RIPK2


Summary: This gene encodes a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases. The encoded protein contains a C-terminal caspase activation and recruitment domain (CARD), and is a component of signaling complexes in both the innate and adaptive immune pathways. It is a potent activator of NF-kappaB and inducer of apoptosis in response to various stimuli. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
receptor interacting serine/threonine kinase 2MIM:603455Ensembl:ENSG00000104312HGNC:HGNC:10020PA343958q21.3

GO terms in RIPK2


Term TypeEvidence TypeGO Term IDGO Des.
MFIBAGO:0004674protein serine/threonine kinase activity
MFTASGO:0004674protein serine/threonine kinase activity
MFIBAGO:0004706JUN kinase kinase kinase activity
MFIEAGO:0004715non-membrane spanning protein tyrosine kinase activity
MFIPIGO:0005102signaling receptor binding
MFIPIGO:0005515protein binding
MFIEAGO:0005524ATP binding
MFIPIGO:0030274LIM domain binding
MFIPIGO:0042802identical protein binding
MFIDAGO:0042803protein homodimerization activity
MFIDAGO:0050700CARD domain binding
MFIPIGO:0050700CARD domain binding
MFIPIGO:0089720caspase binding
BPIBAGO:0000165MAPK cascade
BPTASGO:0000187activation of MAPK activity
BPIEAGO:0001961positive regulation of cytokine-mediated signaling pathway
BPIBAGO:0002250adaptive immune response
BPISSGO:0002250adaptive immune response
BPIBAGO:0002819regulation of adaptive immune response
BPIEAGO:0006915apoptotic process
BPTASGO:0006954inflammatory response
BPTASGO:0007165signal transduction
BPISSGO:0007249I-kappaB kinase/NF-kappaB signaling
BPTASGO:0007254JNK cascade
BPIBAGO:0007257activation of JUN kinase activity
BPIDAGO:0010800positive regulation of peptidyl-threonine phosphorylation
BPIDAGO:0010942positive regulation of cell death
BPIEAGO:0018108peptidyl-tyrosine phosphorylation
BPIMPGO:0031398positive regulation of protein ubiquitination
BPNASGO:0031398positive regulation of protein ubiquitination
BPIEAGO:0031663lipopolysaccharide-mediated signaling pathway
BPIMPGO:0032092positive regulation of protein binding
BPIEAGO:0032722positive regulation of chemokine production
BPNASGO:0032727positive regulation of interferon-alpha production
BPNASGO:0032728positive regulation of interferon-beta production
BPIEAGO:0032729positive regulation of interferon-gamma production
BPNASGO:0032735positive regulation of interleukin-12 production
BPIEAGO:0032743positive regulation of interleukin-2 production
BPIEAGO:0032755positive regulation of interleukin-6 production
BPIEAGO:0032760positive regulation of tumor necrosis factor production
BPIEAGO:0033091positive regulation of immature T cell proliferation
BPIDAGO:0033138positive regulation of peptidyl-serine phosphorylation
BPIDAGO:0034134toll-like receptor 2 signaling pathway
BPIEAGO:0034142toll-like receptor 4 signaling pathway
BPIEAGO:0042098T cell proliferation
BPIBAGO:0043029T cell homeostasis
BPIEAGO:0043065positive regulation of apoptotic process
BPTASGO:0043066negative regulation of apoptotic process
BPIDAGO:0043123positive regulation of I-kappaB kinase/NF-kappaB signaling
BPIEAGO:0043330response to exogenous dsRNA
BPIBAGO:0045087innate immune response
BPIDAGO:0045087innate immune response
BPISSGO:0045087innate immune response
BPIEAGO:0045627positive regulation of T-helper 1 cell differentiation
BPNASGO:0045944positive regulation of transcription by RNA polymerase II
BPIEAGO:0046330positive regulation of JNK cascade
BPIEAGO:0046641positive regulation of alpha-beta T cell proliferation
BPIDAGO:0050718positive regulation of interleukin-1 beta secretion
BPIDAGO:0050731positive regulation of peptidyl-tyrosine phosphorylation
BPIEAGO:0050830defense response to Gram-positive bacterium
BPISSGO:0050852T cell receptor signaling pathway
BPTASGO:0050852T cell receptor signaling pathway
BPIBAGO:0051092positive regulation of NF-kappaB transcription factor activity
BPIDAGO:0051092positive regulation of NF-kappaB transcription factor activity
BPIMPGO:0051092positive regulation of NF-kappaB transcription factor activity
BPTASGO:0051092positive regulation of NF-kappaB transcription factor activity
BPIBAGO:0070266necroptotic process
BPIEAGO:0070374positive regulation of ERK1 and ERK2 cascade
BPTASGO:0070423nucleotide-binding oligomerization domain containing signaling pathway
BPIEAGO:0070427nucleotide-binding oligomerization domain containing 1 signaling pathway
BPIDAGO:0070431nucleotide-binding oligomerization domain containing 2 signaling pathway
BPTASGO:0070498interleukin-1-mediated signaling pathway
BPIEAGO:0070671response to interleukin-12
BPIEAGO:0070673response to interleukin-18
BPIEAGO:0071223cellular response to lipoteichoic acid
BPIEAGO:0071224cellular response to peptidoglycan
BPIDAGO:0071225cellular response to muramyl dipeptide
BPIDAGO:0097202activation of cysteine-type endopeptidase activity
BPIEAGO:1904417positive regulation of xenophagy
CCIDAGO:0005737cytoplasm
CCIDAGO:0005829cytosol
CCTASGO:0005829cytosol
CCIDAGO:0005856cytoskeleton
CCIDAGO:0031982vesicle
CCIDAGO:0032991protein-containing complex
CCIMPGO:0032991protein-containing complex

