RHPN2
Summary: This gene encodes a member of the rhophilin family of Ras-homologous (Rho)-GTPase binding proteins. The encoded protein binds both GTP- and GDP-bound RhoA and GTP-bound RhoB and may be involved in the organization of the actin cytoskeleton. [provided by RefSeq, Apr 2009].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| rhophilin Rho GTPase binding protein 2 | MIM:617932 | Ensembl:ENSG00000131941 | HGNC:HGNC:19974 | PA134979284 | 19q13.11 |
GO terms in RHPN2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | TAS | GO:0005829 | cytosol |
| CC | IEA | GO:0048471 | perinuclear region of cytoplasm |
| BP | IEA | GO:0007165 | signal transduction |
Gene expression in normal tissue: RHPN2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in RHPN2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-194315 | Signaling by Rho GTPases |
| reactome | R-HSA-194315 | Signaling by Rho GTPases |
| reactome | R-HSA-195258 | RHO GTPase Effectors |
| reactome | R-HSA-195258 | RHO GTPase Effectors |
| reactome | R-HSA-5666185 | RHO GTPases Activate Rhotekin and Rhophilins |
| reactome | R-HSA-5666185 | RHO GTPases Activate Rhotekin and Rhophilins |
| wikipathways | WP524 | G13 Signaling Pathway |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD246 | NPC26 | 3 |
| iGMDRD505 | Pevonedistat | 1 |
| iGMDRD82 | Quiflapon | 3 |
| iGMDRD872 | BRD7137 | 3 |
| iGMDRD414 | MST-312 | 3 |
| iGMDRD871 | BRD6368 | 5 |
| iGMDRD286 | Nsc 632839 | 2 |
| iGMDRD329 | Merck60 | 5 |
| iGMDRD6 | AM-580 | 3 |
| iGMDRD267 | Oligomycin A | 1 |
| iGMDRD77 | Itraconazole | 2 |
| iGMDRD271 | Brefeldin A | 3 |
| iGMDRD137 | Indisulam | 2 |
| iGMDRD202 | Curcumin | 5 |
| iGMDRD158 | NSC141540 | 4 |
| iGMDRD103 | SN-38 | 2 |
| iGMDRD177 | Teniposide | 2 |
| iGMDRD154 | NSC23766 | 2 |
| iGMDRD85 | Ursolic acid | 2 |
| iGMDRD237 | ABT-751 | 2 |
| iGMDRD116 | CD437 | 2 |
| iGMDRD79 | Gemcitabine | 4 |
| iGMDRD701 | NVP-AUY922 | 2 |
| iGMDRD405 | PIK-75 | 3 |
| iGMDRD307 | Manumycin A | 4 |
| iGMDRD330 | BRD4132 | 5 |
| iGMDRD248 | BRD4354 | 5 |
| iGMDRD512 | nutlin 3 | 3 |
| iGMDRD584 | VER 155008 | 2 |
| iGMDRD607 | Ubistatin B | 2 |
| iGMDRD64 | Parbendazole | 3 |
| iGMDRD524 | ISX-9 | 3 |
| iGMDRD23 | Gossypol | 1 |
| iGMDRD356 | PNU-74654 | 2 |
| iGMDRD399 | Selumetinib | 3 |
| iGMDRD730 | Kahalalide F | 1 |
| iGMDRD188 | Piperlongumine | 2 |
| iGMDRD562 | Navitoclax | 4 |
| iGMDRD888 | Compound 44 | 5 |
| iGMDRD577 | BIX01294 | 2 |
| iGMDRD782 | DC-45-A2 | 2 |
| iGMDRD870 | BRD63610 | 2 |
| iGMDRD52 | Rotenone | 5 |
| iGMDRD294 | Batimastat | 3 |
| iGMDRD441 | TW 37 | 2 |
| iGMDRD138 | PX 12 | 2 |
| iGMDRD163 | all trans Retinoic Acid | 2 |
| iGMDRD152 | 179324-69-7 | 2 |
| iGMDRD61 | Kinetin riboside | 4 |
| iGMDRD718 | Pyrvinium pamoate | 3 |
| iGMDRD316 | N9-Isopropyl-olomoucine | 2 |
| iGMDRD427 | ABT737 | 5 |
| iGMDRD494 | Neopeltolide | 5 |
| iGMDRD210 | AC55649 | 1 |
| iGMDRD554 | CHEMBL1434137 | 3 |
| iGMDRD433 | Lexibulin | 1 |
| iGMDRD126 | Tipifarnib | 4 |
| iGMDRD1008 | SR-II-138A | 3 |
| iGMDRD420 | Leucascandrolide A | 2 |
| iGMDRD579 | PF750 | 2 |
| iGMDRD889 | Compound 7d-cis | 2 |
| iGMDRD387 | CHIR-99021 | 1 |
| iGMDRD599 | Salermide | 5 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in RHPN2
CLASSFICATION
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