RICTOR


Summary: RICTOR and MTOR (FRAP1; MIM 601231) are components of a protein complex that integrates nutrient- and growth factor-derived signals to regulate cell growth (Sarbassov et al., 2004 [PubMed 15268862]).[supplied by OMIM, Mar 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
RPTOR independent companion of MTOR complex 2MIM:609022Ensembl:ENSG00000164327HGNC:HGNC:28611PA1656604555p13.1

Gene Categories:

CLINICALLY ACTIONABLE

GO terms in RICTOR


Term TypeEvidence TypeGO Term IDGO Des.
BPIEAGO:0001938positive regulation of endothelial cell proliferation
BPISSGO:0009792embryo development ending in birth or egg hatching
BPIEAGO:0010468regulation of gene expression
BPIGIGO:0018105peptidyl-serine phosphorylation
BPIBAGO:0030010establishment of cell polarity
BPIEAGO:0030838positive regulation of actin filament polymerization
BPIBAGO:0030950establishment or maintenance of actin cytoskeleton polarity
BPIBAGO:0031532actin cytoskeleton reorganization
BPIMPGO:0031532actin cytoskeleton reorganization
BPIEAGO:0031929TOR signaling
BPIMPGO:0032008positive regulation of TOR signaling
BPTASGO:0032148activation of protein kinase B activity
BPIBAGO:0032956regulation of actin cytoskeleton organization
BPIMPGO:0032956regulation of actin cytoskeleton organization
BPIEAGO:0033135regulation of peptidyl-serine phosphorylation
BPIBAGO:0042325regulation of phosphorylation
BPIEAGO:0043087regulation of GTPase activity
BPIEAGO:0050727regulation of inflammatory response
BPIEAGO:0050731positive regulation of peptidyl-tyrosine phosphorylation
BPIDAGO:0051896regulation of protein kinase B signaling
BPIBAGO:0051897positive regulation of protein kinase B signaling
BPIEAGO:2000114regulation of establishment of cell polarity
CCTASGO:0005829cytosol
CCIBAGO:0031932TORC2 complex
CCIDAGO:0031932TORC2 complex
MFIPIGO:0005515protein binding
MFIBAGO:0008047enzyme activator activity
MFIPIGO:0019901protein kinase binding
MFIEAGO:0043022ribosome binding

Gene expression in normal tissue: RICTOR

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in RICTOR


DatabasePathway IDPathway Des.
pidcxcr3pathwayCXCR3-mediated signaling events
pidcxcr4_pathwayCXCR4-mediated signaling events
piderbb1_downstream_pathwayErbB1 downstream signaling
pidilk_pathwayIntegrin-linked kinase signaling
pidmtor_4pathwaymTOR signaling pathway
pidpi3kciaktpathwayClass I PI3K signaling events mediated by Akt
kegghsa04150mTOR signaling pathway - Homo sapiens (human)
netpathPathway_EGFR1EGFR1
netpathPathway_GhrelinGhrelin
netpathPathway_Oncostatin_MOncostatin_M
wikipathwaysWP1471Target Of Rapamycin (TOR) Signaling
wikipathwaysWP2263Androgen Receptor Network in Prostate Cancer
wikipathwaysWP2374Oncostatin M Signaling Pathway
wikipathwaysWP3844PI3K-AKT-mTOR signaling pathway and therapeutic opportunities
wikipathwaysWP3888VEGFA-VEGFR2 Signaling Pathway
wikipathwaysWP3915Angiopoietin Like Protein 8 Regulatory Pathway
wikipathwaysWP4011Steatosis AOP
wikipathwaysWP437EGF-EGFR Signaling Pathway
reactomeR-HSA-1257604PIP3 activates AKT signaling
reactomeR-HSA-1280218Adaptive Immune System
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-1643685Disease
reactomeR-HSA-168256Immune System
reactomeR-HSA-194138Signaling by VEGF
reactomeR-HSA-212436Generic Transcription Pathway
reactomeR-HSA-2219528PI3K/AKT Signaling in Cancer
reactomeR-HSA-3700989Transcriptional Regulation by TP53
reactomeR-HSA-388841Costimulation by the CD28 family
reactomeR-HSA-389356CD28 co-stimulation
reactomeR-HSA-389357CD28 dependent PI3K/Akt signaling
reactomeR-HSA-4420097VEGFA-VEGFR2 Pathway
reactomeR-HSA-5218920VEGFR2 mediated vascular permeability
reactomeR-HSA-5633007Regulation of TP53 Activity
reactomeR-HSA-5663202Diseases of signal transduction
reactomeR-HSA-5674400Constitutive Signaling by AKT1 E17K in Cancer
reactomeR-HSA-6804757Regulation of TP53 Degradation
reactomeR-HSA-6806003Regulation of TP53 Expression and Degradation
reactomeR-HSA-73857RNA Polymerase II Transcription
reactomeR-HSA-74160Gene expression (Transcription)
reactomeR-HSA-9006925Intracellular signaling by second messengers
reactomeR-HSA-9006934Signaling by Receptor Tyrosine Kinases

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD151CHM-13
iGMDRD643MLN01281
iGMDRD420Leucascandrolide A3
iGMDRD781Sirolimus3
iGMDRD741Cc-2231
iGMDRD698Neratinib2
iGMDRD280CYTOCHALASIN B5
iGMDRD297Austocystin D3
iGMDRD952mTORC1/2 inhibitor2
iGMDRD631Pandacostat1
iGMDRD187BRD98761
iGMDRD52Rotenone1
iGMDRD318PAC-14
iGMDRD68Paclitaxel1
iGMDRD887Compound 23 citrate2
iGMDRD399Selumetinib3
iGMDRD871BRD63689
iGMDRD414MST-3123
iGMDRD888Compound 443
iGMDRD329Merck602
iGMDRD246NPC262
iGMDRD552AZD-17752
iGMDRD64Parbendazole3
iGMDRD384EHT-18641
iGMDRD268Cerulenin2
iGMDRD42Vorinostat3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in RICTOR

​​​​