GUCY1A2
Summary: Soluble guanylate cyclases are heterodimeric proteins that catalyze the conversion of GTP to 3',5'-cyclic GMP and pyrophosphate. The protein encoded by this gene is an alpha subunit of this complex and it interacts with a beta subunit to form the guanylate cyclase enzyme, which is activated by nitric oxide. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| guanylate cyclase 1 soluble subunit alpha 2 | MIM:601244 | Ensembl:ENSG00000152402 | HGNC:HGNC:4684 | PA186 | 11q22.3 |
Gene Categories:
DRUGGABLE GENOMEGO terms in GUCY1A2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | TAS | GO:0007165 | signal transduction |
| BP | IEA | GO:0035556 | intracellular signal transduction |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005525 | GTP binding |
| MF | IEA | GO:0020037 | heme binding |
Gene expression in normal tissue: GUCY1A2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in GUCY1A2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-109582 | Hemostasis |
| reactome | R-HSA-392154 | Nitric oxide stimulates guanylate cyclase |
| reactome | R-HSA-418346 | Platelet homeostasis |
| biocarta | no1pathway | actions of nitric oxide in the heart |
| biocarta | raccpathway | ion channels and their functional role in vascular endothelium |
| kegg | hsa00230 | Purine metabolism - Homo sapiens (human) |
| kegg | hsa04022 | cGMP-PKG signaling pathway - Homo sapiens (human) |
| kegg | hsa04270 | Vascular smooth muscle contraction - Homo sapiens (human) |
| kegg | hsa04540 | Gap junction - Homo sapiens (human) |
| kegg | hsa04611 | Platelet activation - Homo sapiens (human) |
| kegg | hsa04713 | Circadian entrainment - Homo sapiens (human) |
| kegg | hsa04730 | Long-term depression - Homo sapiens (human) |
| kegg | hsa04921 | Oxytocin signaling pathway - Homo sapiens (human) |
| kegg | hsa04924 | Renin secretion - Homo sapiens (human) |
| kegg | hsa04970 | Salivary secretion - Homo sapiens (human) |
| smpdb | SMP00050 | Purine Metabolism |
| smpdb | SMP00144 | Adenosine Deaminase Deficiency |
| smpdb | SMP00167 | Adenylosuccinate Lyase Deficiency |
| smpdb | SMP00168 | AICA-Ribosiduria |
| smpdb | SMP00203 | Molybdenum Cofactor Deficiency |
| smpdb | SMP00210 | Purine Nucleoside Phosphorylase Deficiency |
| smpdb | SMP00220 | Xanthine Dehydrogenase Deficiency (Xanthinuria) |
| smpdb | SMP00364 | Lesch-Nyhan Syndrome (LNS) |
| smpdb | SMP00365 | Gout or Kelley-Seegmiller Syndrome |
| smpdb | SMP00427 | Azathioprine Action Pathway |
| smpdb | SMP00428 | Mercaptopurine Action Pathway |
| smpdb | SMP00430 | Thioguanine Action Pathway |
| smpdb | SMP00512 | Xanthinuria type I |
| smpdb | SMP00513 | Xanthinuria type II |
| smpdb | SMP00535 | Adenine phosphoribosyltransferase deficiency (APRT) |
| smpdb | SMP00536 | Mitochondrial DNA depletion syndrome |
| smpdb | SMP00537 | Myoadenylate deaminase deficiency |
| wikipathways | WP4008 | NO-cGMP-PKG mediated Neuroprotection |
| wikipathways | WP4222 | Phosphodiesterases in neuronal function |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD330 | BRD4132 | 3 |
| iGMDRD584 | VER 155008 | 4 |
| iGMDRD512 | nutlin 3 | 4 |
| iGMDRD560 | MK-2206 | 2 |
| iGMDRD424 | Tamatinib | 2 |
| iGMDRD85 | Ursolic acid | 1 |
| iGMDRD314 | Tanespimycin | 2 |
| iGMDRD219 | Bax channel blocker | 3 |
| iGMDRD211 | (1S,3R)-RSL3 | 3 |
| iGMDRD154 | NSC23766 | 1 |
| iGMDRD251 | ML162 | 3 |
| iGMDRD158 | NSC141540 | 2 |
| iGMDRD271 | Brefeldin A | 3 |
| iGMDRD5 | Tyrphostin AG 1478 | 3 |
| iGMDRD105 | Triptolide | 5 |
| iGMDRD705 | Nakiterpiosin | 2 |
| iGMDRD434 | BMS-536924 | 7 |
| iGMDRD871 | BRD6368 | 3 |
| iGMDRD286 | Nsc 632839 | 2 |
| iGMDRD872 | BRD7137 | 2 |
| iGMDRD300 | Tozasertib | 3 |
| iGMDRD886 | Compound 1541A | 9 |
| iGMDRD246 | NPC26 | 3 |
| iGMDRD126 | Tipifarnib | 7 |
| iGMDRD599 | Salermide | 4 |
| iGMDRD889 | Compound 7d-cis | 2 |
| iGMDRD420 | Leucascandrolide A | 3 |
| iGMDRD546 | BMS-754807 | 3 |
| iGMDRD144 | NSC95397 | 5 |
| iGMDRD670 | ML 210 | 3 |
| iGMDRD494 | Neopeltolide | 1 |
| iGMDRD781 | Sirolimus | 1 |
| iGMDRD484 | Pluripotin | 3 |
| iGMDRD316 | N9-Isopropyl-olomoucine | 1 |
| iGMDRD61 | Kinetin riboside | 2 |
| iGMDRD152 | 179324-69-7 | 4 |
| iGMDRD679 | Bistramide A | 1 |
| iGMDRD634 | SCHEMBL2608041 | 2 |
| iGMDRD171 | Pemetrexed | 2 |
| iGMDRD782 | DC-45-A2 | 1 |
| iGMDRD187 | BRD9876 | 4 |
| iGMDRD52 | Rotenone | 6 |
| iGMDRD870 | BRD63610 | 7 |
| iGMDRD188 | Piperlongumine | 9 |
| iGMDRD100 | Zebularine | 2 |
| iGMDRD399 | Selumetinib | 1 |
| iGMDRD887 | Compound 23 citrate | 7 |
| iGMDRD506 | Fedratinib | 4 |
| iGMDRD562 | Navitoclax | 1 |
| iGMDRD369 | TGX-115 | 1 |
| iGMDRD60 | Quinoclamine | 6 |
| iGMDRD268 | Cerulenin | 1 |
| iGMDRD23 | Gossypol | 4 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in GUCY1A2
CLASSFICATION
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