EIF2AK4
Summary: This gene encodes a member of a family of kinases that phosphorylate the alpha subunit of eukaryotic translation initiation factor-2 (EIF2), resulting in the downregulaton of protein synthesis. The encoded protein responds to amino acid deprivation by binding uncharged transfer RNAs. It may also be activated by glucose deprivation and viral infection. Mutations in this gene have been found in individuals suffering from autosomal recessive pulmonary venoocclusive-disease-2. [provided by RefSeq, Mar 2014].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:609280 Ensembl IDEnsembl:ENSG00000128829 HGNC IDHGNC:HGNC:19687 PHARMGKB IDPA134947616 Map Location15q15.1 | |||||
GO terms in EIF2AK4
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Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | ISS | GO:0000049 | tRNA binding |
| MF | IBA | GO:0004672 | protein kinase activity |
| MF | ISS | GO:0004674 | protein serine/threonine kinase activity |
| MF | IBA | GO:0004694 | eukaryotic translation initiation factor 2alpha kinase activity |
| MF | IMP | GO:0004694 | eukaryotic translation initiation factor 2alpha kinase activity |
| MF | ISS | GO:0004694 | eukaryotic translation initiation factor 2alpha kinase activity |
Gene expression in normal tissue: EIF2AK4
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in EIF2AK4
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Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa04140 | Autophagy - animal - Homo sapiens (human) |
| kegg | hsa04141 | Protein processing in endoplasmic reticulum - Homo sapiens (human) |
| kegg | hsa05160 | Hepatitis C - Homo sapiens (human) |
| kegg | hsa05162 | Measles - Homo sapiens (human) |
| kegg | hsa05164 | Influenza A - Homo sapiens (human) |
| kegg | hsa05168 | Herpes simplex infection - Homo sapiens (human) |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in EIF2AK4
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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