BMP4
Summary: This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein regulates heart development and adipogenesis. Mutations in this gene are associated with orofacial cleft and microphthalmia in human patients. The encoded protein may also be involved in the pathology of multiple cardiovascular diseases and human cancers. [provided by RefSeq, Jul 2016].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| bone morphogenetic protein 4 | MIM:112262 | Ensembl:ENSG00000125378 | HGNC:HGNC:1071 | PA25381 | 14q22.2 |
GO terms in BMP4
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0005125 | cytokine activity |
| MF | IDA | GO:0005125 | cytokine activity |
| MF | IBA | GO:0005160 | transforming growth factor beta receptor binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0008083 | growth factor activity |
| MF | IEA | GO:0008201 | heparin binding |
| MF | IPI | GO:0039706 | co-receptor binding |
| MF | IDA | GO:0042056 | chemoattractant activity |
| MF | IBA | GO:0070700 | BMP receptor binding |
| MF | IDA | GO:0070700 | BMP receptor binding |
| BP | IBA | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | IDA | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | ISS | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | IDA | GO:0000186 | activation of MAPKK activity |
| BP | IDA | GO:0001649 | osteoblast differentiation |
| BP | IDA | GO:0001657 | ureteric bud development |
| BP | IDA | GO:0001658 | branching involved in ureteric bud morphogenesis |
| BP | IMP | GO:0001822 | kidney development |
| BP | IEP | GO:0001823 | mesonephros development |
| BP | IEA | GO:0001843 | neural tube closure |
| BP | IDA | GO:0001934 | positive regulation of protein phosphorylation |
| BP | IDA | GO:0001938 | positive regulation of endothelial cell proliferation |
| BP | ISS | GO:0001958 | endochondral ossification |
| BP | IDA | GO:0002043 | blood vessel endothelial cell proliferation involved in sprouting angiogenesis |
| BP | ISS | GO:0002062 | chondrocyte differentiation |
| BP | IDA | GO:0002244 | hematopoietic progenitor cell differentiation |
| BP | IMP | GO:0002320 | lymphoid progenitor cell differentiation |
| BP | IEA | GO:0003014 | renal system process |
| BP | IMP | GO:0003130 | BMP signaling pathway involved in heart induction |
| BP | IMP | GO:0003139 | secondary heart field specification |
| BP | ISS | GO:0003148 | outflow tract septum morphogenesis |
| BP | ISS | GO:0003149 | membranous septum morphogenesis |
| BP | ISS | GO:0003150 | muscular septum morphogenesis |
| BP | ISS | GO:0003180 | aortic valve morphogenesis |
| BP | ISS | GO:0003184 | pulmonary valve morphogenesis |
| BP | ISS | GO:0003197 | endocardial cushion development |
| BP | ISS | GO:0003198 | epithelial to mesenchymal transition involved in endocardial cushion formation |
| BP | ISS | GO:0003215 | cardiac right ventricle morphogenesis |
| BP | ISS | GO:0003277 | apoptotic process involved in endocardial cushion morphogenesis |
| BP | TAS | GO:0003279 | cardiac septum development |
| BP | IDA | GO:0003323 | type B pancreatic cell development |
| BP | IDA | GO:0003337 | mesenchymal to epithelial transition involved in metanephros morphogenesis |
| BP | IDA | GO:0007182 | common-partner SMAD protein phosphorylation |
| BP | IEP | GO:0007224 | smoothened signaling pathway |
| BP | IEA | GO:0007281 | germ cell development |
| BP | IEA | GO:0007492 | endoderm development |
| BP | IEA | GO:0007500 | mesodermal cell fate determination |
