BMP4


Summary: This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein regulates heart development and adipogenesis. Mutations in this gene are associated with orofacial cleft and microphthalmia in human patients. The encoded protein may also be involved in the pathology of multiple cardiovascular diseases and human cancers. [provided by RefSeq, Jul 2016].

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GO terms in BMP4


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IBA GO:0005125 cytokine activity
MF IDA GO:0005125 cytokine activity
MF IBA GO:0005160 transforming growth factor beta receptor binding
MF IPI GO:0005515 protein binding
MF IEA GO:0008083 growth factor activity
MF IEA GO:0008201 heparin binding
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Gene expression in normal tissue: BMP4

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

undefined35Apoptosis regulation3Biosynthesis of secondary metabolites1IGFR signaling1Longevity regulating pathway1Proteasome1Other, kinases1Arachidonic acid metabolism1Cell cycle1Genome integrity1

Pathways in BMP4


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Database
Pathway ID
Pathway Des.
wikipathways WP1591 Heart Development
wikipathways WP2064 Neural Crest Differentiation
wikipathways WP236 Adipogenesis
wikipathways WP2406 Cardiac Progenitor Differentiation
wikipathways WP2804 Hair Follicle Development- Induction (Part 1 of 3)
wikipathways WP2848 Differentiation Pathway
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD237 ABT-751 3
iGMDRD219 Bax channel blocker 3
iGMDRD351 GW843682X 3
iGMDRD945 ML214 3
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in BMP4

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
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No matching records found

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