CAMK1


Summary: Calcium/calmodulin-dependent protein kinase I is expressed in many tissues and is a component of a calmodulin-dependent protein kinase cascade. Calcium/calmodulin directly activates calcium/calmodulin-dependent protein kinase I by binding to the enzyme and indirectly promotes the phosphorylation and synergistic activation of the enzyme by calcium/calmodulin-dependent protein kinase I kinase. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
calcium/calmodulin dependent protein kinase IMIM:604998Ensembl:ENSG00000134072HGNC:HGNC:1459PA260483p25.3

GO terms in CAMK1


Term TypeEvidence TypeGO Term IDGO Des.
CCIBAGO:0005622intracellular
CCIEAGO:0005634nucleus
CCIBAGO:0005737cytoplasm
CCIEAGO:0005737cytoplasm
BPIDAGO:0006468protein phosphorylation
BPIEAGO:0006913nucleocytoplasmic transport
BPIEAGO:0007049cell cycle
BPTASGO:0007165signal transduction
BPIDAGO:0010976positive regulation of neuron projection development
BPIBAGO:0018105peptidyl-serine phosphorylation
BPIBAGO:0018107peptidyl-threonine phosphorylation
BPIDAGO:0032091negative regulation of protein binding
BPIDAGO:0032880regulation of protein localization
BPIMPGO:0033138positive regulation of peptidyl-serine phosphorylation
BPIBAGO:0035556intracellular signal transduction
BPIDAGO:0043393regulation of protein binding
BPIMPGO:0045944positive regulation of transcription by RNA polymerase II
BPIDAGO:0046827positive regulation of protein export from nucleus
BPIDAGO:0051147regulation of muscle cell differentiation
BPIMPGO:0051149positive regulation of muscle cell differentiation
BPIMPGO:0051835positive regulation of synapse structural plasticity
BPIMPGO:0060143positive regulation of syncytium formation by plasma membrane fusion
BPIMPGO:0060999positive regulation of dendritic spine development
BPIDAGO:0071902positive regulation of protein serine/threonine kinase activity
BPIMPGO:1901985positive regulation of protein acetylation
BPIMPGO:2000615regulation of histone H3-K9 acetylation
MFIBAGO:0004674protein serine/threonine kinase activity
MFIBAGO:0004683calmodulin-dependent protein kinase activity
MFISSGO:0004683calmodulin-dependent protein kinase activity
MFIPIGO:0005515protein binding
MFIBAGO:0005516calmodulin binding
MFIEAGO:0005524ATP binding

Gene expression in normal tissue: CAMK1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in CAMK1


DatabasePathway IDPathway Des.
kegghsa04921Oxytocin signaling pathway - Homo sapiens (human)
kegghsa04925Aldosterone synthesis and secretion - Homo sapiens (human)
pharmgkbPA162356267EGFR Inhibitor Pathway, Pharmacodynamics
wikipathwaysWP2380Brain-Derived Neurotrophic Factor (BDNF) signaling pathway
wikipathwaysWP3680Association Between Physico-Chemical Features and Toxicity Associated Pathways
wikipathwaysWP4018Pathways in clear cell renal cell carcinoma
wikipathwaysWP536Calcium Regulation in the Cardiac Cell

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD248BRD43543
iGMDRD772BRD47703
iGMDRD420Leucascandrolide A3
iGMDRD1008SR-II-138A3
iGMDRD889Compound 7d-cis5
iGMDRD151CHM-13
iGMDRD126Tipifarnib1
iGMDRD494Neopeltolide3
iGMDRD116CD4373
iGMDRD152179324-69-76
iGMDRD61Kinetin riboside4
iGMDRD351GW843682X3
iGMDRD718Pyrvinium pamoate6
iGMDRD314Tanespimycin3
iGMDRD85Ursolic acid3
iGMDRD123Isoevodiamine3
iGMDRD280CYTOCHALASIN B1
iGMDRD270Ciclosporin3
iGMDRD705Nakiterpiosin3
iGMDRD289Parthenolide6
iGMDRD888Compound 446
iGMDRD872BRD71376
iGMDRD871BRD63686
iGMDRD300Tozasertib6
iGMDRD886Compound 1541A3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CAMK1

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