DACH1
Summary: This gene encodes a chromatin-associated protein that associates with other DNA-binding transcription factors to regulate gene expression and cell fate determination during development. The protein contains a Ski domain that is highly conserved from Drosophila to human. Expression of this gene is lost in some forms of metastatic cancer, and is correlated with poor prognosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| dachshund family transcription factor 1 | MIM:603803 | Ensembl:ENSG00000276644 | HGNC:HGNC:2663 | PA27134 | 13q21.33 |
GO terms in DACH1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0001075 | transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly |
| MF | IDA | GO:0001078 | transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding |
| MF | IEA | GO:0003677 | DNA binding |
| MF | IPI | GO:0005515 | protein binding |
| BP | IEA | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0001967 | suckling behavior |
| BP | IBA | GO:0006355 | regulation of transcription, DNA-templated |
| BP | IEA | GO:0007585 | respiratory gaseous exchange |
| BP | IEA | GO:0008283 | cell proliferation |
| BP | IMP | GO:0010944 | negative regulation of transcription by competitive promoter binding |
| BP | IDA | GO:0030336 | negative regulation of cell migration |
| BP | IEA | GO:0033262 | regulation of nuclear cell cycle DNA replication |
| BP | IMP | GO:0045892 | negative regulation of transcription, DNA-templated |
| BP | IEA | GO:0046545 | development of primary female sexual characteristics |
| BP | IEA | GO:0048147 | negative regulation of fibroblast proliferation |
| BP | IEA | GO:0051123 | RNA polymerase II transcriptional preinitiation complex assembly |
| BP | IEA | GO:0060244 | negative regulation of cell proliferation involved in contact inhibition |
| BP | IDA | GO:2000279 | negative regulation of DNA biosynthetic process |
| CC | IBA | GO:0005634 | nucleus |
| CC | IBA | GO:0005667 | transcription factor complex |
| CC | IEA | GO:0005737 | cytoplasm |
Gene expression in normal tissue: DACH1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in DACH1
| Database | Pathway ID | Pathway Des. |
|---|
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD466 | Chaetocin | 3 |
| iGMDRD193 | Fqi1 | 2 |
| iGMDRD446 | LY 2183240 | 1 |
| iGMDRD494 | Neopeltolide | 2 |
| iGMDRD405 | PIK-75 | 4 |
| iGMDRD781 | Sirolimus | 4 |
| iGMDRD560 | MK-2206 | 3 |
| iGMDRD512 | nutlin 3 | 5 |
| iGMDRD1008 | SR-II-138A | 2 |
| iGMDRD420 | Leucascandrolide A | 5 |
| iGMDRD322 | FK 866 | 3 |
| iGMDRD886 | Compound 1541A | 3 |
| iGMDRD369 | TGX-115 | 2 |
| iGMDRD64 | Parbendazole | 2 |
| iGMDRD871 | BRD6368 | 2 |
| iGMDRD367 | Ro 28-1675 | 2 |
| iGMDRD872 | BRD7137 | 2 |
| iGMDRD730 | Kahalalide F | 3 |
| iGMDRD870 | BRD63610 | 5 |
| iGMDRD289 | Parthenolide | 2 |
| iGMDRD255 | SB225002 | 2 |
| iGMDRD103 | SN-38 | 3 |
| iGMDRD121 | GMX1778 | 3 |
| iGMDRD137 | Indisulam | 4 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in DACH1
CLASSFICATION
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