LMO1
Summary: This locus encodes a transcriptional regulator that contains two cysteine-rich LIM domains but lacks a DNA-binding domain. LIM domains may play a role in protein interactions; thus the encoded protein may regulate transcription by competitively binding to specific DNA-binding transcription factors. Alterations at this locus have been associated with acute lymphoblastic T-cell leukemia. Chromosomal rearrangements have been observed between this locus and at least two loci, the delta subunit of the T-cell antigen receptor gene and the LIM domain binding 1 gene. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2012].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| LIM domain only 1 | MIM:186921 | Ensembl:ENSG00000166407 | HGNC:HGNC:6641 | PA30407 | 11p15.4 |
Gene Categories:
CLINICALLY ACTIONABLEGO terms in LMO1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IEA | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | IMP | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0046013 | regulation of T cell homeostatic proliferation |
| BP | TAS | GO:1902036 | regulation of hematopoietic stem cell differentiation |
| CC | ISS | GO:0005634 | nucleus |
| CC | TAS | GO:0005654 | nucleoplasm |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0046872 | metal ion binding |
Gene expression in normal tissue: LMO1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in LMO1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-8878171 | Transcriptional regulation by RUNX1 |
| reactome | R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD219 | Bax channel blocker | 3 |
| iGMDRD193 | Fqi1 | 3 |
| iGMDRD446 | LY 2183240 | 3 |
| iGMDRD435 | BI-2536 | 6 |
| iGMDRD883 | CIL55A | 3 |
| iGMDRD945 | ML214 | 3 |
| iGMDRD123 | Isoevodiamine | 3 |
| iGMDRD420 | Leucascandrolide A | 3 |
| iGMDRD126 | Tipifarnib | 3 |
| iGMDRD151 | CHM-1 | 6 |
| iGMDRD506 | Fedratinib | 6 |
| iGMDRD366 | PI-103 | 3 |
| iGMDRD780 | PP-30 | 3 |
| iGMDRD414 | MST-312 | 1 |
| iGMDRD871 | BRD6368 | 3 |
| iGMDRD286 | Nsc 632839 | 3 |
| iGMDRD887 | Compound 23 citrate | 3 |
| iGMDRD886 | Compound 1541A | 1 |
| iGMDRD300 | Tozasertib | 3 |
| iGMDRD121 | GMX1778 | 3 |
| iGMDRD318 | PAC-1 | 1 |
| iGMDRD105 | Triptolide | 3 |
| iGMDRD289 | Parthenolide | 1 |
| iGMDRD705 | Nakiterpiosin | 3 |
| iGMDRD434 | BMS-536924 | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in LMO1
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