Summary: The protein encoded by this gene is a low affinity receptor for the Fc region of immunoglobulin gamma complexes. The encoded protein is involved in the phagocytosis of immune complexes and in the regulation of antibody production by B-cells. Variations in this gene may increase susceptibilty to systemic lupus erythematosus (SLE). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010].

Fc fragment of IgG receptor IIbMIM:604590Ensembl:ENSG00000072694HGNC:HGNC:3618PA280641q23.3

GO terms in FCGR2B

Term TypeEvidence TypeGO Term IDGO Des.
MFIPIGO:0001540amyloid-beta binding
MFIPIGO:0005515protein binding
MFIDAGO:0019772low-affinity IgG receptor activity
MFIDAGO:0019864IgG binding
MFIPIGO:0044877protein-containing complex binding
BPISSGO:0001811negative regulation of type I hypersensitivity
BPTASGO:0001814negative regulation of antibody-dependent cellular cytotoxicity
BPTASGO:0002266follicular dendritic cell activation
BPTASGO:0002313mature B cell differentiation involved in immune response
BPTASGO:0002316follicular B cell differentiation
BPTASGO:0002436immune complex clearance by monocytes and macrophages
BPTASGO:0002605negative regulation of dendritic cell antigen processing and presentation
BPTASGO:0002622regulation of B cell antigen processing and presentation
BPISSGO:0002638negative regulation of immunoglobulin production
BPTASGO:0002819regulation of adaptive immune response
BPISSGO:0002865negative regulation of acute inflammatory response to antigenic stimulus
BPTASGO:0002922positive regulation of humoral immune response
BPISSGO:0002924negative regulation of humoral immune response mediated by circulating immunoglobulin
BPIDAGO:0006898receptor-mediated endocytosis
BPISSGO:0006911phagocytosis, engulfment
BPISSGO:0006952defense response
BPTASGO:0006954inflammatory response
BPTASGO:0006955immune response
BPTASGO:0007165signal transduction
BPISSGO:0009617response to bacterium
BPTASGO:0010469regulation of signaling receptor activity
BPIEAGO:0016032viral process
BPISSGO:0016064immunoglobulin mediated immune response
BPISSGO:0019886antigen processing and presentation of exogenous peptide antigen via MHC class II
BPISSGO:0021549cerebellum development
BPISSGO:0030889negative regulation of B cell proliferation
BPISSGO:0032693negative regulation of interleukin-10 production
BPIDAGO:0038096Fc-gamma receptor signaling pathway involved in phagocytosis
BPTASGO:0043031negative regulation of macrophage activation
BPTASGO:0043318negative regulation of cytotoxic T cell degranulation
BPTASGO:0045088regulation of innate immune response
BPISSGO:0045576mast cell activation
BPISSGO:0046330positive regulation of JNK cascade
BPTASGO:0050710negative regulation of cytokine secretion
BPTASGO:0050765negative regulation of phagocytosis
BPISSGO:0050766positive regulation of phagocytosis
BPTASGO:0050776regulation of immune response
BPISSGO:0050777negative regulation of immune response
BPTASGO:0050869negative regulation of B cell activation
BPISSGO:0071219cellular response to molecule of bacterial origin
BPTASGO:0090264regulation of immune complex clearance by monocytes and macrophages
BPISSGO:1901216positive regulation of neuron death
BPTASGO:1902564negative regulation of neutrophil activation
BPIGIGO:1902950regulation of dendritic spine maintenance
BPISSGO:1904646cellular response to amyloid-beta
BPISSGO:1905898positive regulation of response to endoplasmic reticulum stress
BPTASGO:2001199negative regulation of dendritic cell differentiation
CCIDAGO:0005886plasma membrane
CCTASGO:0005886plasma membrane
CCIDAGO:0005887integral component of plasma membrane
CCISSGO:0009897external side of plasma membrane
CCISSGO:0043197dendritic spine
CCISSGO:0044297cell body

Gene expression in normal tissue: FCGR2B

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in FCGR2B

DatabasePathway IDPathway Des.
reactomeR-HSA-1280218Adaptive Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-198933Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
pidbcr_5pathwayBCR signaling pathway
pidfcer1pathwayFc-epsilon receptor I signaling in mast cells
kegghsa04145Phagosome - Homo sapiens (human)
kegghsa04380Osteoclast differentiation - Homo sapiens (human)
kegghsa04662B cell receptor signaling pathway - Homo sapiens (human)
kegghsa04666Fc gamma R-mediated phagocytosis - Homo sapiens (human)
kegghsa05150Staphylococcus aureus infection - Homo sapiens (human)
kegghsa05152Tuberculosis - Homo sapiens (human)
kegghsa05162Measles - Homo sapiens (human)

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.
iGMDRD420Leucascandrolide A3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in FCGR2B