membrane |
| CC | IEA | GO:0016020 | membrane |
| CC | TAS | GO:0031410 | cytoplasmic vesicle |
| CC | HDA | GO:0070062 | extracellular exosome |
Gene expression in normal tissue: ARHGDIB
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ARHGDIB
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-194315 | Signaling by Rho GTPases |
| reactome | R-HSA-194840 | Rho GTPase cycle |
| biocarta | caspasepathway | caspase cascade in apoptosis |
| biocarta | d4gdipathway | d4gdi signaling pathway |
| biocarta | hivnefpathway | hiv-1 nef: negative effector of fas and tnf |
| netpath | Pathway_TCR | TCR |
| pid | caspase_pathway | Caspase Cascade in Apoptosis |
| pid | rhoa_reg_pathway | Regulation of RhoA activity |
| kegg | hsa04722 | Neurotrophin signaling pathway - Homo sapiens (human) |
| kegg | hsa04962 | Vasopressin-regulated water reabsorption - Homo sapiens (human) |
| wikipathways | WP314 | Fas Ligand (FasL) pathway and Stress induction of Heat Shock Proteins (HSP) regulation |
| wikipathways | WP524 | G13 Signaling Pathway |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD187 | BRD9876 | 6 |
| iGMDRD494 | Neopeltolide | 6 |
| iGMDRD420 | Leucascandrolide A | 3 |
| iGMDRD387 | CHIR-99021 | 1 |
| iGMDRD158 | NSC141540 | 3 |
| iGMDRD451 | Serdemetan | 3 |
| iGMDRD356 | PNU-74654 | 1 |
| iGMDRD280 | CYTOCHALASIN B | 3 |
| iGMDRD505 | Pevonedistat | 3 |
| iGMDRD886 | Compound 1541A | 3 |
| iGMDRD61 | Kinetin riboside | 1 |
| iGMDRD57 | Chloropentafluorobenzene | 3 |
| iGMDRD100 | Zebularine | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ARHGDIB
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