GRK4

Summary: This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating its deactivation. This gene has been linked to both genetic and acquired hypertension. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
NameG protein-coupled receptor kinase 4
OMIM IDMIM:137026
Ensembl IDEnsembl:ENSG00000125388
HGNC IDHGNC:HGNC:4543
PHARMGKB IDPA28941
Map Location4p16.3

GO terms in GRK4


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Term Type
Evidence Type
GO Term ID
GO Des.
BP IEA GO:0002031 G-protein coupled receptor internalization
BP IEA GO:0006468 protein phosphorylation
BP IEA GO:0007165 signal transduction
BP TAS GO:0008277 regulation of G-protein coupled receptor protein signaling pathway
BP TAS GO:0022400 regulation of rhodopsin mediated signaling pathway
BP IDA GO:0031623 receptor internalization
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Gene expression in normal tissue: GRK4

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 64BOWEtissue: BOWE cancer: BOWEL model num: 0BOWELtissue: BOWEL cancer: undefined model num: 16LUNtissue: LUN cancer: LUNG model num: 0LUNGtissue: LUNG cancer: undefined model num: 6

Gene-drug pathway distribution

undefined23p53 pathway1DNA replication1Apoptosis regulation1Purine metabolism1Protein stability and degradation1RTK signaling1Chromatin histone methylation1

Pathways in GRK4


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Database
Pathway ID
Pathway Des.
kegg hsa04062 Chemokine signaling pathway - Homo sapiens (human)
kegg hsa04144 Endocytosis - Homo sapiens (human)
kegg hsa05032 Morphine addiction - Homo sapiens (human)
wikipathways WP289 Myometrial Relaxation and Contraction Pathways
wikipathways WP3929 Chemokine signaling pathway
wikipathways WP536 Calcium Regulation in the Cardiac Cell
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD446 LY 2183240 2
iGMDRD85 Ursolic acid 2
iGMDRD57 Chloropentafluorobenzene 3
iGMDRD314 Tanespimycin 5
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in GRK4

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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