FCGR2B
Summary: The protein encoded by this gene is a low affinity receptor for the Fc region of immunoglobulin gamma complexes. The encoded protein is involved in the phagocytosis of immune complexes and in the regulation of antibody production by B-cells. Variations in this gene may increase susceptibilty to systemic lupus erythematosus (SLE). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| Fc fragment of IgG receptor IIb | MIM:604590 | Ensembl:ENSG00000072694 | HGNC:HGNC:3618 | PA28064 | 1q23.3 |
GO terms in FCGR2B
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IPI | GO:0001540 | amyloid-beta binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0019772 | low-affinity IgG receptor activity |
| MF | IDA | GO:0019864 | IgG binding |
| MF | IPI | GO:0044877 | protein-containing complex binding |
| BP | ISS | GO:0001811 | negative regulation of type I hypersensitivity |
| BP | TAS | GO:0001814 | negative regulation of antibody-dependent cellular cytotoxicity |
| BP | TAS | GO:0002266 | follicular dendritic cell activation |
| BP | TAS | GO:0002313 | mature B cell differentiation involved in immune response |
| BP | TAS | GO:0002316 | follicular B cell differentiation |
| BP | TAS | GO:0002436 | immune complex clearance by monocytes and macrophages |
| BP | TAS | GO:0002605 | negative regulation of dendritic cell antigen processing and presentation |
| BP | TAS | GO:0002622 | regulation of B cell antigen processing and presentation |
| BP | ISS | GO:0002638 | negative regulation of immunoglobulin production |
| BP | TAS | GO:0002819 | regulation of adaptive immune response |
| BP | ISS | GO:0002865 | negative regulation of acute inflammatory response to antigenic stimulus |
| BP | TAS | GO:0002922 | positive regulation of humoral immune response |
| BP | ISS | GO:0002924 | negative regulation of humoral immune response mediated by circulating immunoglobulin |
| BP | IDA | GO:0006898 | receptor-mediated endocytosis |
| BP | ISS | GO:0006911 | phagocytosis, engulfment |
| BP | ISS | GO:0006952 | defense response |
| BP | TAS | GO:0006954 | inflammatory response |
| BP | TAS | GO:0006955 | immune response |
| BP | TAS | GO:0007165 | signal transduction |
| BP | ISS | GO:0009617 | response to bacterium |
| BP | TAS | GO:0010469 | regulation of signaling receptor activity |
| BP | IEA | GO:0016032 | viral process |
| BP | ISS | GO:0016064 | immunoglobulin mediated immune response |
| BP | ISS | GO:0019886 | antigen processing and presentation of exogenous peptide antigen via MHC class II |
| BP | ISS | GO:0021549 | cerebellum development |
| BP | ISS | GO:0030889 | negative regulation of B cell proliferation |
| BP | ISS | GO:0032693 | negative regulation of interleukin-10 production |
| BP | IDA | GO:0038096 | Fc-gamma receptor signaling pathway involved in phagocytosis |
| BP | TAS | GO:0043031 | negative regulation of macrophage activation |
| BP | TAS | GO:0043318 | negative regulation of cytotoxic T cell degranulation |
| BP | TAS | GO:0045088 | regulation of innate immune response |
| BP | ISS | GO:0045576 | mast cell activation |
| BP | ISS | GO:0046330 | positive regulation of JNK cascade |
| BP | TAS | GO:0050710 | negative regulation of cytokine secretion |
| BP | TAS | GO:0050765 | negative regulation of phagocytosis |
| BP | ISS | GO:0050766 | positive regulation of phagocytosis |
| BP | TAS | GO:0050776 | regulation of immune response |
| BP | ISS | GO:0050777 | negative regulation of immune response |
| BP | TAS | GO:0050869 | negative regulation of B cell activation |
| BP | ISS | GO:0071219 | cellular response to molecule of bacterial origin |
| BP | TAS | GO:0090264 | regulation of immune complex clearance by monocytes and macrophages |
| BP | ISS | GO:1901216 | positive regulation of neuron death |
| BP | TAS | GO:1902564 | negative regulation of neutrophil activation |
| BP | IGI | GO:1902950 | regulation of dendritic spine maintenance |
| BP | ISS | GO:1904646 | cellular response to amyloid-beta |
| BP | ISS | GO:1905898 | positive regulation of response to endoplasmic reticulum stress |
| BP | TAS | GO:2001199 | negative regulation of dendritic cell differentiation |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IDA | GO:0005887 | integral component of plasma membrane |
| CC | ISS | GO:0009897 | external side of plasma membrane |
| CC | ISS | GO:0043197 | dendritic spine |
| CC | ISS | GO:0044297 | cell body |
Gene expression in normal tissue: FCGR2B
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in FCGR2B
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1280218 | Adaptive Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-198933 | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| netpath | Pathway_BCR | BCR |
| pid | bcr_5pathway | BCR signaling pathway |
| pid | fcer1pathway | Fc-epsilon receptor I signaling in mast cells |
| kegg | hsa04145 | Phagosome - Homo sapiens (human) |
| kegg | hsa04380 | Osteoclast differentiation - Homo sapiens (human) |
| kegg | hsa04662 | B cell receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa04666 | Fc gamma R-mediated phagocytosis - Homo sapiens (human) |
| kegg | hsa05150 | Staphylococcus aureus infection - Homo sapiens (human) |
| kegg | hsa05152 | Tuberculosis - Homo sapiens (human) |
| kegg | hsa05162 | Measles - Homo sapiens (human) |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD420 | Leucascandrolide A | 3 |
| iGMDRD300 | Tozasertib | 3 |
| iGMDRD781 | Sirolimus | 2 |
| iGMDRD79 | Gemcitabine | 3 |
| iGMDRD494 | Neopeltolide | 1 |
| iGMDRD634 | SCHEMBL2608041 | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in FCGR2B
CLASSFICATION
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