RIPK2
Summary: This gene encodes a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases. The encoded protein contains a C-terminal caspase activation and recruitment domain (CARD), and is a component of signaling complexes in both the innate and adaptive immune pathways. It is a potent activator of NF-kappaB and inducer of apoptosis in response to various stimuli. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| receptor interacting serine/threonine kinase 2 | MIM:603455 | Ensembl:ENSG00000104312 | HGNC:HGNC:10020 | PA34395 | 8q21.3 |
GO terms in RIPK2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0004674 | protein serine/threonine kinase activity |
| MF | TAS | GO:0004674 | protein serine/threonine kinase activity |
| MF | IBA | GO:0004706 | JUN kinase kinase kinase activity |
| MF | IEA | GO:0004715 | non-membrane spanning protein tyrosine kinase activity |
| MF | IPI | GO:0005102 | signaling receptor binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IPI | GO:0030274 | LIM domain binding |
| MF | IPI | GO:0042802 | identical protein binding |
| MF | IDA | GO:0042803 | protein homodimerization activity |
| MF | IDA | GO:0050700 | CARD domain binding |
| MF | IPI | GO:0050700 | CARD domain binding |
| MF | IPI | GO:0089720 | caspase binding |
| BP | IBA | GO:0000165 | MAPK cascade |
| BP | TAS | GO:0000187 | activation of MAPK activity |
| BP | IEA | GO:0001961 | positive regulation of cytokine-mediated signaling pathway |
| BP | IBA | GO:0002250 | adaptive immune response |
| BP | ISS | GO:0002250 | adaptive immune response |
| BP | IBA | GO:0002819 | regulation of adaptive immune response |
| BP | IEA | GO:0006915 | apoptotic process |
| BP | TAS | GO:0006954 | inflammatory response |
| BP | TAS | GO:0007165 | signal transduction |
| BP | ISS | GO:0007249 | I-kappaB kinase/NF-kappaB signaling |
| BP | TAS | GO:0007254 | JNK cascade |
| BP | IBA | GO:0007257 | activation of JUN kinase activity |
| BP | IDA | GO:0010800 | positive regulation of peptidyl-threonine phosphorylation |
| BP | IDA | GO:0010942 | positive regulation of cell death |
| BP | IEA | GO:0018108 | peptidyl-tyrosine phosphorylation |
| BP | IMP | GO:0031398 | positive regulation of protein ubiquitination |
| BP | NAS | GO:0031398 | positive regulation of protein ubiquitination |
| BP | IEA | GO:0031663 | lipopolysaccharide-mediated signaling pathway |
| BP | IMP | GO:0032092 | positive regulation of protein binding |
| BP | IEA | GO:0032722 | positive regulation of chemokine production |
| BP | NAS | GO:0032727 | positive regulation of interferon-alpha production |
| BP | NAS | GO:0032728 | positive regulation of interferon-beta production |
| BP | IEA | GO:0032729 | positive regulation of interferon-gamma production |
| BP | NAS | GO:0032735 | positive regulation of interleukin-12 production |
| BP | IEA | GO:0032743 | positive regulation of interleukin-2 production |
| BP | IEA | GO:0032755 | positive regulation of interleukin-6 production |
| BP | IEA | GO:0032760 | positive regulation of tumor necrosis factor production |
| BP | IEA | GO:0033091 | positive regulation of immature T cell proliferation |
| BP | IDA | GO:0033138 | positive regulation of peptidyl-serine phosphorylation |
| BP | IDA | GO:0034134 | toll-like receptor 2 signaling pathway |
| BP | IEA | GO:0034142 | toll-like receptor 4 signaling pathway |
| BP | IEA | GO:0042098 | T cell proliferation |
| BP | IBA | GO:0043029 | T cell homeostasis |
| BP | IEA | GO:0043065 | positive regulation of apoptotic process |
| BP | TAS | GO:0043066 | negative regulation of apoptotic process |
| BP | IDA | GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB signaling |
| BP | IEA | GO:0043330 | response to exogenous dsRNA |
| BP | IBA | GO:0045087 | innate immune response |
| BP | IDA | GO:0045087 | innate immune response |
| BP | ISS | GO:0045087 | innate immune response |
| BP | IEA | GO:0045627 | positive regulation of T-helper 1 cell differentiation |
| BP | NAS | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0046330 | positive regulation of JNK cascade |
| BP | IEA | GO:0046641 | positive regulation of alpha-beta T cell proliferation |
| BP | IDA | GO:0050718 | positive regulation of interleukin-1 beta secretion |
| BP | IDA | GO:0050731 | positive regulation of peptidyl-tyrosine phosphorylation |
| BP | IEA | GO:0050830 | defense response to Gram-positive bacterium |
| BP | ISS | GO:0050852 | T cell receptor signaling pathway |
| BP | TAS | GO:0050852 | T cell receptor signaling pathway |
| BP | IBA | GO:0051092 | positive regulation of NF-kappaB transcription factor activity |
| BP | IDA | GO:0051092 | positive regulation of NF-kappaB transcription factor activity |
| BP | IMP | GO:0051092 | positive regulation of NF-kappaB transcription factor activity |
| BP | TAS | GO:0051092 | positive regulation of NF-kappaB transcription factor activity |
| BP | IBA | GO:0070266 | necroptotic process |
| BP | IEA | GO:0070374 | positive regulation of ERK1 and ERK2 cascade |
| BP | TAS | GO:0070423 | nucleotide-binding oligomerization domain containing signaling pathway |
| BP | IEA | GO:0070427 | nucleotide-binding oligomerization domain containing 1 signaling pathway |
