GUCY1A2
Summary: Soluble guanylate cyclases are heterodimeric proteins that catalyze the conversion of GTP to 3',5'-cyclic GMP and pyrophosphate. The protein encoded by this gene is an alpha subunit of this complex and it interacts with a beta subunit to form the guanylate cyclase enzyme, which is activated by nitric oxide. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:601244 Ensembl IDEnsembl:ENSG00000152402 HGNC IDHGNC:HGNC:4684 PHARMGKB IDPA186 Map Location11q22.3 | |||||
Gene Categories:
DRUGGABLE GENOMEGO terms in GUCY1A2
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Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | TAS | GO:0007165 | signal transduction |
| BP | IEA | GO:0035556 | intracellular signal transduction |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005525 | GTP binding |
| MF | IEA | GO:0020037 | heme binding |
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Gene expression in normal tissue: GUCY1A2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in GUCY1A2
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Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-109582 | Hemostasis |
| reactome | R-HSA-392154 | Nitric oxide stimulates guanylate cyclase |
| reactome | R-HSA-418346 | Platelet homeostasis |
| biocarta | no1pathway | actions of nitric oxide in the heart |
| biocarta | raccpathway | ion channels and their functional role in vascular endothelium |
| kegg | hsa00230 | Purine metabolism - Homo sapiens (human) |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in GUCY1A2
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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