LIFR
Summary: This gene encodes a protein that belongs to the type I cytokine receptor family. This protein combines with a high-affinity converter subunit, gp130, to form a receptor complex that mediates the action of the leukemia inhibitory factor, a polyfunctional cytokine that is involved in cellular differentiation, proliferation and survival in the adult and the embryo. Mutations in this gene cause Schwartz-Jampel syndrome type 2, a disease belonging to the group of the bent-bone dysplasias. A translocation that involves the promoter of this gene, t(5;8)(p13;q12) with the pleiomorphic adenoma gene 1, is associated with salivary gland pleiomorphic adenoma, a common type of benign epithelial tumor of the salivary gland. Multiple splice variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jun 2018].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| LIF receptor alpha | MIM:151443 | Ensembl:ENSG00000113594 | HGNC:HGNC:6597 | PA30371 | 5p13.1 |
Gene Categories:
DRUGGABLE GENOMEGO terms in LIFR
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0004896 | cytokine receptor activity |
| MF | IDA | GO:0004897 | ciliary neurotrophic factor receptor activity |
| MF | IBA | GO:0004923 | leukemia inhibitory factor receptor activity |
| MF | IDA | GO:0004923 | leukemia inhibitory factor receptor activity |
| MF | IDA | GO:0004923 | leukemia inhibitory factor receptor activity |
| MF | IBA | GO:0004924 | oncostatin-M receptor activity |
| MF | IDA | GO:0004924 | oncostatin-M receptor activity |
| MF | IBA | GO:0005127 | ciliary neurotrophic factor receptor binding |
| MF | IPI | GO:0005127 | ciliary neurotrophic factor receptor binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IPI | GO:0019838 | growth factor binding |
| MF | IBA | GO:0019955 | cytokine binding |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005887 | integral component of plasma membrane |
| CC | IBA | GO:0009897 | external side of plasma membrane |
| CC | IBA | GO:0043235 | receptor complex |
| CC | IDA | GO:0043235 | receptor complex |
| CC | HDA | GO:0070062 | extracellular exosome |
| BP | TAS | GO:0001959 | regulation of cytokine-mediated signaling pathway |
| BP | TAS | GO:0007166 | cell surface receptor signaling pathway |
| BP | IBA | GO:0008284 | positive regulation of cell proliferation |
| BP | IDA | GO:0008284 | positive regulation of cell proliferation |
| BP | IDA | GO:0019221 | cytokine-mediated signaling pathway |
| BP | TAS | GO:0019221 | cytokine-mediated signaling pathway |
| BP | IDA | GO:0034097 | response to cytokine |
| BP | IMP | GO:0038165 | oncostatin-M-mediated signaling pathway |
| BP | IDA | GO:0048861 | leukemia inhibitory factor signaling pathway |
| BP | IDA | GO:0070120 | ciliary neurotrophic factor-mediated signaling pathway |
Gene expression in normal tissue: LIFR
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in LIFR
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP1528 | Physiological and Pathological Hypertrophy of the Heart |
| wikipathways | WP236 | Adipogenesis |
| wikipathways | WP2374 | Oncostatin M Signaling Pathway |
| wikipathways | WP3931 | ESC Pluripotency Pathways |
| wikipathways | WP4105 | Transcriptional regulation by RUNX1 |
| kegg | hsa04060 | Cytokine-cytokine receptor interaction - Homo sapiens (human) |
| kegg | hsa04550 | Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human) |
| kegg | hsa04630 | Jak-STAT signaling pathway - Homo sapiens (human) |
| netpath | Pathway_Oncostatin_M | Oncostatin_M |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-449147 | Signaling by Interleukins |
| reactome | R-HSA-6783589 | Interleukin-6 family signaling |
| reactome | R-HSA-6788467 | IL-6-type cytokine receptor ligand interactions |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-8878171 | Transcriptional regulation by RUNX1 |
| reactome | R-HSA-8939247 | RUNX1 regulates transcription of genes involved in interleukin signaling |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD446 | LY 2183240 | 1 |
| iGMDRD193 | Fqi1 | 4 |
| iGMDRD280 | CYTOCHALASIN B | 5 |
| iGMDRD433 | Lexibulin | 1 |
| iGMDRD151 | CHM-1 | 3 |
| iGMDRD599 | Salermide | 4 |
| iGMDRD420 | Leucascandrolide A | 3 |
| iGMDRD779 | PRL-3 Inhibitor I | 1 |
| iGMDRD483 | SCH-529074 | 2 |
| iGMDRD494 | Neopeltolide | 1 |
| iGMDRD781 | Sirolimus | 1 |
| iGMDRD188 | Piperlongumine | 6 |
| iGMDRD100 | Zebularine | 7 |
| iGMDRD399 | Selumetinib | 3 |
| iGMDRD887 | Compound 23 citrate | 2 |
| iGMDRD506 | Fedratinib | 2 |
| iGMDRD888 | Compound 44 | 3 |
| iGMDRD780 | PP-30 | 1 |
| iGMDRD64 | Parbendazole | 6 |
| iGMDRD356 | PNU-74654 | 1 |
| iGMDRD138 | PX 12 | 2 |
| iGMDRD260 | FQI-2 | 3 |
| iGMDRD255 | SB225002 | 1 |
| iGMDRD802 | 4-methylfasudil | 3 |
| iGMDRD171 | Pemetrexed | 2 |
| iGMDRD318 | PAC-1 | 1 |
| iGMDRD187 | BRD9876 | 6 |
| iGMDRD341 | Triacsin c | 3 |
| iGMDRD85 | Ursolic acid | 3 |
| iGMDRD536 | PLX-4720 | 1 |
| iGMDRD57 | Chloropentafluorobenzene | 4 |
| iGMDRD901 | ELCPK | 3 |
| iGMDRD123 | Isoevodiamine | 3 |
| iGMDRD154 | NSC23766 | 6 |
| iGMDRD945 | ML214 | 2 |
| iGMDRD150 | RITA | 3 |
| iGMDRD424 | Tamatinib | 2 |
| iGMDRD405 | PIK-75 | 2 |
| iGMDRD79 | Gemcitabine | 2 |
| iGMDRD872 | BRD7137 | 3 |
| iGMDRD329 | Merck60 | 6 |
| iGMDRD662 | JQ-1 | 2 |
| iGMDRD505 | Pevonedistat | 2 |
| iGMDRD246 | NPC26 | 2 |
| iGMDRD158 | NSC141540 | 4 |
| iGMDRD705 | Nakiterpiosin | 3 |
| iGMDRD6 | AM-580 | 2 |
| iGMDRD289 | Parthenolide | 3 |
| iGMDRD77 | Itraconazole | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in LIFR
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