MCM3AP
Summary: The minichromosome maintenance protein 3 (MCM3) is one of the MCM proteins essential for the initiation of DNA replication. The protein encoded by this gene is a MCM3 binding protein. It was reported to have phosphorylation-dependent DNA-primase activity, which was up-regulated in antigen immunization induced germinal center. This protein was demonstrated to be an acetyltransferase that acetylates MCM3 and plays a role in DNA replication. The mutagenesis of a nuclear localization signal of MCM3 affects the binding of this protein with MCM3, suggesting that this protein may also facilitate MCM3 nuclear localization. This gene is expressed in the brain or in neuronal tissue. An allelic variant encoding amino acid Lys at 915, instead of conserved Glu, has been identified in patients with mild intellectual disability. [provided by RefSeq, Jan 2014].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| minichromosome maintenance complex component 3 associated protein | MIM:603294 | Ensembl:ENSG00000160294 | HGNC:HGNC:6946 | PA30692 | 21q22.3 |
GO terms in MCM3AP
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0003676 | nucleic acid binding |
| MF | IEA | GO:0016746 | transferase activity, transferring acyl groups |
| CC | HDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005634 | nucleus |
| CC | IEA | GO:0005643 | nuclear pore |
| CC | IEA | GO:0005654 | nucleoplasm |
| CC | HDA | GO:0005829 | cytosol |
| CC | IDA | GO:0005829 | cytosol |
| CC | IDA | GO:0031965 | nuclear membrane |
| BP | IEA | GO:0002376 | immune system process |
| BP | IEA | GO:0015031 | protein transport |
| BP | IEA | GO:0051028 | mRNA transport |
Gene expression in normal tissue: MCM3AP
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in MCM3AP
| Database | Pathway ID | Pathway Des. |
|---|
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD886 | Compound 1541A | 2 |
| iGMDRD60 | Quinoclamine | 3 |
| iGMDRD147 | Prima-1 | 2 |
| iGMDRD23 | Gossypol | 2 |
| iGMDRD356 | PNU-74654 | 2 |
| iGMDRD598 | QS-11 | 2 |
| iGMDRD414 | MST-312 | 3 |
| iGMDRD286 | Nsc 632839 | 4 |
| iGMDRD887 | Compound 23 citrate | 5 |
| iGMDRD289 | Parthenolide | 2 |
| iGMDRD705 | Nakiterpiosin | 5 |
| iGMDRD870 | BRD63610 | 4 |
| iGMDRD187 | BRD9876 | 2 |
| iGMDRD121 | GMX1778 | 2 |
| iGMDRD251 | ML162 | 2 |
| iGMDRD280 | CYTOCHALASIN B | 4 |
| iGMDRD679 | Bistramide A | 2 |
| iGMDRD154 | NSC23766 | 2 |
| iGMDRD61 | Kinetin riboside | 3 |
| iGMDRD152 | 179324-69-7 | 6 |
| iGMDRD427 | ABT737 | 3 |
| iGMDRD494 | Neopeltolide | 1 |
| iGMDRD484 | Pluripotin | 4 |
| iGMDRD79 | Gemcitabine | 2 |
| iGMDRD781 | Sirolimus | 2 |
| iGMDRD126 | Tipifarnib | 4 |
| iGMDRD607 | Ubistatin B | 2 |
| iGMDRD512 | nutlin 3 | 5 |
| iGMDRD420 | Leucascandrolide A | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in MCM3AP
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