| BP | IDA | GO:0070431 | nucleotide-binding oligomerization domain containing 2 signaling pathway |
| BP | TAS | GO:0070498 | interleukin-1-mediated signaling pathway |
| BP | IEA | GO:0070671 | response to interleukin-12 |
| BP | IEA | GO:0070673 | response to interleukin-18 |
| BP | IEA | GO:0071223 | cellular response to lipoteichoic acid |
| BP | IEA | GO:0071224 | cellular response to peptidoglycan |
| BP | IDA | GO:0071225 | cellular response to muramyl dipeptide |
| BP | IDA | GO:0097202 | activation of cysteine-type endopeptidase activity |
| BP | IEA | GO:1904417 | positive regulation of xenophagy |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | IDA | GO:0005856 | cytoskeleton |
| CC | IDA | GO:0031982 | vesicle |
| CC | IDA | GO:0032991 | protein-containing complex |
| CC | IMP | GO:0032991 | protein-containing complex |
Gene expression in normal tissue: RIPK2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in RIPK2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-1280218 | Adaptive Immune System |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade |
| reactome | R-HSA-166058 | MyD88:Mal cascade initiated on plasma membrane |
| reactome | R-HSA-166166 | MyD88-independent TLR4 cascade |
| reactome | R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade |
| reactome | R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade |
| reactome | R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade |
| reactome | R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade |
| reactome | R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade |
| reactome | R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade |
| reactome | R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-168638 | NOD1/2 Signaling Pathway |
| reactome | R-HSA-168638 | NOD1/2 Signaling Pathway |
| reactome | R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways |
| reactome | R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways |
| reactome | R-HSA-168898 | Toll-Like Receptors Cascades |
| reactome | R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade |
| reactome | R-HSA-193639 | p75NTR signals via NF-kB |
| reactome | R-HSA-193704 | p75 NTR receptor-mediated signalling |
| reactome | R-HSA-202403 | TCR signaling |
| reactome | R-HSA-202424 | Downstream TCR signaling |
| reactome | R-HSA-209543 | p75NTR recruits signalling complexes |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-445989 | TAK1 activates NFkB by phosphorylation and activation of IKKs complex |
| reactome | R-HSA-446652 | Interleukin-1 family signaling |
| reactome | R-HSA-448424 | Interleukin-17 signaling |
| reactome | R-HSA-449147 | Signaling by Interleukins |
| reactome | R-HSA-450294 | MAP kinase activation |
| reactome | R-HSA-450302 | activated TAK1 mediates p38 MAPK activation |
| reactome | R-HSA-450321 | JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 |
| reactome | R-HSA-5688426 | Deubiquitination |
| reactome | R-HSA-5689896 | Ovarian tumor domain proteases |
| reactome | R-HSA-597592 | Post-translational protein modification |
| reactome | R-HSA-73887 | Death Receptor Signalling |
| reactome | R-HSA-9020702 | Interleukin-1 signaling |
| reactome | R-HSA-937061 | TRIF(TICAM1)-mediated TLR4 signaling |
| reactome | R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation |
| reactome | R-HSA-975155 | MyD88 dependent cascade initiated on endosome |
| reactome | R-HSA-975871 | MyD88 cascade initiated on plasma membrane |
| biocarta | faspathway | fas signaling pathway (cd95) |
| pid | il12_2pathway | IL12-mediated signaling events |
| pid | nfkappabcanonicalpathway | Canonical NF-kappaB pathway |
| pid | p75ntrpathway | p75(NTR)-mediated signaling |
| netpath | Pathway_TCR | TCR |
| kegg | hsa04621 | NOD-like receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa04722 | Neurotrophin signaling pathway - Homo sapiens (human) |
| kegg | hsa05131 | Shigellosis - Homo sapiens (human) |
| kegg | hsa05152 | Tuberculosis - Homo sapiens (human) |
| wikipathways | WP1433 | Nucleotide-binding Oligomerization Domain (NOD) pathway |
| wikipathways | WP2864 | Apoptosis-related network due to altered Notch3 in ovarian cancer |
| wikipathways | WP314 | Fas Ligand (FasL) pathway and Stress induction of Heat Shock Proteins (HSP) regulation |
| wikipathways | WP69 | T-Cell antigen Receptor (TCR) Signaling Pathway |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD560 | MK-2206 | 6 |
| iGMDRD427 | ABT737 | 3 |
| iGMDRD494 | Neopeltolide | 2 |
| iGMDRD330 | BRD4132 | 6 |
| iGMDRD599 | Salermide | 3 |
| iGMDRD889 | Compound 7d-cis | 1 |
| iGMDRD248 | BRD4354 | 6 |
| iGMDRD420 | Leucascandrolide A | 5 |
| iGMDRD280 | CYTOCHALASIN B | 3 |
| iGMDRD154 | NSC23766 | 3 |
| iGMDRD718 | Pyrvinium pamoate | 3 |
| iGMDRD6 | AM-580 | 3 |
| iGMDRD441 | TW 37 | 6 |
| iGMDRD267 | Oligomycin A | 1 |
| iGMDRD52 | Rotenone | 6 |
| iGMDRD231 | Importazole | 3 |
| iGMDRD271 | Brefeldin A | 3 |
| iGMDRD23 | Gossypol | 6 |
| iGMDRD82 | Quiflapon | 3 |
| iGMDRD524 | ISX-9 | 6 |
| iGMDRD871 | BRD6368 | 6 |
| iGMDRD888 | Compound 44 | 2 |
| iGMDRD577 | BIX01294 | 6 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in RIPK2
CLASSFICATION
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