CSNK1G3

Summary: This gene encodes a member of a family of serine/threonine protein kinases that phosphorylate caseins and other acidic proteins. A related protein in the African clawed frog participates in the transmission of Wnt/beta-catenin signaling. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Namecasein kinase 1 gamma 3
OMIM IDMIM:604253
Ensembl IDEnsembl:ENSG00000151292
HGNC IDHGNC:HGNC:2456
PHARMGKB IDPA26956
Map Location5q23.2

GO terms in CSNK1G3


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Term Type
Evidence Type
GO Term ID
GO Des.
CC IBA GO:0005634 nucleus
CC IBA GO:0005737 cytoplasm
BP TAS GO:0006464 cellular protein modification process
BP IBA GO:0006897 endocytosis
BP TAS GO:0007165 signal transduction
BP IBA GO:0018105 peptidyl-serine phosphorylation
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Gene expression in normal tissue: CSNK1G3

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

undefined30PI3K/MTOR signaling3Biosynthesis of secondary metabolites2Apoptosis regulation2ERK MAPK signaling1Other, kinases1Th17 cell differentiation1WNT signaling1Stilbenoid, diarylheptanoid and gingerol biosynthesis1Chromatin histone acetylation1

Pathways in CSNK1G3


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Database
Pathway ID
Pathway Des.
kegg hsa04340 Hedgehog signaling pathway - Homo sapiens (human)
pid foxopathway FoxO family signaling
pid hedgehog_glipathway Hedgehog signaling events mediated by Gli proteins
pid p53regulationpathway p53 pathway
wikipathways WP4249 Hedgehog Signaling Pathway
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD560 MK-2206 6
iGMDRD424 Tamatinib 2
iGMDRD330 BRD4132 3
iGMDRD248 BRD4354 5
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CSNK1G3

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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