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ECM1

Summary: This gene encodes a soluble protein that is involved in endochondral bone formation, angiogenesis, and tumor biology. It also interacts with a variety of extracellular and structural proteins, contributing to the maintenance of skin integrity and homeostasis. Mutations in this gene are associated with lipoid proteinosis disorder (also known as hyalinosis cutis et mucosae or Urbach-Wiethe disease) that is characterized by generalized thickening of skin, mucosae and certain viscera. Alternatively spliced transcript variants encoding distinct isoforms have been described for this gene. [provided by RefSeq, Feb 2011].

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
extracellular matrix protein 1	MIM:602201	Ensembl:ENSG00000143369	HGNC:HGNC:3153	PA27598	1q21.2

Gene Categories:

DRUGGABLE GENOME PROTEASE

GO terms in ECM1

Term Type	Evidence Type	GO Term ID	GO Des.
MF	IPI	GO:0002020	protease binding
MF	IEA	GO:0005134	interleukin-2 receptor binding
MF	IPI	GO:0005515	protein binding
MF	IPI	GO:0008022	protein C-terminus binding
MF	IPI	GO:0019899	enzyme binding
MF	IPI	GO:0043236	laminin binding
CC	TAS	GO:0005576	extracellular region
CC	IDA	GO:0031012	extracellular matrix
CC	NAS	GO:0031012	extracellular matrix
CC	TAS	GO:0031089	platelet dense granule lumen
CC	HDA	GO:0062023	collagen-containing extracellular matrix
CC	HDA	GO:0070062	extracellular exosome
BP	IEA	GO:0001503	ossification
BP	IEA	GO:0001525	angiogenesis
BP	IDA	GO:0001938	positive regulation of endothelial cell proliferation
BP	IEA	GO:0001960	negative regulation of cytokine-mediated signaling pathway
BP	TAS	GO:0002576	platelet degranulation
BP	IEA	GO:0002828	regulation of type 2 immune response
BP	IEA	GO:0006357	regulation of transcription by RNA polymerase II
BP	IEA	GO:0006954	inflammatory response
BP	IEA	GO:0007165	signal transduction
BP	IDA	GO:0010466	negative regulation of peptidase activity
BP	IDA	GO:0030502	negative regulation of bone mineralization
BP	IEA	GO:0031214	biomineral tissue development
BP	HMP	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
BP	IDA	GO:0045766	positive regulation of angiogenesis
BP	IEA	GO:2000404	regulation of T cell migration

Gene expression in normal tissue: ECM1

Select Project:

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in ECM1

Database	Pathway ID	Pathway Des.
reactome	R-HSA-109582	Hemostasis
reactome	R-HSA-114608	Platelet degranulation
reactome	R-HSA-76002	Platelet activation, signaling and aggregation
reactome	R-HSA-76005	Response to elevated platelet cytosolic Ca2+

Gene-Drug: Aster Plot

Drug ID	Drug Name	Model Num.
iGMDRD77	Itraconazole	2
iGMDRD231	Importazole	3
iGMDRD188	Piperlongumine	3
iGMDRD871	BRD6368	3
iGMDRD286	Nsc 632839	4
iGMDRD399	Selumetinib	3
iGMDRD577	BIX01294	4
iGMDRD888	Compound 44	6
iGMDRD562	Navitoclax	1
iGMDRD398	Sepantronium	2
iGMDRD505	Pevonedistat	3
iGMDRD300	Tozasertib	3
iGMDRD886	Compound 1541A	2
iGMDRD60	Quinoclamine	3
iGMDRD126	Tipifarnib	1
iGMDRD387	CHIR-99021	1
iGMDRD889	Compound 7d-cis	3
iGMDRD248	BRD4354	1
iGMDRD420	Leucascandrolide A	2
iGMDRD150	RITA	4
iGMDRD144	NSC95397	4
iGMDRD427	ABT737	1
iGMDRD781	Sirolimus	2
iGMDRD79	Gemcitabine	3
iGMDRD446	LY 2183240	2
iGMDRD341	Triacsin c	4
iGMDRD718	Pyrvinium pamoate	1
iGMDRD152	179324-69-7	3
iGMDRD466	Chaetocin	1
iGMDRD154	NSC23766	3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ECM1

SITE

DATATYPES

CLASSFICATION

Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.