ING1
Summary: This gene encodes a tumor suppressor protein that can induce cell growth arrest and apoptosis. The encoded protein is a nuclear protein that physically interacts with the tumor suppressor protein TP53 and is a component of the p53 signaling pathway. Reduced expression and rearrangement of this gene have been detected in various cancers. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| inhibitor of growth family member 1 | MIM:601566 | Ensembl:ENSG00000153487 | HGNC:HGNC:6062 | PA29872 | 13q34 |
GO terms in ING1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0035064 | methylated histone binding |
| MF | IEA | GO:0046872 | metal ion binding |
| CC | NAS | GO:0005634 | nucleus |
| BP | IEA | GO:0007049 | cell cycle |
| BP | IEA | GO:0008285 | negative regulation of cell proliferation |
| BP | IEA | GO:0010941 | regulation of cell death |
| BP | NAS | GO:0030308 | negative regulation of cell growth |
Gene expression in normal tissue: ING1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD42 | Vorinostat | 6 |
| iGMDRD60 | Quinoclamine | 2 |
| iGMDRD886 | Compound 1541A | 2 |
| iGMDRD329 | Merck60 | 6 |
| iGMDRD367 | Ro 28-1675 | 2 |
| iGMDRD231 | Importazole | 3 |
| iGMDRD77 | Itraconazole | 2 |
| iGMDRD318 | PAC-1 | 3 |
| iGMDRD226 | ML006 | 2 |
| iGMDRD634 | SCHEMBL2608041 | 4 |
| iGMDRD123 | Isoevodiamine | 3 |
| iGMDRD466 | Chaetocin | 2 |
| iGMDRD57 | Chloropentafluorobenzene | 2 |
| iGMDRD85 | Ursolic acid | 2 |
| iGMDRD71 | Sparfosic acid | 3 |
| iGMDRD427 | ABT737 | 3 |
| iGMDRD116 | CD437 | 3 |
| iGMDRD560 | MK-2206 | 4 |
| iGMDRD420 | Leucascandrolide A | 1 |
| iGMDRD512 | nutlin 3 | 1 |
| iGMDRD229 | B02 | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ING1
CLASSFICATION
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.