| BP | IDA | GO:0008284 | positive regulation of cell proliferation |
| BP | IDA | GO:0008285 | negative regulation of cell proliferation |
| BP | IDA | GO:0009791 | post-embryonic development |
| BP | IEA | GO:0009948 | anterior/posterior axis specification |
| BP | IEA | GO:0010159 | specification of animal organ position |
| BP | IDA | GO:0010453 | regulation of cell fate commitment |
| BP | IEA | GO:0010469 | regulation of signaling receptor activity |
| BP | IDA | GO:0010595 | positive regulation of endothelial cell migration |
| BP | IDA | GO:0010628 | positive regulation of gene expression |
| BP | IDA | GO:0010629 | negative regulation of gene expression |
| BP | IEA | GO:0010718 | positive regulation of epithelial to mesenchymal transition |
| BP | IBA | GO:0010862 | positive regulation of pathway-restricted SMAD protein phosphorylation |
| BP | IDA | GO:0010862 | positive regulation of pathway-restricted SMAD protein phosphorylation |
| BP | IMP | GO:0010862 | positive regulation of pathway-restricted SMAD protein phosphorylation |
| BP | IDA | GO:0010942 | positive regulation of cell death |
| BP | IDA | GO:0021537 | telencephalon development |
| BP | IEA | GO:0021904 | dorsal/ventral neural tube patterning |
| BP | IEA | GO:0021978 | telencephalon regionalization |
| BP | IEA | GO:0021983 | pituitary gland development |
| BP | IEA | GO:0030218 | erythrocyte differentiation |
| BP | IDA | GO:0030224 | monocyte differentiation |
| BP | IDA | GO:0030225 | macrophage differentiation |
| BP | IDA | GO:0030501 | positive regulation of bone mineralization |
| BP | IBA | GO:0030509 | BMP signaling pathway |
| BP | IDA | GO:0030509 | BMP signaling pathway |
| BP | IMP | GO:0030509 | BMP signaling pathway |
| BP | ISS | GO:0030513 | positive regulation of BMP signaling pathway |
| BP | IDA | GO:0032092 | positive regulation of protein binding |
| BP | IEA | GO:0032331 | negative regulation of chondrocyte differentiation |
| BP | IDA | GO:0032967 | positive regulation of collagen biosynthetic process |
| BP | IMP | GO:0033085 | negative regulation of T cell differentiation in thymus |
| BP | IMP | GO:0033088 | negative regulation of immature T cell proliferation in thymus |
| BP | IDA | GO:0034504 | protein localization to nucleus |
| BP | IEA | GO:0035116 | embryonic hindlimb morphogenesis |
| BP | ISS | GO:0035990 | tendon cell differentiation |
| BP | ISS | GO:0035993 | deltoid tuberosity development |
| BP | IDA | GO:0042306 | regulation of protein import into nucleus |
| BP | IDA | GO:0042326 | negative regulation of phosphorylation |
| BP | IEA | GO:0042475 | odontogenesis of dentin-containing tooth |
| BP | IGI | GO:0042476 | odontogenesis |
| BP | IEA | GO:0042487 | regulation of odontogenesis of dentin-containing tooth |
| BP | IEA | GO:0042733 | embryonic digit morphogenesis |
| BP | IBA | GO:0042981 | regulation of apoptotic process |
| BP | IDA | GO:0043065 | positive regulation of apoptotic process |
| BP | IBA | GO:0043066 | negative regulation of apoptotic process |
| BP | IDA | GO:0043066 | negative regulation of apoptotic process |
| BP | IMP | GO:0043401 | steroid hormone mediated signaling pathway |
| BP | IDA | GO:0043407 | negative regulation of MAP kinase activity |
| BP | IBA | GO:0043408 | regulation of MAPK cascade |
| BP | TAS | GO:0043687 | post-translational protein modification |
| BP | TAS | GO:0044267 | cellular protein metabolic process |
