FCGR2B

Summary: The protein encoded by this gene is a low affinity receptor for the Fc region of immunoglobulin gamma complexes. The encoded protein is involved in the phagocytosis of immune complexes and in the regulation of antibody production by B-cells. Variations in this gene may increase susceptibilty to systemic lupus erythematosus (SLE). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
NameFc fragment of IgG receptor IIb
OMIM IDMIM:604590
Ensembl IDEnsembl:ENSG00000072694
HGNC IDHGNC:HGNC:3618
PHARMGKB IDPA28064
Map Location1q23.3

GO terms in FCGR2B


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IPI GO:0001540 amyloid-beta binding
MF IPI GO:0005515 protein binding
MF IDA GO:0019772 low-affinity IgG receptor activity
MF IDA GO:0019864 IgG binding
MF IPI GO:0044877 protein-containing complex binding
BP ISS GO:0001811 negative regulation of type I hypersensitivity
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Gene expression in normal tissue: FCGR2B

Gene-model tissue-cancer distribution: Bubble Plot

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Gene-drug pathway distribution

undefined3Purine metabolism1Mitosis1Longevity regulating pathway1

Pathways in FCGR2B


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Database
Pathway ID
Pathway Des.
reactome R-HSA-1280218 Adaptive Immune System
reactome R-HSA-168256 Immune System
reactome R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
netpath Pathway_BCR BCR
pid bcr_5pathway BCR signaling pathway
pid fcer1pathway Fc-epsilon receptor I signaling in mast cells
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD420 Leucascandrolide A 3
iGMDRD300 Tozasertib 3
iGMDRD781 Sirolimus 2
iGMDRD79 Gemcitabine 3
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in FCGR2B

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
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