ING1
Summary: This gene encodes a tumor suppressor protein that can induce cell growth arrest and apoptosis. The encoded protein is a nuclear protein that physically interacts with the tumor suppressor protein TP53 and is a component of the p53 signaling pathway. Reduced expression and rearrangement of this gene have been detected in various cancers. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:601566 Ensembl IDEnsembl:ENSG00000153487 HGNC IDHGNC:HGNC:6062 PHARMGKB IDPA29872 Map Location13q34 | |||||
GO terms in ING1
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Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0035064 | methylated histone binding |
| MF | IEA | GO:0046872 | metal ion binding |
| CC | NAS | GO:0005634 | nucleus |
| BP | IEA | GO:0007049 | cell cycle |
| BP | IEA | GO:0008285 | negative regulation of cell proliferation |
Gene expression in normal tissue: ING1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ING1
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Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP615 | Senescence and Autophagy in Cancer |
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Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ING1
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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