CSNK1G3
Summary: This gene encodes a member of a family of serine/threonine protein kinases that phosphorylate caseins and other acidic proteins. A related protein in the African clawed frog participates in the transmission of Wnt/beta-catenin signaling. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| casein kinase 1 gamma 3 | MIM:604253 | Ensembl:ENSG00000151292 | HGNC:HGNC:2456 | PA26956 | 5q23.2 |
GO terms in CSNK1G3
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IBA | GO:0005634 | nucleus |
| CC | IBA | GO:0005737 | cytoplasm |
| BP | TAS | GO:0006464 | cellular protein modification process |
| BP | IBA | GO:0006897 | endocytosis |
| BP | TAS | GO:0007165 | signal transduction |
| BP | IBA | GO:0018105 | peptidyl-serine phosphorylation |
| BP | IDA | GO:0018105 | peptidyl-serine phosphorylation |
| MF | TAS | GO:0004672 | protein kinase activity |
| MF | IBA | GO:0004674 | protein serine/threonine kinase activity |
| MF | IDA | GO:0004674 | protein serine/threonine kinase activity |
| MF | IEA | GO:0005524 | ATP binding |
Gene expression in normal tissue: CSNK1G3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CSNK1G3
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa04340 | Hedgehog signaling pathway - Homo sapiens (human) |
| pid | foxopathway | FoxO family signaling |
| pid | hedgehog_glipathway | Hedgehog signaling events mediated by Gli proteins |
| pid | p53regulationpathway | p53 pathway |
| wikipathways | WP4249 | Hedgehog Signaling Pathway |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD560 | MK-2206 | 6 |
| iGMDRD424 | Tamatinib | 2 |
| iGMDRD330 | BRD4132 | 3 |
| iGMDRD248 | BRD4354 | 5 |
| iGMDRD341 | Triacsin c | 2 |
| iGMDRD6 | AM-580 | 3 |
| iGMDRD434 | BMS-536924 | 3 |
| iGMDRD481 | Dactolisib | 3 |
| iGMDRD231 | Importazole | 2 |
| iGMDRD271 | Brefeldin A | 3 |
| iGMDRD202 | Curcumin | 2 |
| iGMDRD246 | NPC26 | 2 |
| iGMDRD82 | Quiflapon | 3 |
| iGMDRD42 | Vorinostat | 2 |
| iGMDRD286 | Nsc 632839 | 2 |
| iGMDRD871 | BRD6368 | 3 |
| iGMDRD366 | PI-103 | 2 |
| iGMDRD144 | NSC95397 | 2 |
| iGMDRD427 | ABT737 | 3 |
| iGMDRD494 | Neopeltolide | 5 |
| iGMDRD781 | Sirolimus | 3 |
| iGMDRD126 | Tipifarnib | 1 |
| iGMDRD554 | CHEMBL1434137 | 1 |
| iGMDRD599 | Salermide | 3 |
| iGMDRD889 | Compound 7d-cis | 2 |
| iGMDRD387 | CHIR-99021 | 4 |
| iGMDRD420 | Leucascandrolide A | 4 |
| iGMDRD679 | Bistramide A | 2 |
| iGMDRD718 | Pyrvinium pamoate | 3 |
| iGMDRD782 | DC-45-A2 | 3 |
| iGMDRD885 | Compound 110 | 2 |
| iGMDRD441 | TW 37 | 1 |
| iGMDRD870 | BRD63610 | 3 |
| iGMDRD52 | Rotenone | 6 |
| iGMDRD270 | Ciclosporin | 2 |
| iGMDRD255 | SB225002 | 3 |
| iGMDRD23 | Gossypol | 6 |
| iGMDRD524 | ISX-9 | 5 |
| iGMDRD188 | Piperlongumine | 5 |
| iGMDRD399 | Selumetinib | 3 |
| iGMDRD577 | BIX01294 | 7 |
| iGMDRD506 | Fedratinib | 2 |
| iGMDRD888 | Compound 44 | 5 |
| iGMDRD562 | Navitoclax | 9 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CSNK1G3
CLASSFICATION
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