GRK4
Summary: This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating its deactivation. This gene has been linked to both genetic and acquired hypertension. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| G protein-coupled receptor kinase 4 | MIM:137026 | Ensembl:ENSG00000125388 | HGNC:HGNC:4543 | PA28941 | 4p16.3 |
GO terms in GRK4
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IEA | GO:0002031 | G-protein coupled receptor internalization |
| BP | IEA | GO:0006468 | protein phosphorylation |
| BP | IEA | GO:0007165 | signal transduction |
| BP | TAS | GO:0008277 | regulation of G-protein coupled receptor protein signaling pathway |
| BP | TAS | GO:0022400 | regulation of rhodopsin mediated signaling pathway |
| BP | IDA | GO:0031623 | receptor internalization |
| CC | IEA | GO:0005829 | cytosol |
| CC | IEA | GO:0005938 | cell cortex |
| CC | IEA | GO:0030425 | dendrite |
| CC | IEA | GO:0043025 | neuronal cell body |
| CC | TAS | GO:0097381 | photoreceptor disc membrane |
| MF | IEA | GO:0004703 | G-protein coupled receptor kinase activity |
| MF | IEA | GO:0005524 | ATP binding |
| MF | TAS | GO:0050254 | rhodopsin kinase activity |
Gene expression in normal tissue: GRK4
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in GRK4
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa04062 | Chemokine signaling pathway - Homo sapiens (human) |
| kegg | hsa04144 | Endocytosis - Homo sapiens (human) |
| kegg | hsa05032 | Morphine addiction - Homo sapiens (human) |
| wikipathways | WP289 | Myometrial Relaxation and Contraction Pathways |
| wikipathways | WP3929 | Chemokine signaling pathway |
| wikipathways | WP536 | Calcium Regulation in the Cardiac Cell |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-2187338 | Visual phototransduction |
| reactome | R-HSA-2514856 | The phototransduction cascade |
| reactome | R-HSA-2514859 | Inactivation, recovery and regulation of the phototransduction cascade |
| reactome | R-HSA-372790 | Signaling by GPCR |
| reactome | R-HSA-388396 | GPCR downstream signalling |
| reactome | R-HSA-418594 | G alpha (i) signalling events |
| biocarta | agpcrpathway | attenuation of gpcr signaling |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD446 | LY 2183240 | 2 |
| iGMDRD85 | Ursolic acid | 2 |
| iGMDRD57 | Chloropentafluorobenzene | 3 |
| iGMDRD314 | Tanespimycin | 5 |
| iGMDRD61 | Kinetin riboside | 2 |
| iGMDRD193 | Fqi1 | 4 |
| iGMDRD297 | Austocystin D | 2 |
| iGMDRD466 | Chaetocin | 2 |
| iGMDRD132 | (-)-gallocatechin-3-O-gallate | 5 |
| iGMDRD409 | Saracatinib | 1 |
| iGMDRD1008 | SR-II-138A | 1 |
| iGMDRD420 | Leucascandrolide A | 2 |
| iGMDRD424 | Tamatinib | 6 |
| iGMDRD79 | Gemcitabine | 4 |
| iGMDRD652 | UNC0638 | 3 |
| iGMDRD286 | Nsc 632839 | 4 |
| iGMDRD872 | BRD7137 | 2 |
| iGMDRD562 | Navitoclax | 4 |
| iGMDRD60 | Quinoclamine | 2 |
| iGMDRD64 | Parbendazole | 4 |
| iGMDRD246 | NPC26 | 2 |
| iGMDRD451 | Serdemetan | 2 |
| iGMDRD524 | ISX-9 | 3 |
| iGMDRD158 | NSC141540 | 6 |
| iGMDRD255 | SB225002 | 4 |
| iGMDRD105 | Triptolide | 1 |
| iGMDRD782 | DC-45-A2 | 2 |
| iGMDRD226 | ML006 | 2 |
| iGMDRD885 | Compound 110 | 3 |
| iGMDRD870 | BRD63610 | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in GRK4
CLASSFICATION
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