MAP4K2
Summary: The protein encoded by this gene is a member of the serine/threonine protein kinase family. Although this kinase is found in many tissues, its expression in lymphoid follicles is restricted to the cells of germinal centre, where it may participate in B-cell differentiation. This kinase can be activated by TNF-alpha, and has been shown to specifically activate MAP kinases. This kinase is also found to interact with TNF receptor-associated factor 2 (TRAF2), which is involved in the activation of MAP3K1/MEKK1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| mitogen-activated protein kinase kinase kinase kinase 2 | MIM:603166 | Ensembl:ENSG00000168067 | HGNC:HGNC:6864 | PA30610 | 11q13.1 |
GO terms in MAP4K2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0004674 | protein serine/threonine kinase activity |
| MF | IDA | GO:0004674 | protein serine/threonine kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0005524 | ATP binding |
| MF | IBA | GO:0008349 | MAP kinase kinase kinase kinase activity |
| MF | IPI | GO:0031435 | mitogen-activated protein kinase kinase kinase binding |
| BP | IBA | GO:0000165 | MAPK cascade |
| BP | IEA | GO:0000185 | activation of MAPKKK activity |
| BP | IDA | GO:0006468 | protein phosphorylation |
| BP | IEA | GO:0006903 | vesicle targeting |
| BP | TAS | GO:0006955 | immune response |
| BP | TAS | GO:0007254 | JNK cascade |
| BP | IDA | GO:0007257 | activation of JUN kinase activity |
| BP | IBA | GO:0007346 | regulation of mitotic cell cycle |
| BP | IBA | GO:0023014 | signal transduction by protein phosphorylation |
| BP | IBA | GO:0032147 | activation of protein kinase activity |
| BP | IDA | GO:0035556 | intracellular signal transduction |
| BP | IEA | GO:0045087 | innate immune response |
| BP | IDA | GO:0046330 | positive regulation of JNK cascade |
| CC | IEA | GO:0000139 | Golgi membrane |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IEA | GO:0016323 | basolateral plasma membrane |
Gene expression in normal tissue: MAP4K2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in MAP4K2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP231 | TNF alpha Signaling Pathway |
| wikipathways | WP382 | MAPK Signaling Pathway |
| wikipathways | WP3915 | Angiopoietin Like Protein 8 Regulatory Pathway |
| wikipathways | WP481 | Insulin Signaling |
| pid | tnfpathway | TNF receptor signaling pathway |
| netpath | Pathway_TNFalpha | TNFalpha |
| kegg | hsa04010 | MAPK signaling pathway - Homo sapiens (human) |
| biocarta | malpathway | role of mal in rho-mediated activation of srf |
| biocarta | stresspathway | tnf/stress related signaling |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD945 | ML214 | 10 |
| iGMDRD435 | BI-2536 | 6 |
| iGMDRD883 | CIL55A | 6 |
| iGMDRD123 | Isoevodiamine | 4 |
| iGMDRD698 | Neratinib | 3 |
| iGMDRD237 | ABT-751 | 1 |
| iGMDRD84 | Lovastatin acid | 3 |
| iGMDRD486 | Tosedostat | 6 |
| iGMDRD82 | Quiflapon | 1 |
| iGMDRD300 | Tozasertib | 10 |
| iGMDRD886 | Compound 1541A | 9 |
| iGMDRD246 | NPC26 | 6 |
| iGMDRD329 | Merck60 | 2 |
| iGMDRD366 | PI-103 | 6 |
| iGMDRD67 | PENFLURIDOL | 3 |
| iGMDRD871 | BRD6368 | 12 |
| iGMDRD286 | Nsc 632839 | 6 |
| iGMDRD872 | BRD7137 | 6 |
| iGMDRD267 | Oligomycin A | 3 |
| iGMDRD289 | Parthenolide | 4 |
| iGMDRD6 | AM-580 | 9 |
| iGMDRD105 | Triptolide | 4 |
| iGMDRD705 | Nakiterpiosin | 6 |
| iGMDRD434 | BMS-536924 | 5 |
| iGMDRD251 | ML162 | 6 |
| iGMDRD137 | Indisulam | 3 |
| iGMDRD297 | Austocystin D | 3 |
| iGMDRD280 | CYTOCHALASIN B | 2 |
| iGMDRD679 | Bistramide A | 2 |
| iGMDRD639 | YK 4-279 | 3 |
| iGMDRD316 | N9-Isopropyl-olomoucine | 3 |
| iGMDRD61 | Kinetin riboside | 8 |
| iGMDRD193 | Fqi1 | 6 |
| iGMDRD446 | LY 2183240 | 7 |
| iGMDRD107 | Valdecoxib | 3 |
| iGMDRD781 | Sirolimus | 9 |
| iGMDRD144 | NSC95397 | 9 |
| iGMDRD599 | Salermide | 2 |
| iGMDRD420 | Leucascandrolide A | 3 |
| iGMDRD772 | BRD4770 | 3 |
| iGMDRD126 | Tipifarnib | 5 |
| iGMDRD210 | AC55649 | 1 |
| iGMDRD151 | CHM-1 | 2 |
| iGMDRD524 | ISX-9 | 2 |
| iGMDRD60 | Quinoclamine | 6 |
| iGMDRD64 | Parbendazole | 6 |
| iGMDRD577 | BIX01294 | 7 |
| iGMDRD506 | Fedratinib | 12 |
| iGMDRD562 | Navitoclax | 6 |
| iGMDRD780 | PP-30 | 1 |
| iGMDRD188 | Piperlongumine | 9 |
| iGMDRD441 | TW 37 | 6 |
| iGMDRD885 | Compound 110 | 3 |
| iGMDRD318 | PAC-1 | 11 |
| iGMDRD260 | FQI-2 | 3 |
| iGMDRD255 | SB225002 | 6 |
| iGMDRD138 | PX 12 | 6 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in MAP4K2
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