GUCY1A2


Summary: Soluble guanylate cyclases are heterodimeric proteins that catalyze the conversion of GTP to 3',5'-cyclic GMP and pyrophosphate. The protein encoded by this gene is an alpha subunit of this complex and it interacts with a beta subunit to form the guanylate cyclase enzyme, which is activated by nitric oxide. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
guanylate cyclase 1 soluble subunit alpha 2MIM:601244Ensembl:ENSG00000152402HGNC:HGNC:4684PA18611q22.3

Gene Categories:

DRUGGABLE GENOME

GO terms in GUCY1A2


Term TypeEvidence TypeGO Term IDGO Des.
BPTASGO:0007165signal transduction
BPIEAGO:0035556intracellular signal transduction
MFIPIGO:0005515protein binding
MFIEAGO:0005525GTP binding
MFIEAGO:0020037heme binding

Gene expression in normal tissue: GUCY1A2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in GUCY1A2


DatabasePathway IDPathway Des.
reactomeR-HSA-109582Hemostasis
reactomeR-HSA-392154Nitric oxide stimulates guanylate cyclase
reactomeR-HSA-418346Platelet homeostasis
biocartano1pathwayactions of nitric oxide in the heart
biocartaraccpathwayion channels and their functional role in vascular endothelium
kegghsa00230Purine metabolism - Homo sapiens (human)
kegghsa04022cGMP-PKG signaling pathway - Homo sapiens (human)
kegghsa04270Vascular smooth muscle contraction - Homo sapiens (human)
kegghsa04540Gap junction - Homo sapiens (human)
kegghsa04611Platelet activation - Homo sapiens (human)
kegghsa04713Circadian entrainment - Homo sapiens (human)
kegghsa04730Long-term depression - Homo sapiens (human)
kegghsa04921Oxytocin signaling pathway - Homo sapiens (human)
kegghsa04924Renin secretion - Homo sapiens (human)
kegghsa04970Salivary secretion - Homo sapiens (human)
smpdbSMP00050Purine Metabolism
smpdbSMP00144Adenosine Deaminase Deficiency
smpdbSMP00167Adenylosuccinate Lyase Deficiency
smpdbSMP00168AICA-Ribosiduria
smpdbSMP00203Molybdenum Cofactor Deficiency
smpdbSMP00210Purine Nucleoside Phosphorylase Deficiency
smpdbSMP00220Xanthine Dehydrogenase Deficiency (Xanthinuria)
smpdbSMP00364Lesch-Nyhan Syndrome (LNS)
smpdbSMP00365Gout or Kelley-Seegmiller Syndrome
smpdbSMP00427Azathioprine Action Pathway
smpdbSMP00428Mercaptopurine Action Pathway
smpdbSMP00430Thioguanine Action Pathway
smpdbSMP00512Xanthinuria type I
smpdbSMP00513Xanthinuria type II
smpdbSMP00535Adenine phosphoribosyltransferase deficiency (APRT)
smpdbSMP00536Mitochondrial DNA depletion syndrome
smpdbSMP00537Myoadenylate deaminase deficiency
wikipathwaysWP4008NO-cGMP-PKG mediated Neuroprotection
wikipathwaysWP4222Phosphodiesterases in neuronal function

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD330BRD41323
iGMDRD584VER 1550084
iGMDRD512nutlin 34
iGMDRD560MK-22062
iGMDRD424Tamatinib2
iGMDRD85Ursolic acid1
iGMDRD314Tanespimycin2
iGMDRD219Bax channel blocker3
iGMDRD211(1S,3R)-RSL33
iGMDRD154NSC237661
iGMDRD251ML1623
iGMDRD158NSC1415402
iGMDRD271Brefeldin A3
iGMDRD5Tyrphostin AG 14783
iGMDRD105Triptolide5
iGMDRD705Nakiterpiosin2
iGMDRD434BMS-5369247
iGMDRD871BRD63683
iGMDRD286Nsc 6328392
iGMDRD872BRD71372
iGMDRD300Tozasertib3
iGMDRD886Compound 1541A9
iGMDRD246NPC263
iGMDRD126Tipifarnib7
iGMDRD599Salermide4
iGMDRD889Compound 7d-cis2
iGMDRD420Leucascandrolide A3
iGMDRD546BMS-7548073
iGMDRD144NSC953975
iGMDRD670ML 2103
iGMDRD494Neopeltolide1
iGMDRD781Sirolimus1
iGMDRD484Pluripotin3
iGMDRD316N9-Isopropyl-olomoucine1
iGMDRD61Kinetin riboside2
iGMDRD152179324-69-74
iGMDRD679Bistramide A1
iGMDRD634SCHEMBL26080412
iGMDRD171Pemetrexed2
iGMDRD782DC-45-A21
iGMDRD187BRD98764
iGMDRD52Rotenone6
iGMDRD870BRD636107
iGMDRD188Piperlongumine9
iGMDRD100Zebularine2
iGMDRD399Selumetinib1
iGMDRD887Compound 23 citrate7
iGMDRD506Fedratinib4
iGMDRD562Navitoclax1
iGMDRD369TGX-1151
iGMDRD60Quinoclamine6
iGMDRD268Cerulenin1
iGMDRD23Gossypol4

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in GUCY1A2

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