| BP | IEA | GO:0045603 | positive regulation of endothelial cell differentiation |
| BP | IDA | GO:0045606 | positive regulation of epidermal cell differentiation |
| BP | IDA | GO:0045662 | negative regulation of myoblast differentiation |
| BP | IEA | GO:0045666 | positive regulation of neuron differentiation |
| BP | IDA | GO:0045669 | positive regulation of osteoblast differentiation |
| BP | IDA | GO:0045778 | positive regulation of ossification |
| BP | IDA | GO:0045786 | negative regulation of cell cycle |
| BP | IDA | GO:0045839 | negative regulation of mitotic nuclear division |
| BP | IDA | GO:0045843 | negative regulation of striated muscle tissue development |
| BP | IDA | GO:0045892 | negative regulation of transcription, DNA-templated |
| BP | IDA | GO:0045893 | positive regulation of transcription, DNA-templated |
| BP | IDA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IGI | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | ISS | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IDA | GO:0048286 | lung alveolus development |
| BP | IDA | GO:0048392 | intermediate mesodermal cell differentiation |
| BP | IBA | GO:0048468 | cell development |
| BP | IDA | GO:0048661 | positive regulation of smooth muscle cell proliferation |
| BP | IEA | GO:0048663 | neuron fate commitment |
| BP | IEA | GO:0048701 | embryonic cranial skeleton morphogenesis |
| BP | ISS | GO:0048745 | smooth muscle tissue development |
| BP | IDA | GO:0048754 | branching morphogenesis of an epithelial tube |
| BP | IDA | GO:0050679 | positive regulation of epithelial cell proliferation |
| BP | IEA | GO:0050680 | negative regulation of epithelial cell proliferation |
| BP | IEA | GO:0050918 | positive chemotaxis |
| BP | IEA | GO:0051150 | regulation of smooth muscle cell differentiation |
| BP | IEA | GO:0055007 | cardiac muscle cell differentiation |
| BP | IMP | GO:0055020 | positive regulation of cardiac muscle fiber development |
| BP | IEA | GO:0060113 | inner ear receptor cell differentiation |
| BP | IEA | GO:0060197 | cloacal septation |
| BP | IEA | GO:0060235 | lens induction in camera-type eye |
| BP | IEA | GO:0060272 | embryonic skeletal joint morphogenesis |
| BP | IEA | GO:0060363 | cranial suture morphogenesis |
| BP | IDA | GO:0060391 | positive regulation of SMAD protein signal transduction |
| BP | IDA | GO:0060393 | regulation of pathway-restricted SMAD protein phosphorylation |
| BP | IBA | GO:0060395 | SMAD protein signal transduction |
| BP | IDA | GO:0060395 | SMAD protein signal transduction |
| BP | IDA | GO:0060425 | lung morphogenesis |
| BP | IDA | GO:0060433 | bronchus development |
| BP | IDA | GO:0060438 | trachea development |
| BP | IEA | GO:0060440 | trachea formation |
| BP | IDA | GO:0060441 | epithelial tube branching involved in lung morphogenesis |
| BP | IEA | GO:0060442 | branching involved in prostate gland morphogenesis |
| BP | IEA | GO:0060449 | bud elongation involved in lung branching |
| BP | IDA | GO:0060502 | epithelial cell proliferation involved in lung morphogenesis |
| BP | IDA | GO:0060503 | bud dilation involved in lung branching |
| BP | IDA | GO:0060548 | negative regulation of cell death |
| BP | IEA | GO:0060592 | mammary gland formation |
| BP | IEA | GO:0060684 | epithelial-mesenchymal cell signaling |
| BP | IEA | GO:0060686 | negative regulation of prostatic bud formation |
| BP | IEA | GO:0060687 | regulation of branching involved in prostate gland morphogenesis |
