MCM3AP


Summary: The minichromosome maintenance protein 3 (MCM3) is one of the MCM proteins essential for the initiation of DNA replication. The protein encoded by this gene is a MCM3 binding protein. It was reported to have phosphorylation-dependent DNA-primase activity, which was up-regulated in antigen immunization induced germinal center. This protein was demonstrated to be an acetyltransferase that acetylates MCM3 and plays a role in DNA replication. The mutagenesis of a nuclear localization signal of MCM3 affects the binding of this protein with MCM3, suggesting that this protein may also facilitate MCM3 nuclear localization. This gene is expressed in the brain or in neuronal tissue. An allelic variant encoding amino acid Lys at 915, instead of conserved Glu, has been identified in patients with mild intellectual disability. [provided by RefSeq, Jan 2014].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
minichromosome maintenance complex component 3 associated proteinMIM:603294Ensembl:ENSG00000160294HGNC:HGNC:6946PA3069221q22.3

GO terms in MCM3AP


Term TypeEvidence TypeGO Term IDGO Des.
MFIEAGO:0003676nucleic acid binding
MFIEAGO:0016746transferase activity, transferring acyl groups
CCHDAGO:0005634nucleus
CCIDAGO:0005634nucleus
CCIEAGO:0005643nuclear pore
CCIEAGO:0005654nucleoplasm
CCHDAGO:0005829cytosol
CCIDAGO:0005829cytosol
CCIDAGO:0031965nuclear membrane
BPIEAGO:0002376immune system process
BPIEAGO:0015031protein transport
BPIEAGO:0051028mRNA transport

Gene expression in normal tissue: MCM3AP

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in MCM3AP


DatabasePathway IDPathway Des.

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD886Compound 1541A2
iGMDRD60Quinoclamine3
iGMDRD147Prima-12
iGMDRD23Gossypol2
iGMDRD356PNU-746542
iGMDRD598QS-112
iGMDRD414MST-3123
iGMDRD286Nsc 6328394
iGMDRD887Compound 23 citrate5
iGMDRD289Parthenolide2
iGMDRD705Nakiterpiosin5
iGMDRD870BRD636104
iGMDRD187BRD98762
iGMDRD121GMX17782
iGMDRD251ML1622
iGMDRD280CYTOCHALASIN B4
iGMDRD679Bistramide A2
iGMDRD154NSC237662
iGMDRD61Kinetin riboside3
iGMDRD152179324-69-76
iGMDRD427ABT7373
iGMDRD494Neopeltolide1
iGMDRD484Pluripotin4
iGMDRD79Gemcitabine2
iGMDRD781Sirolimus2
iGMDRD126Tipifarnib4
iGMDRD607Ubistatin B2
iGMDRD512nutlin 35
iGMDRD420Leucascandrolide A2

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in MCM3AP

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