EIF2AK4
Summary: This gene encodes a member of a family of kinases that phosphorylate the alpha subunit of eukaryotic translation initiation factor-2 (EIF2), resulting in the downregulaton of protein synthesis. The encoded protein responds to amino acid deprivation by binding uncharged transfer RNAs. It may also be activated by glucose deprivation and viral infection. Mutations in this gene have been found in individuals suffering from autosomal recessive pulmonary venoocclusive-disease-2. [provided by RefSeq, Mar 2014].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| eukaryotic translation initiation factor 2 alpha kinase 4 | MIM:609280 | Ensembl:ENSG00000128829 | HGNC:HGNC:19687 | PA134947616 | 15q15.1 |
GO terms in EIF2AK4
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | ISS | GO:0000049 | tRNA binding |
| MF | IBA | GO:0004672 | protein kinase activity |
| MF | ISS | GO:0004674 | protein serine/threonine kinase activity |
| MF | IBA | GO:0004694 | eukaryotic translation initiation factor 2alpha kinase activity |
| MF | IMP | GO:0004694 | eukaryotic translation initiation factor 2alpha kinase activity |
| MF | ISS | GO:0004694 | eukaryotic translation initiation factor 2alpha kinase activity |
| MF | IEA | GO:0005524 | ATP binding |
| BP | IEA | GO:0000077 | DNA damage checkpoint |
| BP | ISS | GO:0002230 | positive regulation of defense response to virus by host |
| BP | IEA | GO:0002250 | adaptive immune response |
| BP | ISS | GO:0002286 | T cell activation involved in immune response |
| BP | ISS | GO:0002821 | positive regulation of adaptive immune response |
| BP | ISS | GO:0006446 | regulation of translational initiation |
| BP | ISS | GO:0006468 | protein phosphorylation |
| BP | IEA | GO:0007050 | cell cycle arrest |
| BP | ISS | GO:0007612 | learning |
| BP | ISS | GO:0007616 | long-term memory |
| BP | IMP | GO:0010998 | regulation of translational initiation by eIF2 alpha phosphorylation |
| BP | ISS | GO:0010998 | regulation of translational initiation by eIF2 alpha phosphorylation |
| BP | ISS | GO:0019081 | viral translation |
| BP | ISS | GO:0032057 | negative regulation of translational initiation in response to stress |
| BP | ISS | GO:0032792 | negative regulation of CREB transcription factor activity |
| BP | IMP | GO:0034198 | cellular response to amino acid starvation |
| BP | ISS | GO:0034198 | cellular response to amino acid starvation |
| BP | ISS | GO:0034644 | cellular response to UV |
| BP | IMP | GO:0036492 | eiF2alpha phosphorylation in response to endoplasmic reticulum stress |
| BP | ISS | GO:0039520 | induction by virus of host autophagy |
| BP | ISS | GO:0044828 | negative regulation by host of viral genome replication |
| BP | ISS | GO:0045665 | negative regulation of neuron differentiation |
| BP | ISS | GO:0045947 | negative regulation of translational initiation |
| BP | ISS | GO:0046777 | protein autophosphorylation |
| BP | IEA | GO:0051607 | defense response to virus |
| BP | ISS | GO:0060259 | regulation of feeding behavior |
| BP | IMP | GO:0060733 | regulation of eIF2 alpha phosphorylation by amino acid starvation |
| BP | ISS | GO:0060733 | regulation of eIF2 alpha phosphorylation by amino acid starvation |
| BP | IMP | GO:0070417 | cellular response to cold |
| BP | ISS | GO:0071264 | positive regulation of translational initiation in response to starvation |
| BP | ISS | GO:1900273 | positive regulation of long-term synaptic potentiation |
| BP | ISS | GO:1990138 | neuron projection extension |
| BP | ISS | GO:1990253 | cellular response to leucine starvation |
| CC | ISS | GO:0005844 | polysome |
| CC | IBA | GO:0022626 | cytosolic ribosome |
| CC | ISS | GO:0022626 | cytosolic ribosome |
Gene expression in normal tissue: EIF2AK4
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in EIF2AK4
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa04140 | Autophagy - animal - Homo sapiens (human) |
| kegg | hsa04141 | Protein processing in endoplasmic reticulum - Homo sapiens (human) |
| kegg | hsa05160 | Hepatitis C - Homo sapiens (human) |
| kegg | hsa05162 | Measles - Homo sapiens (human) |
| kegg | hsa05164 | Influenza A - Homo sapiens (human) |
| kegg | hsa05168 | Herpes simplex infection - Homo sapiens (human) |
| kegg | hsa05169 | Epstein-Barr virus infection - Homo sapiens (human) |
| biocarta | eif2pathway | regulation of eif2 |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD177 | Teniposide | 6 |
| iGMDRD154 | NSC23766 | 3 |
| iGMDRD314 | Tanespimycin | 2 |
| iGMDRD351 | GW843682X | 2 |
| iGMDRD512 | nutlin 3 | 3 |
| iGMDRD148 | Pifithrin-mu | 3 |
| iGMDRD505 | Pevonedistat | 4 |
| iGMDRD147 | Prima-1 | 1 |
| iGMDRD42 | Vorinostat | 3 |
| iGMDRD872 | BRD7137 | 3 |
| iGMDRD705 | Nakiterpiosin | 1 |
| iGMDRD103 | SN-38 | 5 |
| iGMDRD158 | NSC141540 | 2 |
| iGMDRD137 | Indisulam | 3 |
| iGMDRD297 | Austocystin D | 3 |
| iGMDRD280 | CYTOCHALASIN B | 2 |
| iGMDRD359 | OSW-1 | 3 |
| iGMDRD427 | ABT737 | 3 |
| iGMDRD144 | NSC95397 | 2 |
| iGMDRD779 | PRL-3 Inhibitor I | 6 |
| iGMDRD494 | Neopeltolide | 3 |
| iGMDRD483 | SCH-529074 | 6 |
| iGMDRD781 | Sirolimus | 3 |
| iGMDRD151 | CHM-1 | 3 |
| iGMDRD420 | Leucascandrolide A | 5 |
| iGMDRD772 | BRD4770 | 2 |
| iGMDRD60 | Quinoclamine | 5 |
| iGMDRD399 | Selumetinib | 2 |
| iGMDRD562 | Navitoclax | 3 |
| iGMDRD398 | Sepantronium | 2 |
| iGMDRD171 | Pemetrexed | 2 |
| iGMDRD318 | PAC-1 | 2 |
| iGMDRD870 | BRD63610 | 1 |
| iGMDRD260 | FQI-2 | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in EIF2AK4
CLASSFICATION
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.