CAMK1
Summary: Calcium/calmodulin-dependent protein kinase I is expressed in many tissues and is a component of a calmodulin-dependent protein kinase cascade. Calcium/calmodulin directly activates calcium/calmodulin-dependent protein kinase I by binding to the enzyme and indirectly promotes the phosphorylation and synergistic activation of the enzyme by calcium/calmodulin-dependent protein kinase I kinase. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| calcium/calmodulin dependent protein kinase I | MIM:604998 | Ensembl:ENSG00000134072 | HGNC:HGNC:1459 | PA26048 | 3p25.3 |
GO terms in CAMK1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IBA | GO:0005622 | intracellular |
| CC | IEA | GO:0005634 | nucleus |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IEA | GO:0005737 | cytoplasm |
| BP | IDA | GO:0006468 | protein phosphorylation |
| BP | IEA | GO:0006913 | nucleocytoplasmic transport |
| BP | IEA | GO:0007049 | cell cycle |
| BP | TAS | GO:0007165 | signal transduction |
| BP | IDA | GO:0010976 | positive regulation of neuron projection development |
| BP | IBA | GO:0018105 | peptidyl-serine phosphorylation |
| BP | IBA | GO:0018107 | peptidyl-threonine phosphorylation |
| BP | IDA | GO:0032091 | negative regulation of protein binding |
| BP | IDA | GO:0032880 | regulation of protein localization |
| BP | IMP | GO:0033138 | positive regulation of peptidyl-serine phosphorylation |
| BP | IBA | GO:0035556 | intracellular signal transduction |
| BP | IDA | GO:0043393 | regulation of protein binding |
| BP | IMP | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IDA | GO:0046827 | positive regulation of protein export from nucleus |
| BP | IDA | GO:0051147 | regulation of muscle cell differentiation |
| BP | IMP | GO:0051149 | positive regulation of muscle cell differentiation |
| BP | IMP | GO:0051835 | positive regulation of synapse structural plasticity |
| BP | IMP | GO:0060143 | positive regulation of syncytium formation by plasma membrane fusion |
| BP | IMP | GO:0060999 | positive regulation of dendritic spine development |
| BP | IDA | GO:0071902 | positive regulation of protein serine/threonine kinase activity |
| BP | IMP | GO:1901985 | positive regulation of protein acetylation |
| BP | IMP | GO:2000615 | regulation of histone H3-K9 acetylation |
| MF | IBA | GO:0004674 | protein serine/threonine kinase activity |
| MF | IBA | GO:0004683 | calmodulin-dependent protein kinase activity |
| MF | ISS | GO:0004683 | calmodulin-dependent protein kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0005516 | calmodulin binding |
| MF | IEA | GO:0005524 | ATP binding |
Gene expression in normal tissue: CAMK1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CAMK1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa04921 | Oxytocin signaling pathway - Homo sapiens (human) |
| kegg | hsa04925 | Aldosterone synthesis and secretion - Homo sapiens (human) |
| pharmgkb | PA162356267 | EGFR Inhibitor Pathway, Pharmacodynamics |
| wikipathways | WP2380 | Brain-Derived Neurotrophic Factor (BDNF) signaling pathway |
| wikipathways | WP3680 | Association Between Physico-Chemical Features and Toxicity Associated Pathways |
| wikipathways | WP4018 | Pathways in clear cell renal cell carcinoma |
| wikipathways | WP536 | Calcium Regulation in the Cardiac Cell |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD248 | BRD4354 | 3 |
| iGMDRD772 | BRD4770 | 3 |
| iGMDRD420 | Leucascandrolide A | 3 |
| iGMDRD1008 | SR-II-138A | 3 |
| iGMDRD889 | Compound 7d-cis | 5 |
| iGMDRD151 | CHM-1 | 3 |
| iGMDRD126 | Tipifarnib | 1 |
| iGMDRD494 | Neopeltolide | 3 |
| iGMDRD116 | CD437 | 3 |
| iGMDRD152 | 179324-69-7 | 6 |
| iGMDRD61 | Kinetin riboside | 4 |
| iGMDRD351 | GW843682X | 3 |
| iGMDRD718 | Pyrvinium pamoate | 6 |
| iGMDRD314 | Tanespimycin | 3 |
| iGMDRD85 | Ursolic acid | 3 |
| iGMDRD123 | Isoevodiamine | 3 |
| iGMDRD280 | CYTOCHALASIN B | 1 |
| iGMDRD270 | Ciclosporin | 3 |
| iGMDRD705 | Nakiterpiosin | 3 |
| iGMDRD289 | Parthenolide | 6 |
| iGMDRD888 | Compound 44 | 6 |
| iGMDRD872 | BRD7137 | 6 |
| iGMDRD871 | BRD6368 | 6 |
| iGMDRD300 | Tozasertib | 6 |
| iGMDRD886 | Compound 1541A | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CAMK1
CLASSFICATION
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