Gene expression in normal tissue: RIPK2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in RIPK2


DatabasePathway IDPathway Des.
reactomeR-HSA-1280215Cytokine Signaling in Immune system
reactomeR-HSA-1280218Adaptive Immune System
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-166016Toll Like Receptor 4 (TLR4) Cascade
reactomeR-HSA-166058MyD88:Mal cascade initiated on plasma membrane
reactomeR-HSA-166166MyD88-independent TLR4 cascade
reactomeR-HSA-168138Toll Like Receptor 9 (TLR9) Cascade
reactomeR-HSA-168142Toll Like Receptor 10 (TLR10) Cascade
reactomeR-HSA-168164Toll Like Receptor 3 (TLR3) Cascade
reactomeR-HSA-168176Toll Like Receptor 5 (TLR5) Cascade
reactomeR-HSA-168179Toll Like Receptor TLR1:TLR2 Cascade
reactomeR-HSA-168181Toll Like Receptor 7/8 (TLR7/8) Cascade
reactomeR-HSA-168188Toll Like Receptor TLR6:TLR2 Cascade
reactomeR-HSA-168249Innate Immune System
reactomeR-HSA-168249Innate Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-168638NOD1/2 Signaling Pathway
reactomeR-HSA-168638NOD1/2 Signaling Pathway
reactomeR-HSA-168643Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
reactomeR-HSA-168643Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
reactomeR-HSA-168898Toll-Like Receptors Cascades
reactomeR-HSA-181438Toll Like Receptor 2 (TLR2) Cascade
reactomeR-HSA-193639p75NTR signals via NF-kB
reactomeR-HSA-193704p75 NTR receptor-mediated signalling
reactomeR-HSA-202403TCR signaling
reactomeR-HSA-202424Downstream TCR signaling
reactomeR-HSA-209543p75NTR recruits signalling complexes
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-445989TAK1 activates NFkB by phosphorylation and activation of IKKs complex
reactomeR-HSA-446652Interleukin-1 family signaling
reactomeR-HSA-448424Interleukin-17 signaling
reactomeR-HSA-449147Signaling by Interleukins
reactomeR-HSA-450294MAP kinase activation
reactomeR-HSA-450302activated TAK1 mediates p38 MAPK activation
reactomeR-HSA-450321JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
reactomeR-HSA-5688426Deubiquitination
reactomeR-HSA-5689896Ovarian tumor domain proteases
reactomeR-HSA-597592Post-translational protein modification
reactomeR-HSA-73887Death Receptor Signalling
reactomeR-HSA-9020702Interleukin-1 signaling
reactomeR-HSA-937061TRIF(TICAM1)-mediated TLR4 signaling
reactomeR-HSA-975138TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
reactomeR-HSA-975155MyD88 dependent cascade initiated on endosome
reactomeR-HSA-975871MyD88 cascade initiated on plasma membrane
biocartafaspathwayfas signaling pathway (cd95)
pidil12_2pathwayIL12-mediated signaling events
pidnfkappabcanonicalpathwayCanonical NF-kappaB pathway
pidp75ntrpathwayp75(NTR)-mediated signaling
netpathPathway_TCRTCR
kegghsa04621NOD-like receptor signaling pathway - Homo sapiens (human)
kegghsa04722Neurotrophin signaling pathway - Homo sapiens (human)
kegghsa05131Shigellosis - Homo sapiens (human)
kegghsa05152Tuberculosis - Homo sapiens (human)
wikipathwaysWP1433Nucleotide-binding Oligomerization Domain (NOD) pathway
wikipathwaysWP2864Apoptosis-related network due to altered Notch3 in ovarian cancer
wikipathwaysWP314Fas Ligand (FasL) pathway and Stress induction of Heat Shock Proteins (HSP) regulation
wikipathwaysWP69T-Cell antigen Receptor (TCR) Signaling Pathway

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD560MK-22066
iGMDRD427ABT7373
iGMDRD494Neopeltolide2
iGMDRD330BRD41326
iGMDRD599Salermide3
iGMDRD889Compound 7d-cis1
iGMDRD248BRD43546
iGMDRD420Leucascandrolide A5
iGMDRD280CYTOCHALASIN B3
iGMDRD154NSC237663
iGMDRD718Pyrvinium pamoate3
iGMDRD6AM-5803
iGMDRD441TW 376
iGMDRD267Oligomycin A1
iGMDRD52Rotenone6
iGMDRD231Importazole3
iGMDRD271Brefeldin A3
iGMDRD23Gossypol6
iGMDRD82Quiflapon3
iGMDRD524ISX-96
iGMDRD871BRD63686
iGMDRD888Compound 442
iGMDRD577BIX012946

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in RIPK2

​​​​