MARK1
Summary:
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| microtubule affinity regulating kinase 1 | MIM:606511 | Ensembl:ENSG00000116141 | HGNC:HGNC:6896 | PA30639 | 1q41 |
GO terms in MARK1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IBA | GO:0000226 | microtubule cytoskeleton organization |
| BP | ISS | GO:0000226 | microtubule cytoskeleton organization |
| BP | ISS | GO:0001764 | neuron migration |
| BP | IDA | GO:0006468 | protein phosphorylation |
| BP | IMP | GO:0006468 | protein phosphorylation |
| BP | ISS | GO:0007010 | cytoskeleton organization |
| BP | ISS | GO:0010975 | regulation of neuron projection development |
| BP | IEA | GO:0016055 | Wnt signaling pathway |
| BP | NAS | GO:0018105 | peptidyl-serine phosphorylation |
| BP | IBA | GO:0035556 | intracellular signal transduction |
| BP | IDA | GO:0035556 | intracellular signal transduction |
| BP | ISS | GO:0050773 | regulation of dendrite development |
| BP | ISS | GO:0051654 | establishment of mitochondrion localization |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | ISS | GO:0005737 | cytoplasm |
| CC | ISS | GO:0005856 | cytoskeleton |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | TAS | GO:0015630 | microtubule cytoskeleton |
| CC | IDA | GO:0030425 | dendrite |
| MF | IDA | GO:0000287 | magnesium ion binding |
| MF | IDA | GO:0001786 | phosphatidylserine binding |
| MF | IBA | GO:0004674 | protein serine/threonine kinase activity |
| MF | IDA | GO:0004674 | protein serine/threonine kinase activity |
| MF | NAS | GO:0004674 | protein serine/threonine kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0005524 | ATP binding |
| MF | IDA | GO:0005546 | phosphatidylinositol-4,5-bisphosphate binding |
| MF | IBA | GO:0050321 | tau-protein kinase activity |
| MF | IMP | GO:0050321 | tau-protein kinase activity |
| MF | ISS | GO:0050321 | tau-protein kinase activity |
| MF | IDA | GO:0070300 | phosphatidic acid binding |
Gene expression in normal tissue: MARK1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in MARK1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP2038 | Regulation of Microtubule Cytoskeleton |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD505 | Pevonedistat | 3 |
| iGMDRD269 | Purmorphamine | 2 |
| iGMDRD286 | Nsc 632839 | 2 |
| iGMDRD871 | BRD6368 | 2 |
| iGMDRD231 | Importazole | 1 |
| iGMDRD77 | Itraconazole | 6 |
| iGMDRD154 | NSC23766 | 4 |
| iGMDRD219 | Bax channel blocker | 3 |
| iGMDRD341 | Triacsin c | 3 |
| iGMDRD424 | Tamatinib | 4 |
| iGMDRD560 | MK-2206 | 4 |
| iGMDRD148 | Pifithrin-mu | 3 |
| iGMDRD330 | BRD4132 | 3 |
| iGMDRD307 | Manumycin A | 1 |
| iGMDRD524 | ISX-9 | 6 |
| iGMDRD369 | TGX-115 | 3 |
| iGMDRD577 | BIX01294 | 3 |
| iGMDRD506 | Fedratinib | 1 |
| iGMDRD399 | Selumetinib | 2 |
| iGMDRD887 | Compound 23 citrate | 3 |
| iGMDRD188 | Piperlongumine | 1 |
| iGMDRD870 | BRD63610 | 4 |
| iGMDRD255 | SB225002 | 3 |
| iGMDRD634 | SCHEMBL2608041 | 3 |
| iGMDRD280 | CYTOCHALASIN B | 2 |
| iGMDRD394 | BX-795 | 3 |
| iGMDRD61 | Kinetin riboside | 3 |
| iGMDRD420 | Leucascandrolide A | 5 |
| iGMDRD579 | PF750 | 2 |
| iGMDRD387 | CHIR-99021 | 3 |
| iGMDRD889 | Compound 7d-cis | 3 |
| iGMDRD126 | Tipifarnib | 5 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in MARK1
CLASSFICATION
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