BMP4
Summary: This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein regulates heart development and adipogenesis. Mutations in this gene are associated with orofacial cleft and microphthalmia in human patients. The encoded protein may also be involved in the pathology of multiple cardiovascular diseases and human cancers. [provided by RefSeq, Jul 2016].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
OMIM IDMIM:112262 Ensembl IDEnsembl:ENSG00000125378 HGNC IDHGNC:HGNC:1071 PHARMGKB IDPA25381 Map Location14q22.2 |
GO terms in BMP4
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Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
MF | IBA | GO:0005125 | cytokine activity |
MF | IDA | GO:0005125 | cytokine activity |
MF | IBA | GO:0005160 | transforming growth factor beta receptor binding |
MF | IPI | GO:0005515 | protein binding |
MF | IEA | GO:0008083 | growth factor activity |
MF | IEA | GO:0008201 | heparin binding |
Gene expression in normal tissue: BMP4
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in BMP4
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Database | Pathway ID | Pathway Des. |
---|---|---|
wikipathways | WP1591 | Heart Development |
wikipathways | WP2064 | Neural Crest Differentiation |
wikipathways | WP236 | Adipogenesis |
wikipathways | WP2406 | Cardiac Progenitor Differentiation |
wikipathways | WP2804 | Hair Follicle Development- Induction (Part 1 of 3) |
wikipathways | WP2848 | Differentiation Pathway |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot

Gene-drug targets distribution
Gene Structure: PDB
Models in BMP4
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
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No matching records found |