HNRNPH1


Summary: This gene encodes a member of a subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins that complex with heterogeneous nuclear RNA. These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some may shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has three repeats of quasi-RRM domains that bind to RNA and is very similar to the family member HNRPF. This gene may be associated with hereditary lymphedema type I. Alternatively spliced transcript variants have been described [provided by RefSeq, Mar 2012].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
heterogeneous nuclear ribonucleoprotein H1MIM:601035Ensembl:ENSG00000169045HGNC:HGNC:5041PA1623912845q35.3

GO terms in HNRNPH1


Term TypeEvidence TypeGO Term IDGO Des.
BPICGO:0000398mRNA splicing, via spliceosome
BPTASGO:0000398mRNA splicing, via spliceosome
BPTASGO:0006396RNA processing
BPTASGO:0008543fibroblast growth factor receptor signaling pathway
BPTASGO:0016070RNA metabolic process
BPIDAGO:0043484regulation of RNA splicing
CCIDAGO:0005634nucleus
CCIDAGO:0005654nucleoplasm
CCTASGO:0005654nucleoplasm
CCIDAGO:0005829cytosol
CCHDAGO:0016020membrane
CCIDAGO:0071013catalytic step 2 spliceosome
MFHDAGO:0003723RNA binding
MFIDAGO:0003723RNA binding
MFIPIGO:0005515protein binding
MFTASGO:0008266poly(U) RNA binding

Gene expression in normal tissue: HNRNPH1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in HNRNPH1


DatabasePathway IDPathway Des.
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-190236Signaling by FGFR
reactomeR-HSA-5654738Signaling by FGFR2
reactomeR-HSA-6803529FGFR2 alternative splicing
reactomeR-HSA-72163mRNA Splicing - Major Pathway
reactomeR-HSA-72172mRNA Splicing
reactomeR-HSA-72203Processing of Capped Intron-Containing Pre-mRNA
reactomeR-HSA-8953854Metabolism of RNA
reactomeR-HSA-9006934Signaling by Receptor Tyrosine Kinases
wikipathwaysWP3584MECP2 and Associated Rett Syndrome
wikipathwaysWP411mRNA Processing

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD82Quiflapon1
iGMDRD886Compound 1541A2
iGMDRD300Tozasertib3
iGMDRD329Merck603
iGMDRD871BRD63682
iGMDRD6AM-5802
iGMDRD202Curcumin1
iGMDRD121GMX17783
iGMDRD211(1S,3R)-RSL32
iGMDRD57Chloropentafluorobenzene2
iGMDRD61Kinetin riboside4
iGMDRD152179324-69-74
iGMDRD446LY 21832401
iGMDRD781Sirolimus2
iGMDRD560MK-22062
iGMDRD670ML 2102
iGMDRD512nutlin 34
iGMDRD420Leucascandrolide A3
iGMDRD84Lovastatin acid2

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in HNRNPH1

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