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STK10

Summary: This gene encodes a member of the Ste20 family of serine/threonine protein kinases, and is similar to several known polo-like kinase kinases. The protein can associate with and phosphorylate polo-like kinase 1, and overexpression of a kinase-dead version of the protein interferes with normal cell cycle progression. The kinase can also negatively regulate interleukin 2 expression in T-cells via the mitogen activated protein kinase kinase 1 pathway. [provided by RefSeq, Jul 2008].

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Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
Nameserine/threonine kinase 10 OMIM IDMIM:603919 Ensembl IDEnsembl:ENSG00000072786 HGNC IDHGNC:HGNC:11388 PHARMGKB IDPA36197 Map Location5q35.1

Gene Categories:

KINASE SERINE THREONINE KINASE TUMOR SUPPRESSOR DRUGGABLE GENOME

GO terms in STK10

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Term Type	Evidence Type	GO Term ID	GO Des.
BP	TAS	GO:0006468	protein phosphorylation
BP	IEA	GO:0007049	cell cycle
BP	IBA	GO:0007346	regulation of mitotic cell cycle
BP	IBA	GO:0023014	signal transduction by protein phosphorylation
BP	IBA	GO:0032147	activation of protein kinase activity
BP	TAS	GO:0043312	neutrophil degranulation

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Gene expression in normal tissue: STK10

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in STK10

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Database	Pathway ID	Pathway Des.
kegg	hsa04914	Progesterone-mediated oocyte maturation - Homo sapiens (human)
reactome	R-HSA-168249	Innate Immune System
reactome	R-HSA-168256	Immune System
reactome	R-HSA-6798695	Neutrophil degranulation

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Gene-Drug: Aster Plot

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Drug ID	Drug Name	Model Num.
iGMDRD662	JQ-1	3
iGMDRD506	Fedratinib	3
iGMDRD64	Parbendazole	1
iGMDRD246	NPC26	3

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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in STK10

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	Model	Level	Reference ID	Tissue	Cancer	Drug	Clinical Response	Source
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