ECM1


Summary: This gene encodes a soluble protein that is involved in endochondral bone formation, angiogenesis, and tumor biology. It also interacts with a variety of extracellular and structural proteins, contributing to the maintenance of skin integrity and homeostasis. Mutations in this gene are associated with lipoid proteinosis disorder (also known as hyalinosis cutis et mucosae or Urbach-Wiethe disease) that is characterized by generalized thickening of skin, mucosae and certain viscera. Alternatively spliced transcript variants encoding distinct isoforms have been described for this gene. [provided by RefSeq, Feb 2011].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
extracellular matrix protein 1MIM:602201Ensembl:ENSG00000143369HGNC:HGNC:3153PA275981q21.2

Gene Categories:

DRUGGABLE GENOMEPROTEASE

GO terms in ECM1


Term TypeEvidence TypeGO Term IDGO Des.
MFIPIGO:0002020protease binding
MFIEAGO:0005134interleukin-2 receptor binding
MFIPIGO:0005515protein binding
MFIPIGO:0008022protein C-terminus binding
MFIPIGO:0019899enzyme binding
MFIPIGO:0043236laminin binding
CCTASGO:0005576extracellular region
CCIDAGO:0031012extracellular matrix
CCNASGO:0031012extracellular matrix
CCTASGO:0031089platelet dense granule lumen
CCHDAGO:0062023collagen-containing extracellular matrix
CCHDAGO:0070062extracellular exosome
BPIEAGO:0001503ossification
BPIEAGO:0001525angiogenesis
BPIDAGO:0001938positive regulation of endothelial cell proliferation
BPIEAGO:0001960negative regulation of cytokine-mediated signaling pathway
BPTASGO:0002576platelet degranulation
BPIEAGO:0002828regulation of type 2 immune response
BPIEAGO:0006357regulation of transcription by RNA polymerase II
BPIEAGO:0006954inflammatory response
BPIEAGO:0007165signal transduction
BPIDAGO:0010466negative regulation of peptidase activity
BPIDAGO:0030502negative regulation of bone mineralization
BPIEAGO:0031214biomineral tissue development
BPHMPGO:0043123positive regulation of I-kappaB kinase/NF-kappaB signaling
BPIDAGO:0045766positive regulation of angiogenesis
BPIEAGO:2000404regulation of T cell migration

Gene expression in normal tissue: ECM1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in ECM1


DatabasePathway IDPathway Des.
reactomeR-HSA-109582Hemostasis
reactomeR-HSA-114608Platelet degranulation
reactomeR-HSA-76002Platelet activation, signaling and aggregation
reactomeR-HSA-76005Response to elevated platelet cytosolic Ca2+

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD77Itraconazole2
iGMDRD231Importazole3
iGMDRD188Piperlongumine3
iGMDRD871BRD63683
iGMDRD286Nsc 6328394
iGMDRD399Selumetinib3
iGMDRD577BIX012944
iGMDRD888Compound 446
iGMDRD562Navitoclax1
iGMDRD398Sepantronium2
iGMDRD505Pevonedistat3
iGMDRD300Tozasertib3
iGMDRD886Compound 1541A2
iGMDRD60Quinoclamine3
iGMDRD126Tipifarnib1
iGMDRD387CHIR-990211
iGMDRD889Compound 7d-cis3
iGMDRD248BRD43541
iGMDRD420Leucascandrolide A2
iGMDRD150RITA4
iGMDRD144NSC953974
iGMDRD427ABT7371
iGMDRD781Sirolimus2
iGMDRD79Gemcitabine3
iGMDRD446LY 21832402
iGMDRD341Triacsin c4
iGMDRD718Pyrvinium pamoate1
iGMDRD152179324-69-73
iGMDRD466Chaetocin1
iGMDRD154NSC237663

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ECM1

​​​​