| BP | ISS | GO:0060976 | coronary vasculature development |
| BP | IDA | GO:0061036 | positive regulation of cartilage development |
| BP | ISS | GO:0061047 | positive regulation of branching involved in lung morphogenesis |
| BP | ISS | GO:0061149 | BMP signaling pathway involved in ureter morphogenesis |
| BP | ISS | GO:0061151 | BMP signaling pathway involved in renal system segmentation |
| BP | IDA | GO:0061155 | pulmonary artery endothelial tube morphogenesis |
| BP | ISS | GO:0061312 | BMP signaling pathway involved in heart development |
| BP | ISS | GO:0061626 | pharyngeal arch artery morphogenesis |
| BP | IMP | GO:0070244 | negative regulation of thymocyte apoptotic process |
| BP | IEA | GO:0070374 | positive regulation of ERK1 and ERK2 cascade |
| BP | IMP | GO:0071773 | cellular response to BMP stimulus |
| BP | IDA | GO:0071893 | BMP signaling pathway involved in nephric duct formation |
| BP | IEP | GO:0072001 | renal system development |
| BP | IEA | GO:0072015 | glomerular visceral epithelial cell development |
| BP | IDA | GO:0072097 | negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway |
| BP | IDA | GO:0072101 | specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway |
| BP | ISS | GO:0072104 | glomerular capillary formation |
| BP | IDA | GO:0072125 | negative regulation of glomerular mesangial cell proliferation |
| BP | IEA | GO:0072138 | mesenchymal cell proliferation involved in ureteric bud development |
| BP | IEA | GO:0072161 | mesenchymal cell differentiation involved in kidney development |
| BP | ISS | GO:0072192 | ureter epithelial cell differentiation |
| BP | ISS | GO:0072193 | ureter smooth muscle cell differentiation |
| BP | IEA | GO:0072198 | mesenchymal cell proliferation involved in ureter development |
| BP | IDA | GO:0072200 | negative regulation of mesenchymal cell proliferation involved in ureter development |
| BP | ISS | GO:0072205 | metanephric collecting duct development |
| BP | IDA | GO:0090184 | positive regulation of kidney development |
| BP | IDA | GO:0090191 | negative regulation of branching involved in ureteric bud morphogenesis |
| BP | IDA | GO:0090194 | negative regulation of glomerulus development |
| BP | ISS | GO:1901964 | positive regulation of cell proliferation involved in outflow tract morphogenesis |
| BP | IMP | GO:1902893 | regulation of pri-miRNA transcription by RNA polymerase II |
| BP | IDA | GO:1902894 | negative regulation of pri-miRNA transcription by RNA polymerase II |
| BP | IDA | GO:1903800 | positive regulation of production of miRNAs involved in gene silencing by miRNA |
| BP | ISS | GO:1905072 | cardiac jelly development |
| BP | IEA | GO:1905312 | positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis |
| BP | IDA | GO:2000005 | negative regulation of metanephric S-shaped body morphogenesis |
| BP | IDA | GO:2000007 | negative regulation of metanephric comma-shaped body morphogenesis |
| BP | IMP | GO:2000137 | negative regulation of cell proliferation involved in heart morphogenesis |
| BP | ISS | GO:2001237 | negative regulation of extrinsic apoptotic signaling pathway |
| CC | ISS | GO:0005576 | extracellular region |
| CC | TAS | GO:0005576 | extracellular region |
| CC | IBA | GO:0005615 | extracellular space |
| CC | IDA | GO:0005615 | extracellular space |
| CC | ISS | GO:0005615 | extracellular space |
| CC | TAS | GO:0005788 | endoplasmic reticulum lumen |
Gene expression in normal tissue: BMP4
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in BMP4
