RICTOR

Summary: RICTOR and MTOR (FRAP1; MIM 601231) are components of a protein complex that integrates nutrient- and growth factor-derived signals to regulate cell growth (Sarbassov et al., 2004 [PubMed 15268862]).[supplied by OMIM, Mar 2008].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
NameRPTOR independent companion of MTOR complex 2
OMIM IDMIM:609022
Ensembl IDEnsembl:ENSG00000164327
HGNC IDHGNC:HGNC:28611
PHARMGKB IDPA165660455
Map Location5p13.1

Gene Categories:

CLINICALLY ACTIONABLE

GO terms in RICTOR


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Term Type
Evidence Type
GO Term ID
GO Des.
BP IEA GO:0001938 positive regulation of endothelial cell proliferation
BP ISS GO:0009792 embryo development ending in birth or egg hatching
BP IEA GO:0010468 regulation of gene expression
BP IGI GO:0018105 peptidyl-serine phosphorylation
BP IBA GO:0030010 establishment of cell polarity
BP IEA GO:0030838 positive regulation of actin filament polymerization
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Gene expression in normal tissue: RICTOR

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

undefined19Cytoskeleton1Chromatin histone acetylation1ERK MAPK signaling1Apoptosis regulation1Longevity regulating pathway1Biosynthesis of secondary metabolites1Metabolic pathways1

Pathways in RICTOR


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Database
Pathway ID
Pathway Des.
pid cxcr3pathway CXCR3-mediated signaling events
pid cxcr4_pathway CXCR4-mediated signaling events
pid erbb1_downstream_pathway ErbB1 downstream signaling
pid ilk_pathway Integrin-linked kinase signaling
pid mtor_4pathway mTOR signaling pathway
pid pi3kciaktpathway Class I PI3K signaling events mediated by Akt
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD151 CHM-1 3
iGMDRD643 MLN0128 1
iGMDRD420 Leucascandrolide A 3
iGMDRD781 Sirolimus 3
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in RICTOR

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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