STK10
Summary: This gene encodes a member of the Ste20 family of serine/threonine protein kinases, and is similar to several known polo-like kinase kinases. The protein can associate with and phosphorylate polo-like kinase 1, and overexpression of a kinase-dead version of the protein interferes with normal cell cycle progression. The kinase can also negatively regulate interleukin 2 expression in T-cells via the mitogen activated protein kinase kinase 1 pathway. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| serine/threonine kinase 10 | MIM:603919 | Ensembl:ENSG00000072786 | HGNC:HGNC:11388 | PA36197 | 5q35.1 |
GO terms in STK10
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | TAS | GO:0006468 | protein phosphorylation |
| BP | IEA | GO:0007049 | cell cycle |
| BP | IBA | GO:0007346 | regulation of mitotic cell cycle |
| BP | IBA | GO:0023014 | signal transduction by protein phosphorylation |
| BP | IBA | GO:0032147 | activation of protein kinase activity |
| BP | TAS | GO:0043312 | neutrophil degranulation |
| BP | IDA | GO:0046777 | protein autophosphorylation |
| BP | IEA | GO:0071593 | lymphocyte aggregation |
| BP | IBA | GO:2000401 | regulation of lymphocyte migration |
| BP | IMP | GO:2000401 | regulation of lymphocyte migration |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | TAS | GO:0035579 | specific granule membrane |
| CC | HDA | GO:0070062 | extracellular exosome |
| MF | IBA | GO:0004674 | protein serine/threonine kinase activity |
| MF | IDA | GO:0004674 | protein serine/threonine kinase activity |
| MF | TAS | GO:0004674 | protein serine/threonine kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IPI | GO:0042802 | identical protein binding |
| MF | IDA | GO:0042803 | protein homodimerization activity |
Gene expression in normal tissue: STK10
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in STK10
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa04914 | Progesterone-mediated oocyte maturation - Homo sapiens (human) |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-6798695 | Neutrophil degranulation |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD662 | JQ-1 | 3 |
| iGMDRD506 | Fedratinib | 3 |
| iGMDRD64 | Parbendazole | 1 |
| iGMDRD246 | NPC26 | 3 |
| iGMDRD552 | AZD-1775 | 1 |
| iGMDRD451 | Serdemetan | 3 |
| iGMDRD260 | FQI-2 | 3 |
| iGMDRD5 | Tyrphostin AG 1478 | 1 |
| iGMDRD171 | Pemetrexed | 1 |
| iGMDRD705 | Nakiterpiosin | 4 |
| iGMDRD187 | BRD9876 | 3 |
| iGMDRD85 | Ursolic acid | 2 |
| iGMDRD446 | LY 2183240 | 1 |
| iGMDRD193 | Fqi1 | 3 |
| iGMDRD314 | Tanespimycin | 1 |
| iGMDRD123 | Isoevodiamine | 4 |
| iGMDRD151 | CHM-1 | 4 |
| iGMDRD420 | Leucascandrolide A | 3 |
| iGMDRD670 | ML 210 | 3 |
| iGMDRD779 | PRL-3 Inhibitor I | 3 |
| iGMDRD494 | Neopeltolide | 7 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in STK10
CLASSFICATION
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