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP1591 | Heart Development |
| wikipathways | WP2064 | Neural Crest Differentiation |
| wikipathways | WP236 | Adipogenesis |
| wikipathways | WP2406 | Cardiac Progenitor Differentiation |
| wikipathways | WP2804 | Hair Follicle Development- Induction (Part 1 of 3) |
| wikipathways | WP2848 | Differentiation Pathway |
| wikipathways | WP2857 | Mesodermal Commitment Pathway |
| wikipathways | WP2858 | Ectoderm Differentiation |
| wikipathways | WP2895 | Differentiation of white and brown adipocyte |
| wikipathways | WP3927 | BMP Signaling Pathway in Eyelid Development |
| wikipathways | WP3931 | ESC Pluripotency Pathways |
| wikipathways | WP560 | TGF-beta Receptor Signaling |
| kegg | hsa04350 | TGF-beta signaling pathway - Homo sapiens (human) |
| kegg | hsa04390 | Hippo signaling pathway - Homo sapiens (human) |
| kegg | hsa04550 | Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human) |
| kegg | hsa04919 | Thyroid hormone signaling pathway - Homo sapiens (human) |
| kegg | hsa05200 | Pathways in cancer - Homo sapiens (human) |
| kegg | hsa05217 | Basal cell carcinoma - Homo sapiens (human) |
| kegg | hsa05418 | Fluid shear stress and atherosclerosis - Homo sapiens (human) |
| pid | bmppathway | BMP receptor signaling |
| biocarta | alkpathway | alk in cardiac myocytes |
| reactome | R-HSA-1474244 | Extracellular matrix organization |
| reactome | R-HSA-1566948 | Elastic fibre formation |
| reactome | R-HSA-2129379 | Molecules associated with elastic fibres |
| reactome | R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-597592 | Post-translational protein modification |
| reactome | R-HSA-8957275 | Post-translational protein phosphorylation |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD237 | ABT-751 | 3 |
| iGMDRD219 | Bax channel blocker | 3 |
| iGMDRD351 | GW843682X | 3 |
| iGMDRD945 | ML214 | 3 |
| iGMDRD132 | (-)-gallocatechin-3-O-gallate | 3 |
| iGMDRD84 | Lovastatin acid | 5 |
| iGMDRD148 | Pifithrin-mu | 3 |
| iGMDRD512 | nutlin 3 | 6 |
| iGMDRD607 | Ubistatin B | 1 |
| iGMDRD532 | Olaparib | 3 |
| iGMDRD79 | Gemcitabine | 3 |
| iGMDRD286 | Nsc 632839 | 5 |
| iGMDRD147 | Prima-1 | 1 |
| iGMDRD300 | Tozasertib | 8 |
| iGMDRD505 | Pevonedistat | 1 |
| iGMDRD121 | GMX1778 | 2 |
| iGMDRD137 | Indisulam | 3 |
| iGMDRD103 | SN-38 | 3 |
| iGMDRD5 | Tyrphostin AG 1478 | 2 |
| iGMDRD6 | AM-580 | 1 |
| iGMDRD107 | Valdecoxib | 3 |
| iGMDRD71 | Sparfosic acid | 2 |
| iGMDRD446 | LY 2183240 | 3 |
| iGMDRD61 | Kinetin riboside | 2 |
| iGMDRD152 | 179324-69-7 | 2 |
| iGMDRD466 | Chaetocin | 2 |
| iGMDRD375 | GW-405833 | 3 |
| iGMDRD210 | AC55649 | 1 |
| iGMDRD554 | CHEMBL1434137 | 3 |
| iGMDRD126 | Tipifarnib | 5 |
| iGMDRD420 | Leucascandrolide A | 2 |
| iGMDRD772 | BRD4770 | 2 |
| iGMDRD579 | PF750 | 2 |
| iGMDRD779 | PRL-3 Inhibitor I | 3 |
| iGMDRD546 | BMS-754807 | 2 |
| iGMDRD781 | Sirolimus | 5 |
| iGMDRD494 | Neopeltolide | 3 |
| iGMDRD483 | SCH-529074 | 3 |
| iGMDRD887 | Compound 23 citrate | 4 |
| iGMDRD188 | Piperlongumine | 3 |
| iGMDRD398 | Sepantronium | 2 |
| iGMDRD506 | Fedratinib | 2 |
| iGMDRD369 | TGX-115 | 5 |
| iGMDRD64 | Parbendazole | 3 |
| iGMDRD23 | Gossypol | 3 |
| iGMDRD356 | PNU-74654 | 3 |
| iGMDRD870 | BRD63610 | 5 |
| iGMDRD441 | TW 37 | 1 |
| iGMDRD318 | PAC-1 | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in BMP4
CLASSFICATION
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