LMO1


Summary: This locus encodes a transcriptional regulator that contains two cysteine-rich LIM domains but lacks a DNA-binding domain. LIM domains may play a role in protein interactions; thus the encoded protein may regulate transcription by competitively binding to specific DNA-binding transcription factors. Alterations at this locus have been associated with acute lymphoblastic T-cell leukemia. Chromosomal rearrangements have been observed between this locus and at least two loci, the delta subunit of the T-cell antigen receptor gene and the LIM domain binding 1 gene. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2012].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
LIM domain only 1MIM:186921Ensembl:ENSG00000166407HGNC:HGNC:6641PA3040711p15.4

Gene Categories:

CLINICALLY ACTIONABLE

GO terms in LMO1


Term TypeEvidence TypeGO Term IDGO Des.
BPIEAGO:0000122negative regulation of transcription by RNA polymerase II
BPIMPGO:0045944positive regulation of transcription by RNA polymerase II
BPIEAGO:0046013regulation of T cell homeostatic proliferation
BPTASGO:1902036regulation of hematopoietic stem cell differentiation
CCISSGO:0005634nucleus
CCTASGO:0005654nucleoplasm
MFIPIGO:0005515protein binding
MFIEAGO:0046872metal ion binding

Gene expression in normal tissue: LMO1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in LMO1


DatabasePathway IDPathway Des.
reactomeR-HSA-212436Generic Transcription Pathway
reactomeR-HSA-73857RNA Polymerase II Transcription
reactomeR-HSA-74160Gene expression (Transcription)
reactomeR-HSA-8878171Transcriptional regulation by RUNX1
reactomeR-HSA-8939236RUNX1 regulates transcription of genes involved in differentiation of HSCs

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD219Bax channel blocker3
iGMDRD193Fqi13
iGMDRD446LY 21832403
iGMDRD435BI-25366
iGMDRD883CIL55A3
iGMDRD945ML2143
iGMDRD123Isoevodiamine3
iGMDRD420Leucascandrolide A3
iGMDRD126Tipifarnib3
iGMDRD151CHM-16
iGMDRD506Fedratinib6
iGMDRD366PI-1033
iGMDRD780PP-303
iGMDRD414MST-3121
iGMDRD871BRD63683
iGMDRD286Nsc 6328393
iGMDRD887Compound 23 citrate3
iGMDRD886Compound 1541A1
iGMDRD300Tozasertib3
iGMDRD121GMX17783
iGMDRD318PAC-11
iGMDRD105Triptolide3
iGMDRD289Parthenolide1
iGMDRD705Nakiterpiosin3
iGMDRD434BMS-5369243

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in LMO1

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